A5048782992- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Sarcoma Diagnosis and Treatment
- Renal cell carcinoma treatment
- Genetic factors in colorectal cancer
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Ovarian cancer diagnosis and treatment
- Urologic and reproductive health conditions
- Cancer, Lipids, and Metabolism
- Cancer Genomics and Diagnostics
- AI in cancer detection
- COVID-19 and healthcare impacts
- Endometrial and Cervical Cancer Treatments
- Ear and Head Tumors
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Colorectal Cancer Treatments and Studies
- Chromatin Remodeling and Cancer
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac tumors and thrombi
- Multiple and Secondary Primary Cancers
- Urological Disorders and Treatments
Humanitas University
2020-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2024
IRCCS Humanitas Research Hospital
2021-2024
University of Naples Federico II
2017-2020
337 Background: The increasing focus on patient-centered care and the development of precision medicine emphasize need for alternative screening pathways high-risk individuals. Family history is a significant risk factor prostate cancer (PCa), identifying patients with genetic predisposition crucial. discovery germline pathogenic variants (PVs) in DNA repair genes (DRGs) underscores importance dedicated approach. This study aimed to evaluate effectiveness compliance tailored protocol that...
803 Background: The primary treatment for non-muscle invasive bladder cancer (NMIBC) is transurethral resection (TUR), often followed by adjuvant intravesical therapies. Given the variable response to therapy, enhancing its efficacy critical reducing recurrence and progression MIBC. Recent studies have shown that MMC induces immunogenic cell death, suggesting potential in effectiveness of other therapies, such as BCG, activating acquired immunity. This study aimed evaluate safety neoadjuvant...
421 Background: Pathogenic variants (PVs) in DNA repair genes (DRG) are linked to a higher risk of aggressive prostate cancer (PCa). Understanding and managing uncertain significance (VUS), however, remains challenge. This study investigates the prevalence germline VUS PCa patients their potential link prognosis following robot-assisted radical prostatectomy (RARP), aiming enhance clinical management stratification. Methods: is part an ongoing screening project Italian population aimed at...
Patients with pT1 high-grade (HG) urothelial carcinoma (UC) and a very high risk of progression might benefit from immediate radical cystectomy (RC), but this option remains controversial. Validation standardized method to evaluate the extent lamina propria (LP) invasion (with recognized prognostic value) in transurethral resection (TURBT) specimens is still needed. The Rete Oncologica Lombarda (ROL) system showed predictive value for after TURBT recent retrospective studies. ROL was...
Epidermal growth factor receptor (EGFR) gene mutations play an important role in the treatment management of non-small cell lung cancer (NSCLC) patients. After a first- or second-generation EGFR tyrosine kinase inhibitor (TKI) therapy, most common resistance mechanism involves selection resistant clone carrying exon 20 p.T790M point mutation. However, also for these patients, treated with third-generation TKI (osimertinib) several mechanisms acquired are described. Here we report case...
Ovarian cancer is considered the leading cause of death among gynecologic neoplasias. Breast metastases from primary ovarian have been reported in only 0.03-0.6% all breast cancers. A 38-year-old female, multipara, affected by advanced and undergone a total abdominal hysterectomy with bilateral salpingo-oophorectomy, omentectomy, pelvic peritonectomy two years earlier, was discovered to metastasis. She underwent quadrantectomy (QSI) an open biopsy nodularity attached pectoral muscle fascia:...
At the end of February, Italian National Health Service reported a hot spot Coronavirus disease in Lombardy region. COVID-19 is highly pathogenic viral infection which poses some challenges for healthcare workers. Indeed, Pathology Departments are involved reorganizing samples' management, from their delivery until processing, according to and WHO guidelines. Since has been declared spot, our Department adopted policy reduce personnel. Also, College American Pathologists (CAP) urged Centers...
Transition to digital pathology usually takes months or years be completed. We were familiarizing ourselves with solutions at the time when COVID-19 outbreak forced us embark on an abrupt transition pathology.
Sinonasal mucosal melanoma is a rare and highly aggressive tumour. This tumour often carries poor prognosis because of local invasion early distant metastasis. It's, in fact, an aggressive, fortunately rare, disease. It's more common among population their seventies, with prolonged course due to innocuous symptoms. We report case sinonasal 56-years old male who presented brownish mass involving right nasal fossa, swelling spontaneous epistaxis. this for the one-time reconstruction treatment...
Solitary fibrous tumor (SFT) is a rare neoplasm of mesenchymal origin. The kidney represents an unusual location for SFT and the diagnosis treatment renal remains challenging. present study reports case right incidentally discovered in 52-year old woman. Radiological findings from computed tomography magnetic resonance imaging were not specific but highly suspect malignant neoplasm. definitive relied on histological examination immunohistochemical staining CD34 signal transducer activator...
Renal medullary carcinoma (RMC) is a rare entity with poor prognosis bearing inactivating genomic alterations in SMARCB1/INI1 resulting the loss of expression INI1 and occurring young patients sickle cell trait or disease. Recently, examples histological characteristics RMC have been described older without hemoglobinopathies provisionally termed "Renal unclassified phenotype" (RCCU-MP). Fluorescence situ Hybridization (FISH) can detect consisting mostly translocation one allele deletion...
Epidermal growth factor receptor ( EGFR ) gene mutations play an important role in the treatment management of non-small cell lung cancer (NSCLC) patients. After a first- or second-generation tyrosine kinase inhibitor (TKI) therapy, most common resistance mechanism involves selection resistant clone carrying exon 20 p.T790M point mutation. However, also for these patients, treated with third-generation TKI (osimertinib) several mechanisms acquired are described. Here we report case...
342 Background: Pathogenic variants (PVs) in DNA repair genes (DRG), such as BRCA1, BRCA2, ATM, CHEK2, etc., have implications for prostate cancer (PCa) family genetic counselling, testing and risk stratification men. However, understanding how to counsel patients with of unknown significance (VUS) is an unmet clinical need. On the other hand, there necessity cautiously interpret VUS findings bolster evaluations additional evidence pathogenicity. In this study, we aim investigate prevalence...
278 Background: Family history is a major prostate cancer (PCa) risk factor. Pathogenic gene variants (e.g., BRCA1/BRCA2) greatly increase PCa (2.5 to 8.6-fold for <65-year-olds) and affect outcomes. This study assesses an enhanced screening protocol's effectiveness participant compliance. It combines PHI familial cases multiparametric MRI those with pathogenic DNA repair (DRG) variants. Methods: non-profit charity-funded (AIRC - Fondazione AIRC project IG 2020 ID 25027) evaluates...
626 Background: The aim of the current study is to evaluate safety, tolerability, and efficacy neoadjuvant MMC in patients (pts) with non-muscle invasive bladder cancer (NMIBC). Methods: This a prospective phase III randomized clinical trial pts primary diagnosis urinary or secondary recurrent untreated since May 2022 September 2023 (EudraCT 2021-003751-42_studio ICH-013-). Pts are 1:1 arm (neoA) standard (StA). In 2 weeks before scheduled TUR (day 0) neoA receive intravesical instillations...
Abstract Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide, and there critical need for more effective treatments. The development new therapies, especially those aiming to modulate the tumor microenvironment (TME), limited by lack in vitro vivo models that recapitulate complexity TME spatial architecture HCC. Here, we aimed establish an HCC model assess treatment response hepatotoxicity selected drugs ex culturing fresh human liver tissue...
Patients with pT1 high-grade (HG) bladder cancer (BC) and a very high risk of progression might benefit from immediate radical cystectomy (RC), but this option remains controversial. Validation standardized method to evaluate the extent lamina propria (LP) invasion (with recognized prognostic value) in transurethral resections (TURBT) specimens is still needed. The Rete Oncologica Lombarda (ROL) system showed predictive value for after TURBT recent retrospective studies. Our aim was validate...
Myoepithelial carcinoma (MC), also known as malignant myoepithelioma, shows an infiltrative and destructive growth [1]. neoplasms account for about 1.5% of all salivary tumors, MC is even more rare, representing 10% myoepitheliomas [1–3] with a reported incidence 0.2% gland tumors. In this case, the cytological diagnosis (pleomorphic adenoma) negative lymph nodes, addressed surgeon parotidectomy, following guidelines literature [27]. The best treatment huge, relapsing notwithstanding...