A5018534426- CAR-T cell therapy research
- Hematopoietic Stem Cell Transplantation
- Chronic Myeloid Leukemia Treatments
- Molecular Biology Techniques and Applications
- Immunotherapy and Immune Responses
- Mesenchymal stem cell research
- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Cancer Immunotherapy and Biomarkers
- HER2/EGFR in Cancer Research
- Cell Adhesion Molecules Research
- vaccines and immunoinformatics approaches
- Pluripotent Stem Cells Research
- T-cell and Retrovirus Studies
- Chronic Lymphocytic Leukemia Research
- Cancer-related Molecular Pathways
- AI in cancer detection
- Viral-associated cancers and disorders
- Retinoids in leukemia and cellular processes
- Angiogenesis and VEGF in Cancer
- Brain Metastases and Treatment
- Intensive Care Unit Cognitive Disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Anesthesia and Sedative Agents
- Cutaneous lymphoproliferative disorders research
University of Alberta
1973-2024
Gilead Sciences (United States)
2023
Humanitas University
2020-2021
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2021
Bristol-Myers Squibb (United States)
2018-2021
University of Arizona
2020
Seagen (United States)
2019
Australasian Leukaemia and Lymphoma Group
2019
Columbia University
2019
Population Services International
2011
Recent findings have indicated that TP53 inactivation in sarcomas may result from mutation and/or deletion of the gene or, alternatively, binding to MDM2 products. To investigate further a possible role two genes sarcomas, 24 large and deep-seated lipomas 74 liposarcomas various subtypes were analysed for mdm2 p53 overexpression by immunocytochemistry. Nineteen cases same series also molecularly both amplification mutations, ten non-random chromosomal abnormalities. In retroperitoneal...
Eighteen patients with appreciable obstructive lung disease and 18 without measurable mechanical impairment were given intravenous diazepam to permit endoscopy. Doses of required for comparable level anesthesia used. There was an increase in the heart rate, there decreases blood pressure, stroke volume, left ventricular work, cardiac output normal pulmonary function. Total peripheral resistance elevated after 15 minutes. In disease, produced insignificant changes diastolic total resistance....
Expansion of stem cells from cord blood has been demonstrated to increase the numbers CD34+ cells, subsets, long-term culture-initiating and severe combined immunodeficient mouse, repopulating cells. However, reports suggest that ex vivo expanded population behaves differently than freshly isolated shows a delayed or diminished engraftment. In this study, we investigated effects cytokines flt3 ligand, cell factor, thrombopoietin on expansion CD34+/CD38− addition, studied expression adhesion...
The recent availability of the monoclonal antibody MIB-1 (which is able to detect human nuclear cell proliferation-associated antigen Ki-67 even on formalin-fixed, paraffin-embedded sections, microwave-treated and routinely processed for immunohistochemistry) could open new avenues validation clinical role tumour proliferation large, consecutive unselected series tumours. However, routine use such a marker requires methodological standardization as well comparative assessment some technical...
Abstract The recent availability of the monoclonal antibody MIB‐1 (which is able to detect human nuclear cell proliferation‐associated antigen Ki‐67 even on formalin‐fixed, paraffin‐embedded sections, microwave‐treated and routinely processed for immunohistochemistry) could open new avenues validation clinical role tumour proliferation large, consecutive unselected series tumours. However, routine use such a marker requires methodological standardization as well comparative assessment some...
Transition to digital pathology usually takes months or years be completed. We were familiarizing ourselves with solutions at the time when COVID-19 outbreak forced us embark on an abrupt transition pathology.
Abstract The microenvironment in the haematopoietic organs plays an important role regulating and sustaining differentiation self‐renewal of stem cells. Although crucial for cell maintenance homing, stromal cell—stem interactions are poorly understood. Here we show that ICAM‐like molecule is responsible adhesion to cells vitro . was characterized by a monoclonal antibody 3E 10 Immunoblotting results indicated had electrophoretic mobility equal intercellular molecule‐1 (ICAM‐1). Binding...
Introduction: Brentuximab vedotin (BV), an antibody-drug conjugate targeting CD30, has been evaluated in multiple trials patients (pts) with peripheral T-cell lymphoma (PTCL), cutaneous (CTCL), or B-cell lymphoma. We examined the ability of CD30 expression level to predict response BV across these patient populations. Methods: Data were integrated from 275 pts PTCL, CTCL, and treated 5 prospective clinical trials. Study SGN35-012 plus rituximab monotherapy relapsed/refractory non-Hodgkin The...
Eight patients with cutaneous metastatic melanoma were submitted to high-dose intravenous thymopentin (TP5) treatment for 5 weeks: three received 1 g times a week, daily and two 2 daily. Four out of eight presented partial response lesions lasting 1–7 months, six remain alive evidence disease after follow-up 2–7 months. A remarkable histologic observation is the presence tumour necrosis, which was seen as both single cells large confluent areas. The majority lymphoid present in are CD45RO+...
ABSTRACT This poster presents a community‐focused participatory design methodology as basis for developing digital storytelling system the Inuvialuit Settlement Region in Canada's Western Arctic. It provides an overview of various stages prototype informed by elder's gathering and community experience open house. Among redesign ideas are empathy maps we using to allow us connect stories with designs needs mind.
Recent findings have indicated that TP53 inactivation in sarcomas may result from mutation and/or deletion of the gene or, alternatively, binding to MDM2 products. To investigate further a possible role two genes sarcomas, 24 large and deep-seated lipomas 74 liposarcomas various subtypes were analysed for mdm2 p53 overexpression by immunocytochemistry. Nineteen cases same series also molecularly both amplification mutations, ten non-random chromosomal abnormalities. In retroperitoneal...
Background Most vaccines are delivered into the muscle although it contains very few potent antigen presenting cells, such as dendritic cells (DCs) that critical for driving adaptive immune responses. Understanding early mechanisms dictate vaccine responses and why some adjuvants like oil-in-water emulsion MF59 shown to be more than alum is important design of new vaccines. Here, we investigated recruitment injection site uptake a clinically relevant HIV-1 envelope glycoprotein (Env) in...