OBJECTIVES: To evaluate the effect of pharmaceutical care provided in addition to acute Geriatric Evaluation and Management (GEM) on appropriateness prescribing. DESIGN: Randomized, controlled trial, with patient as unit randomization. SETTING: Acute GEM unit. PARTICIPANTS: Two hundred three patients aged 70 older. INTERVENTION: Pharmaceutical from admission discharge by a specialist clinical pharmacist who had direct contacts team patients. MEASUREMENTS: Appropriateness prescribing...

To compare the peak intensity of typical small-sided games (SSGs) with those official matches in terms running demands and mechanical work (MechW) over different rolling average durations playing positions.Data were collected 21 players (25 [5] y, 181 [7] cm, 77 kg) belonging to an elite French football team. SSG data 2 seasons during training sessions (249 files, 12 [4] per player) (n = 12). Players' locomotor activity was recorded using 5-Hz Global Positioning System. Total distance (m),...

The transport equation describing the flow of solute across a membrane has been modified on basis theoretical studies calculating drag sphere moving in viscous liquid undergoing Poiseuille inside cylinder. It is shown that different frictional resistance terms should be introduced to calculate contributions diffusion and convection. New sieving equations are derived r A(p)/Deltax (respectively, pore radius total area pores per unit path length). These provide better agreement than older...

Abstract Extended cure survival models enable to separate covariates that affect the long-term probability of an event (or survival) from those only affecting dynamics events short-term survival). We propose generalize bounded cumulative hazard model handle exogenous frequently changing values over time and jointly impacting long- survival. The selection penalty parameters tuning smoothness additive terms is a challenge in framework. A fast algorithm based on Laplace approximations Bayesian...

Although models developed directly to describe marginal distributions have become widespread in the analysis of repeated measurements, some their disadvantages are not well enough known. These include producing profile curves that correspond no possible individual, possibly showing a treatment is superior on average when it poorer for each individual subject, implicitly generating complex and implausible physiological explanations, including underdispersion subgroups, sometimes corresponding...

Abstract Accelerated failure time models with a shared random component are described, and used to evaluate the effect of explanatory factors different transplant centres on survival times following kidney transplantation. Different combinations distribution effects baseline hazard function considered fit such data is critically assessed. A mixture model that combines short‐ long‐term components then developed, which provides more flexible for function. The can incorporate variables in each...

Pre-ascent climbing route visual inspection (route preview) has been suggested as a key performance parameter although its role never verified experimentally. We examined the efficacy of this perceptual-cognitive skill on indoor sport performance. Twenty-nine male climbers, divided into intermediate, advanced and expert level groups, climbed two routes matching their and, where applicable, below level. At each level, one was with preview, participants benefited from 3-min pre-ascent...

Abstract This paper discusses a statistical modeling strategy based on extreme value theory to describe the behavior of an insurance portfolio, with particular emphasis large claims. The is illustrated using 1991–92 group medical claims database maintained by Society Actuaries. Using theory, focuses "excesses over threshold" approach fit generalized Pareto distributions. proposed compared standard parametric gamma, lognormal, and log-gamma Extreme outperforms classical fits allows actuary...

A new model for multivariate non-normal longitudinal data is proposed. In a first step, each series of corresponding to given response modelled separately using copula relate the marginal distributions at time observation. second observation time, conditional (on past) are related another describing relationship between variables. Note that there no need consider same family these The technique illustrated in dose titration safety study on antidepressant. haemodynamic effect diastolic blood...

This study compares the effects of conventional controlled-rate freezing and vitrification on morphology metabolism in vitro-produced bovine blastocysts. Day 7 expanded blastocysts cultured synthetic oviduct fluid with 5% fetal calf serum were frozen 1.36 M glycerol, 0.25 sucrose or vitrified 25% ethylene glycol. Cell alterations vitro development evaluated immediately after thawing 72 h. The effect cryopreservation inner cell mass trophectoderm (TE) number as well glucose, pyruvate, oxygen...

Cet article propose une première analyse et édition de trois documents méconnus produits à l’abbaye Saint-Rigaud – com. Ligny-en-Brionnais, dép. Saône-et-Loire durant le dernier tiers du xie siècle. Ces font partie la catégorie diplomatique des « pancartes ». Ils prennent forme grandes feuilles parchemin sur lesquelles on transcrivit au moins deux actes dont les originaux ont aujourd’hui disparu. L’examen ces selon axes conservation archivistique, principes composition signification sociale...

Abstract Principal Component Analysis (PCA) is a classical technique in statistical data analysis, feature extraction and reduction, aiming at explaining observed signals as linear combination of orthogonal principal components. Independent (ICA) array processing recovering unobserved or ‘sources’ from mixtures, exploiting only the assumption mutual independence between signals. The separation sources by ICA has great potential applications such sound (like voices mixed simultaneous multiple...

To examine in elite soccer players after traveling across 6 time zones some psychometric and physiological responses to a competitive camp the heat.Data from 12 professional (24.6 ± 5.3 y) were analyzed. They participated an 8-d preseason summer training Asia (heat index 34.9°C 2.4°C). Players' activity was collected during all sessions friendly game using 15-Hz GPS. Perceived training/playing load estimated session rating of perceived exertion (RPE) training/match duration. Psychometric...