A5032156161- Histone Deacetylase Inhibitors Research
- Alzheimer's disease research and treatments
- Epigenetics and DNA Methylation
- Cholinesterase and Neurodegenerative Diseases
- Genetics and Neurodevelopmental Disorders
- Dialysis and Renal Disease Management
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Child Nutrition and Water Access
- Nuclear Receptors and Signaling
- Birth, Development, and Health
- ATP Synthase and ATPases Research
- Signaling Pathways in Disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Computational Drug Discovery Methods
- Radiation Effects and Dosimetry
- Renal Transplantation Outcomes and Treatments
- Mitochondrial Function and Pathology
- RNA Research and Splicing
- RNA regulation and disease
- Amyotrophic Lateral Sclerosis Research
- RNA modifications and cancer
- GDF15 and Related Biomarkers
- Genetic Neurodegenerative Diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
Translational Therapeutics (United States)
2025
University of Pennsylvania
2025
Drexel University
2020-2023
Mohanlal Sukhadia University
2022
Martin Luther University Halle-Wittenberg
2018
Université de Reims Champagne-Ardenne
2018
Centre Hospitalier Universitaire de Reims
2018
Amity University
2016-2017
University of Virginia
1996
Institute of Nuclear Medicine & Allied Sciences
1985
The severity of Alzheimer's disease (AD) progression involves a complex interplay genetics, age, and environmental factors orchestrated by histone acetyltransferase (HAT)-mediated neuroepigenetic mechanisms. While disruption Tip60 HAT action in neural gene control is implicated AD, alternative mechanisms underlying function remain unexplored. Here, we report novel RNA binding for addition to its function. We show that preferentially interacts with pre-mRNAs emanating from chromatin targets...
Colorectal cancer incidences are on a rise in India. In this study, we have analyzed the mutation frequencies of six potential biomarkers, their coexistence, association with clinicopathological characteristics, and tumor location Indian colorectal patients. Next-generation sequencing was performed to identify mutations biomarker genes using formalin-fixed paraffin-embedded tissue blocks 112 The frequency observed KRAS, BRAF, PIK3CA, NRAS, TP53, APC 35.7%, 7.1%, 16.1%, 6.3%, 39.3%, 29.5%,...
Abstract Epigenetic dysregulation is a common mechanism shared by molecularly and clinically heterogenous neurodegenerative diseases (NDs). Histone acetylation homeostasis, maintained the antagonistic activity of histone acetyltransferases (HATs) deacetylases (HDACs), necessary for appropriate gene expression neuronal function. Disruption neural homeostasis has been implicated in multiple types NDs including Alzheimer’s disease (AD), yet mechanisms underlying alterations remain unclear. We...
Glutamate excitotoxicity is causal in striatal neurodegeneration underlying motor dysfunction and cognitive deficits Huntington's disease (HD). Excitatory amino acid transporter 2 (EAAT2), the predominant glutamate accounting for >90% of transport, plays a key role preventing by clearing excess from intrasynaptic cleft. Accordingly, EAAT2 has emerged as promising therapeutic target prevention neuronal HD other neurodegenerative diseases.We have previously designed novel positive allosteric...
Disruption of histone acetylation-mediated gene control is a critical step in Alzheimer's Disease (AD), yet chromatin analysis antagonistic acetyltransferases (HATs) and deacetylases (HDACs) causing these alterations remains uncharacterized. We report the first Tip60 HAT versus HDAC2 (ChIP-seq) transcriptional (RNA-seq) profiling study Drosophila melanogaster brains that model early human AD. find predominantly recruited to identical neuronal genes. Moreover, AD exhibit robust genome-wide...
<b><i>Background/Aims:</i></b> We compare conventional office blood pressure measurements with automated SPRINT-study type readings in kidney transplant recipients order to determine the impact of white coat effect a prospective observational study. <b><i>Methods:</i></b> Adult patients functional renal not dependent on dialysis were eligible. Readings taken presence physician an oscillometric method. Afterwards, repeated resting alone quiet...
ABSTRACT Disruption of histone acetylation mediated gene control is a critical step in Alzheimer’s Disease (AD), yet chromatin analysis antagonistic acetyltransferases (HATs) and deacetylases (HDACs) causing these alterations remains uncharacterized. We report the first Tip60 HAT versus HDAC2 transcriptional profiling study Drosophila brains that model early human AD. find predominantly recruited to identical neuronal genes. Moreover, AD exhibit robust genome-wide include enhanced reduced...
Abstract Background Alzheimer’s Disease (AD) etiology involves a complex interplay of genetics, age, and environmental factors that influence neuroepigenetic mediated neural gene control. Reduced histone acetylation in the AD brain is widespread hallmark underlying repression cognitive impairment etiology. As dynamically regulated by antagonistic deacetylases (HDACs) acetyltransferases (HATs), pharmacological treatments aiming to restore via HDAC inhibition are research hotspot for...
Dose response relationships of creatine, creatinie excretions and their ratio in 24 hr urine samples have been studied on each individual day upto 4 days after 1-7 Gy whole body gamma irradiation to rats. Creatine excretion reaches the peak 2nd while creatinine first a plateau is maintained 4th case. Good dose correlationship for creatine or levels 3rd day. Seperate curves are needed using these parameters biological dosimetry purpose. Administration radioprotectors viz., combination...
ABSTRACT Alzheimer’s disease (AD) is an age-related neurodegenerative disorder hallmarked by amyloid-β (Aβ) plaque accumulation, neuronal cell death, and cognitive deficits that worsen during progression. Histone acetylation dysregulation, caused imbalance between reduced histone acetyltransferases (HAT) Tip60 increased deacetylase 2 (HDAC2) levels, can directly contribute to AD pathology. However, whether such AD-associated neuroepigenetic alterations occur in response Aβ peptide production...