A5010794637- Neuroendocrine Tumor Research Advances
- Organ Transplantation Techniques and Outcomes
- Pancreatic and Hepatic Oncology Research
- Neuroblastoma Research and Treatments
- Thyroid and Parathyroid Surgery
- Adrenal and Paraganglionic Tumors
- Parathyroid Disorders and Treatments
- Liver Disease and Transplantation
- Pituitary Gland Disorders and Treatments
- Hormonal Regulation and Hypertension
- Lung Cancer Research Studies
- Magnesium in Health and Disease
- Cancer, Hypoxia, and Metabolism
- Liver physiology and pathology
- Thyroid Cancer Diagnosis and Treatment
- Head and Neck Anomalies
- Voice and Speech Disorders
- Renal Transplantation Outcomes and Treatments
- Pancreatitis Pathology and Treatment
- Gastrointestinal disorders and treatments
- Liver Disease Diagnosis and Treatment
- Genital Health and Disease
- Acute Lymphoblastic Leukemia research
- 3D Printing in Biomedical Research
- Airway Management and Intubation Techniques
Charité - Universitätsmedizin Berlin
2012-2025
Humboldt-Universität zu Berlin
2007-2025
Freie Universität Berlin
2020-2025
Royal College of Surgeons of England
2008
In Brief Objective: Patients undergoing pancreas resection carry several risk factors for nosocomial bacterial infections. Pre- and probiotics (synbiotics) are potentially useful prevention of these Summary Background Data: First trials in patients following major abdominal surgery including liver transplantation using one Lactobacillus (LAB) fiber showed significant reduction infection rates reduced length antibiotic therapy compared with a control group. The present study was designed to...
Hemostasis is a central issue in laparoscopic surgery. Ultrasonic scissors and bipolar clamps are commonly used, with known advantages each technique. The prototype of new surgical scissors, delivering ultrasonically generated frictional heat energy simultaneously (THUNDERBEAT® [TB]), was compared to ultrasonic (Harmonic ACE® [HA]) an advanced device (LigaSure® [LS]) using pig model. As safety parameters, temperature profiles after single activation defined cut were determined. efficacy seal...
Abstract Background Anaplastic thyroid cancer (ATC) is a rare and aggressive neoplasm. We still lack effective treatment options, so survival rates remain very low. Here, we aimed to evaluate the activity of combination lenvatinib pembrolizumab as systemic first-line therapy in ATC. Methods In retrospective analysis, investigated tolerability combined (starting dose 14 24 mg daily) (200 every three weeks) an institutional cohort ATC patients. Results Five patients with metastatic received...
Necrosis in postoperative histology has been reported as being specific for adrenocortical carcinoma (ACC) compared to adenoma. We therefore retrospectively analyzed the diagnostic accuracy of finding necrosis preoperative cross-sectional imaging and a marker ACC our patient cohort. Among 411 adrenalectomies 396 patients performed between 2008 April 2022, 30 cases (7.6%) were identified, with one tumor measuring less than 40 mm excluded. All 45 benign tumors at least diameter, including...
European and German consensus guidelines advocate preoperative therapy with α-adrenoreceptor antagonists in symptomatic patients catecholamine-producing pheochromocytomas paragangliomas (PPGLs) to avoid hypertensive crisis during adrenalectomy. This practice has been questioned recently. work aimed assess current management of PPGLs across disciplines. The study was conducted from November 2023 February 2024 using the Delphi technique. Two consecutive surveys were conceived by a steering...
<sec> <title>BACKGROUND</title> Thyroid surgery entails significant challenges due to the intricate anatomical structure of region, including recurrent laryngeal nerve and parathyroids. </sec> <title>OBJECTIVE</title> To support training resident surgeons through development a virtual reality simulator for thyroid surgery. <title>METHODS</title> We created an model integrating structures segmented from CT data with manually inserted elements not clearly visible in scans (e.g., nerves,...
Acinar cell carcinomas (ACC) belong to the exocrine pancreatic malignancies. Due their rarity, there is no consensus regarding treatment strategies for resectable ACC.This a retrospective multicentric study of radically resected pure ACC. Primary endpoints were overall survival (OS) and disease-free (DFS). Further oncologic outcomes related tumor stage therapeutic protocols.59 patients (44 men) with median age 64 years included. The size was 45.0 mm. 61.0% pT3 (n = 36), nodal positivity rate...
Adrenal metastasis of hepatocellular carcinoma (HCC) is a rare entity and can be treated by resection, local ablative therapy, or systemic therapy. Unfortunately, data about treatment outcome, especially in liver transplant recipients, are rare. From 2005 to 2015, 990 resections 303 transplantations because HCC were performed at our clinic. We retrospectively analyzed outcome the patients with metachronous adrenal HCC, who received either ablation, surveillance only. 10 identified (0.8%). 7...
Patients with small intestinal neuroendocrine tumors (siNETs) frequently present emergently due to bowel ischemia or obstruction. The influence of emergency surgery on the prognosis siNET remains controversial. aim this study was investigate association between type presentation (emergency/elective) and oncological outcome.
Background: Rapid quantification of liver metastasis for diagnosis and follow-up is an unmet medical need in patients with secondary malignancies. We present a 3D-quantification model neuroendocrine metastases (NELM) using gadoxetic-acid (Gd-EOB)-enhanced MRI as useful tool multidisciplinary cancer conferences (MCC). Methods: Manual 3D-segmentations NELM livers (149 278 Gd-EOB scans) were used to train neural network (U-Net architecture). Clinical usefulness was evaluated another 33 who...
<b><i>Introduction:</i></b> Gender has been proven to influence the pathophysiology and treatment of numerous diseases, including kidney diseases hormonal dysfunction like hyperparathyroidism. Thus, higher parathormone levels have demonstrated in women with end-stage disease, when compared men. <b><i>Objectives:</i></b> We questioned whether female gender is associated an increased risk for parathyroid nodular hyperplasia necessary...
Cellular therapies require methods for noninvasive visualization of transplanted cells. Micron-sized iron oxide particles (MPIOs) generate a strong contrast in magnetic resonance imaging (MRI) and are therefore ideally suited as an intracellular agent to image cells under clinical conditions. However, MPIOs were previously not applicable use. Here, we present the development evaluation silica-based micron-sized (sMPIOs) with functionalizable particle surface. Particles magnetite content >40%...
Abstract Purpose Neuroendocrine tumors of the small intestine (si-NET) describe a heterogenous group neoplasms. Based on Ki67 proliferation index si-NET are divided into G1 (Ki67 < 2%), G2 3–20%) and rarely G3 > 20%) tumors. However, few studies evaluate impact tumor grading prognosis in si-NET. Moreover, can form distinct lymphatic spread patterns to mesenteric root, aortocaval lymph nodes, distant organs. This study aims identify prognostic factors within grading. Methods...
For the histopathological work-up of resected neuroendocrine tumors small intestine (siNET), determination lymphatic (LI), microvascular (VI) and perineural (PnI) invasion is recommended. Their association with poorer prognosis has already been demonstrated in many tumor entities. However, influence LI, VI PnI siNET not sufficiently described yet. A retrospective analysis all patients treated for at ENETS Center Excellence Charité-Universitätsmedizin Berlin, from 2010 to 2020 was performed...
Background and Aims: There are only few data on the influence of cinacalcet outcome parathyroidectomy in patients with renal hyperparathyroidism. Indication timing surgery have changed since its introduction, especially regard to kidney transplantation. Therefore, we retrospectively analyzed undergoing for hyperparathyroidism our institution. Material methods: Between 2008 2015, 196 consecutive operations 191 were analyzed. About 80 (41%) performed receiving compared 116 (59%) without...