A5101624313- Microbial Natural Products and Biosynthesis
- Fungal Biology and Applications
- Geochemistry and Elemental Analysis
- Paleontology and Stratigraphy of Fossils
- Geological and Geochemical Analysis
- Phytochemistry and Biological Activities
- Biological and pharmacological studies of plants
- Plant Pathogens and Fungal Diseases
- Geochemistry and Geologic Mapping
- Chemical synthesis and alkaloids
- Remote-Sensing Image Classification
- Synthesis and Biological Activity
- Radioactive element chemistry and processing
- Mycotoxins in Agriculture and Food
- Natural Compound Pharmacology Studies
- Plant Molecular Biology Research
- Microbial Metabolic Engineering and Bioproduction
- Phytochemical compounds biological activities
- Plant chemical constituents analysis
- Urban Heat Island Mitigation
- Heart Failure Treatment and Management
- Plant biochemistry and biosynthesis
- Plant Gene Expression Analysis
- Pesticide Exposure and Toxicity
- Phytochemistry and biological activity of medicinal plants
Yunnan University
2013-2025
Second People's Hospital of Yunnan Province
2025
Minzu University of China
2015-2023
Yunnan Institute of Environmental Sciences
2023
Shandong First Medical University
2023
Binzhou University
2023
Binzhou People's Hospital
2023
State Ethnic Affairs Commission
2013-2022
Chinese Academy of Sciences
2019-2022
Shanghai First People's Hospital
2022
Gastric signet ring cell carcinoma (GSRC) is a special subtype of gastric cancer (GC) associated with poor prognosis, but an in-depth and systematic study GSRC lacking. Here, we perform single-cell RNA sequencing to assess GC samples. We identify (SRCC) cells. Microseminoprotein-beta (MSMB) can be used as marker gene guide the identification moderately/poorly differentiated adenocarcinoma (SRCC). The upregulated differentially expressed genes in SRCC cells are mainly enriched abnormally...
Oryzaeins A–D (<b>1</b>-<b>4</b>), four new isocoumarin derivatives, along with five known ones (<b>5</b>-<b>9</b>) were isolated from solid cultures of an endophytic fungus <i>Aspergillus oryzae</i>. Their structures elucidated by detailed spectroscopic analysis and comparison reported data related derivatives. Among them, compounds <b>1</b> <b>2</b> represent the first examples isocoumarins possessing unusual 2-oxopropyl group a rare 3-hydroxypropyl group. Compounds displayed moderate...
Phaseolus vulgaris L. is rich in alpha-amylase inhibitor and has been used for reducing glycemia calories absorption through preventing or delaying the digestion of complex carbohydrate. A randomized, double-blinded, placebo-controlled study was conducted on obese volunteers to evaluate degree significate weight loss by regular intake cultivated from Southwestern region China.The were divided into two groups, homogeneous age, gender, body weight. extract placebo given 2,400 mg per day before...
"Old phosphorite" deposits (Ediacaran to early Cambrian) located in Central Guizhou, South China, are hosted carbonate and represent the earliest phosphogenesis. These old phosphorites, as well Pliocene Pleistocene modern phosphate sediments (recent phosphorite) have been extensively studied. However, possibility of recent phosphorite being incipient stage long-time remains uncertain. Taking Weng'an (Ediacaran) Zhijin (early phosphorites examples, this study conducted situ geochemical...
Versicolactones A–D (<b>1</b>–<b>4</b>), four new butyrolactones, along with known butyrolactones (<b>5</b>–<b>8</b>) were isolated from the fermentation products of endophytic fungus <i>Aspergillus versicolor</i>. The structures compounds <b>1</b>–<b>4</b>, including absolute configuration, elucidated by interpretation NMR and CD data. Compound <b>2</b> was further confirmed single-crystal X-ray diffraction analysis. In particular, compound <b>1</b> is first naturally occurring...
Chaperone-mediated autophagy (CMA) is involved in wild-type α-synuclein degradation Parkinson’s disease (PD), and LAMP2A Hsc 70 have recently been indicated to be deregulated by microRNAs. To recognize the regularory role of miR-320a CMA possible degradation, present study, we examined targeting regulating miR-320 expression. We first constructed an α-synuclein-overexpressed human neuroblastoma cell line, SH-SY5Y-Syn(+), stably over-expressing sensitive inhibitor, which exerted no effect on...
• Phosphate oxygen and Mo isotope of Ediacaran phosphorite were firstly reported. Combination terrigenous weathering upwelling waters provided both P REEs. Terrigenous main REY in Cambrian Zhijin deposit. Redox evolution enabled phosphorites to be formed by different mechanisms. Phosphogenic model combining origins formation mechanism was formed. Large deposits Central Guizhou, China, around the Precambrian/Cambrian boundary (PC/C), including (Doushantuo stage) early (Gezhongwu stage). Among...
Visceral fat (VF) was proved to be a more precise predictor of atherosclerotic cardiovascular disease (ASCVD) risk in individuals with type 2 diabetes mellitus (T2DM) than body mass index (BMI) itself. Even when the BMI normal, visceral area (VFA) ≥ 90 cm² could raise ten-year developing ASCVD. Therefore, it worth evaluating association influencing factors high VF non-obese T2DM individuals. This study enrolled 1,409 participants T2DM, whom 538 had normal BMI. Based on VFA, these subjects...
The immunoactivity was evaluated of Dendrobium officinale Kimura & Migo, a Chinese herbal plant, and its crude polysaccharides. Different dosages D. polysaccharides were orally administered to healthy BALB/c mice. control group given distilled water. After 4 weeks, immune parameters, including cellular immunity (delayed-type hypersensitivity natural killer cell activity), humoral (serum hemolytic complement nonspecific (peritoneal macrophage phagocytosis) interferon-γ production by...
Alteration minerals are important prospecting indicators, and multispectral hyperspectral remote sensing technologies tools. Multispectral data such as ASTER have been widely used for extracting alteration mineral information. The dataset is easy to access, cost-effective use, rich in rock ore spectrum Recently, the use of identification technology satellite fine has become feasible China, considering development technology, especially launch ZY1-02D China. Pulang porphyry copper deposit,...
Organophosphorus pesticides are the most widely used in modern agricultural systems to ensure good harvests. Isocarbophos (ICP), with a potent acetylcholinesterase inhibitory effect is utilized control variety of leaf-eating and soil insects. However, characteristics bioactivation detoxification ICP humans remain unclear. In this study, oxidative metabolism, esterase hydrolysis, chiral inversion human liver microsomes (HLMs) were investigated aid stereoselective LC/MS/MS method. The...
The geochemistry of rare earth elements and yttrium (REY) in phosphorite has been widely studied. However, the effect organic matter on REY enrichment not well determined. We utilized paired inorganic (δ13Ccarb) carbon isotopes, total (TOC), content (∑REY) Zhijin Motianchong (MTC) compared them with those Meishucun (MSC) to reveal REY. δ13Ccarb MTC area (≈0‰) is heavier than that MSC (−5.23‰ −1.13‰), whereas δ13Corg lighter (−33.85‰ −26.34‰) (−32.95‰ −25.50‰). Decoupled indicate contribution...
Thermal infrared remote sensing (TIRS) technology is intriguing for geothermal anomaly detection due to its time efficiency and cost-effectiveness. Land surface temperature (LST) derived from TIRS indicates potential anomalies. However, LST on different natural features, exhibiting relatively cold/hot anomalies in daytime nighttime, affected the identification of abnormal areas. The aim this study was highlight anomalous areas by integrating multi-view nighttime data. Specifically, winter...