A5103107730- SARS-CoV-2 and COVID-19 Research
- interferon and immune responses
- COVID-19 Clinical Research Studies
- RNA and protein synthesis mechanisms
- Peptidase Inhibition and Analysis
- Poxvirus research and outbreaks
- Lung Cancer Research Studies
- Herpesvirus Infections and Treatments
University of Sharjah
2025
Technical University of Munich
2020-2024
The severe-acute-respiratory-syndrome-coronavirus-2 (SARS-CoV-2) is the causative agent of COVID-19, but host cell factors contributing to COVID-19 pathogenesis remain only partly understood. We identify metalloprotease ADAM17 as a facilitator SARS-CoV-2 entry and ADAM10 factor required for lung syncytia formation, hallmark pathology. ADAM17, which are broadly expressed in human lung, cleave spike protein (S) vitro, indicating that contribute priming S, an essential step viral fusion. ADAM...
Summary The global emergence of SARS-CoV-2 urgently requires an in-depth understanding molecular functions viral proteins and their interactions with the host proteome. Several individual omics studies have extended our knowledge COVID-19 pathophysiology 1–10 . Integration such datasets to obtain a holistic view virus-host define pathogenic properties is limited by heterogeneity experimental systems. We therefore conducted concurrent multi-omics study SARS-CoV. Using state-of-the-art...
Multiple omics analyzes of Vaccinia virus (VACV) infection have defined molecular characteristics poxvirus biology. However, little is known about the monkeypox (mpox) (MPXV) in humans, which has a different disease manifestation despite its high sequence similarity to VACV. Here, we perform an in-depth multi-omics analysis transcriptome, proteome, and phosphoproteome signatures MPXV-infected primary human fibroblasts gain insights into virus-host interplay. In addition expected...