A5007276141- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Aortic Disease and Treatment Approaches
- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Congenital Heart Disease Studies
- Fuel Cells and Related Materials
- Hydraulic and Pneumatic Systems
- Aortic aneurysm repair treatments
- Cardiac pacing and defibrillation studies
- Coronary Interventions and Diagnostics
- Elasticity and Material Modeling
- Cavitation Phenomena in Pumps
- Soft Robotics and Applications
- Respiratory Support and Mechanisms
- Turkey's Politics and Society
- Probabilistic and Robust Engineering Design
- Energy Load and Power Forecasting
- Automotive and Human Injury Biomechanics
- Heart Failure Treatment and Management
- Vehicle Noise and Vibration Control
- Intermetallics and Advanced Alloy Properties
- Traumatic Brain Injury Research
- Metal and Thin Film Mechanics
- Refrigeration and Air Conditioning Technologies
Massachusetts Institute of Technology
2021-2025
University of Southampton
2024-2025
Boston Children's Hospital
2024
Harvard University
2024
Beth Israel Deaconess Medical Center
2024
Massachusetts General Hospital
2024
Koç University
2018-2022
Antalya Bilim University
2018
University Hospital Bonn
2017
Cleveland State University
2013
Aortic stenosis (AS) affects about 1.5 million people in the United States and is associated with a 5-year survival rate of 20% if untreated. In these patients, aortic valve replacement performed to restore adequate hemodynamics alleviate symptoms. The development next-generation prosthetic valves seeks provide enhanced hemodynamic performance, durability, long-term safety, emphasizing need for high-fidelity testing platforms devices. We propose soft robotic model that recapitulates...
Abstract The increasing recognition of the right ventricle (RV) necessitates development RV-focused interventions, devices and testbeds. In this study, we developed a soft robotic model heart that accurately mimics RV biomechanics hemodynamics, including free wall, septal valve motion. This uses biohybrid approach, combining chemically treated endocardial scaffold with synthetic myocardium. When connected to circulatory flow loop, (RRV) replicates real-time hemodynamic changes in healthy...
Our understanding of cardiac remodeling processes due to left ventricular pressure overload derives largely from animal models aortic banding. However, these studies fail enable control over both disease progression and reversal, hindering their clinical relevance. Here, we describe a method for progressive reversible banding based on an implantable expandable actuator that can be finely tuned modulate debanding in rat model. Through catheterization, imaging, histologic studies, demonstrate...
Impeller design has a significant impact on the overall performance of blood pump. In this study, effect blade curvature was investigated by performing in silico and vitro studies recently developed centrifugal pump.A computational fluid dynamics study performed for flow rates 3-5 L/min at 2000 r/min. The model also applied US Food Drug Administration (FDA) benchmark pump to validate our method. relative hemolysis index calculated with Eulerian estimation method five impellers wrap angles...
Abstract Soft robotic devices containing multiple actuating elements have successfully recapitulated complex biological motion, leading to their utility in biomedical applications. However, there are inherent nonlinear mechanics associated with soft composite materials where actuators embedded elastomeric matrices. Predicting overall behavior prior fabrication and subsequent experimental characterization can therefore present a hurdle the design process efficiently satisfying functional...
Tetralogy of Fallot is a congenital heart disease affecting newborns and involves stenosis the right ventricular outflow tract (RVOT). Surgical correction often widens RVOT with transannular enlargement patch, but this causes issues including pulmonary valve insufficiency progressive ventricle failure. A monocusp can prevent regurgitation; however, failure resulting from factors leaflet design, morphology, immune response occur, ultimately in insufficiency. multimodal platform to...
Abstract Heart failure with preserved ejection fraction (HFpEF) is a major challenge in cardiovascular medicine, accounting for ≈50% of all cases heart failure. Despite the ongoing efforts, no medical device has yet received FDA approval. This largely due to lack an vivo model HFpEF hemodynamics, resulting inability evaluate effectiveness prior clinical trials. Here, development highly tunable porcine hemodynamics described using implantable soft robotic sleeves, where controlled actuation...
Abstract In this work, a lumped‐parameter Windkessel model of the cardiovascular system that simulates biomechanical parameters human physiology is presented. The object‐oriented platform provided by MATLAB‐based modeling environment SIMSCAPE employed to compute blood pressures and flows in each heart chamber at various sites vascular tree. hydraulic domain allows determination hemodynamics intuitively from geometrical mechanical properties system, while custom elements pumping action...
Mechanical circulatory support (MCS) devices are currently under development to improve the physiology and hemodynamics of patients with heart failure preserved ejection fraction (HFpEF). Most these devices, however, designed provide continuous-flow support. While it has been shown that pulsatile may overcome some complications hindering clinical translation for other phenotypes, effects have on HFpEF still unknown. Here, we present a multi-domain simulation study pump device left atrial...
Abstract In the design of rotary blood pumps, optimization parameters plays an essential role in enhancing hydrodynamic performance and hemocompatibility. This study investigates influence volute tongue angle as a geometric parameter on hemodynamic characteristics pump. A numerical investigation five different versions designs is carried out by utilizing computational fluid dynamics (CFD) software ANSYS-FLUENT. The effect evaluated regarding performance, circumferential pressure...
Aortic stenosis (AS) is the most common valvular heart disease in developed countries. High-fidelity preclinical models can improve AS management by enabling therapeutic innovation, early diagnosis, and tailored treatment planning. However, their use currently limited complex workflows necessitating lengthy expert-driven manual operations. Here, we propose an AI-powered computational framework for accelerated democratized patient-specific modeling of hemodynamics from computed tomography....
Calcification has significant influence over cardiovascular diseases and interventions. Detailed characterization of calcification is thus desired for predictive modeling, but calcium deposits on structures are still often manually reconstructed physics-driven simulations. This poses a major bottleneck large-scale adoption computational simulations research or clinical use. To address this, we propose an end-to-end automated image-to-mesh algorithm that enables robust incorporation...
Scientific efforts in the field of computational modeling cardiovascular diseases have largely focused on heart failure with reduced ejection fraction (HFrEF), broadly overlooking preserved (HFpEF), which has more recently become a dominant form worldwide. Motivated by paucity HFpEF silico representations, two distinct models are presented this paper to simulate hemodynamics resulting from left ventricular pressure overload. First, an object-oriented lumped-parameter model was developed...
Herein, the computational modeling of a fluidic oscillator for use in an educational respiratory simulator apparatus is presented. The design provides realistic visualization and tuning biomechanics using part that (i) inexpensive, (ii) easily manufactured without need specialized equipment, (iii) simple to assemble maintain, (iv) does not require any electronics, (v) has no moving components could be prone failure. A fluid dynamics (CFD) model used assess flow characteristics system,...
Scientific efforts in the field of computational modeling cardiovascular diseases have largely focused on heart failure with reduced ejection fraction (HFrEF), broadly overlooking preserved (HFpEF), which has more recently become a dominant form worldwide. Motivated by paucity HFpEF silico representations, two distinct models are presented this paper to simulate hemodynamics resulting from left ventricular pressure overload. First, an object-oriented lumped-parameter model was developed...
Heart failure with preserved ejection fraction (HFpEF) is a major challenge in cardiovascular medicine, accounting for ≈50% of all cases heart failure.Despite the ongoing efforts, no medical device has yet received FDA approval.This largely due to lack an vivo model HFpEF hemodynamics, resulting inability evaluate effectiveness prior clinical trials.Here, development highly tunable porcine hemodynamics described using implantable soft robotic sleeves, where controlled actuation left...
Calcification has significant influence over cardiovascular diseases and interventions. Detailed characterization of calcification is thus desired for predictive modeling, but calcified heart meshes physics-driven simulations are still often reconstructed using manual operations. This poses a major bottleneck large-scale adoption computational research or clinical use. To address this, we propose an end-to-end automated meshing algorithm that enables robust incorporation patient-specific...
Abstract Aortic stenosis (AS) is the most common valvular heart disease in developed countries. High‐fidelity preclinical models can improve AS management by enabling therapeutic innovation, early diagnosis, and tailored treatment planning. However, their use currently limited complex workflows necessitating lengthy expert‐driven manual operations. Here, we propose an AI‐powered computational framework for accelerated democratized patient‐specific modeling of hemodynamics from computed...
Abstract Our understanding of cardiac remodeling processes due to left ventricular pressure overload derives largely from animal models aortic banding. However, these studies fail simultaneously enable control over disease progression and reversal, hindering their clinical relevance. Here, we describe a method for controlled, progressive, reversible banding based on an implantable expandable actuator that can be finely controlled modulate debanding in rat model. Through catheterization,...
A continuous-flow centrifugal blood pump system has been recently developed as an implantable left ventricular assist device for patients with endstage heart failure. The objective of this study was to evaluate the initial in vivo performance a newly (iHeart or Istanbul heart; Manufacturing and Automation Research Center, Koc University, Istanbul, Turkey) acute setting using pig model.