A5028132245- Cardiovascular Function and Risk Factors
- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Diabetes Treatment and Management
- Advanced Neuroimaging Techniques and Applications
- MRI in cancer diagnosis
- Diet and metabolism studies
- Aortic aneurysm repair treatments
- Cardiac Valve Diseases and Treatments
- Lanthanide and Transition Metal Complexes
- Aortic Disease and Treatment Approaches
- Cardiomyopathy and Myosin Studies
- Botulinum Toxin and Related Neurological Disorders
- Cardiovascular Issues in Pregnancy
- Cardiac Ischemia and Reperfusion
- Congenital heart defects research
- Adipose Tissue and Metabolism
- Cell Image Analysis Techniques
- Historical Medical Research and Treatments
- Radio Frequency Integrated Circuit Design
- Elasticity and Material Modeling
- Quality and Safety in Healthcare
- Clinical Laboratory Practices and Quality Control
- Pulmonary Hypertension Research and Treatments
- Atomic and Subatomic Physics Research
New York Institute of Technology
2023-2025
Massachusetts General Hospital
2021-2024
Athinoula A. Martinos Center for Biomedical Imaging
2021-2023
Cleveland Clinic
2023
Harvard University
2022-2023
Innovation Research Center
2023
Mercy Medical Center
1995
Background Late gadolinium enhancement cardiac magnetic resonance imaging is an effective and reproducible method for characterizing myocardial infarction. However, gadolinium‐based contrast agents are contraindicated in patients with acute chronic renal insufficiency. In addition, several recent studies have noted tissue deposition of free who undergone serial contrast‐enhanced imaging. There a clinical need alternative forms that acceptable the setting Methods Results Three days after 80...
To develop and assess a residual deep learning algorithm to accelerate in vivo cardiac diffusion-tensor MRI (DT-MRI) by reducing the number of averages while preserving image quality DT-MRI parameters.In this prospective study, denoising convolutional neural network (DnCNN) for was developed; total 26 participants, including 20 without obesity (body mass index [BMI] < 30 kg/m2; mean age, 28 years ± 3 [standard deviation]; 11 women) six with (BMI ≥ 48 11; five women), were recruited from June...
Abstract As one of the highest energy consumer organs in body, heart requires tremendous amount adenosine triphosphate (ATP) to maintain its continuous mechanical work. Fatty acids, glucose, and ketone bodies are primary fuel source generate ATP with perturbations generation possibly leading contractile dysfunction. Cardiac metabolic imaging magnetic resonance (MRI) plays a crucial role understanding dynamic changes occurring failing heart, where cardiac metabolism is deranged. Also,...
Purpose For in vivo cardiac DTI, breathing motion and B 0 field inhomogeneities produce misalignment geometric distortion diffusion‐weighted (DW) images acquired with conventional single‐shot EPI. We propose using a dimensionality reduction method to retrospectively estimate the respiratory phase of DW facilitate both correction (DisCo) compensation. Methods Free‐breathing electrocardiogram‐triggered whole left‐ventricular DTI second‐order motion‐compensated spin echo EPI sequence...
Both exercise-induced molecular mechanisms and physiological cardiac remodeling have been previously studied on a whole heart level. However, the regional microstructural tissue effects of these in yet to be spatially linked further elucidated. We show exercised mice that expression CITED4, transcriptional co-regulator necessary for cardioprotection, is regionally heterogenous with preferential significant increases lateral wall compared sedentary mice. Concordantly this same region, heart's...
Cardiomyocyte growth can occur in both physiological (exercised-induced) and pathological (e.g., volume overload pressure overload) conditions leading to left ventricular (LV) hypertrophy. Studies using animal models histology have demonstrated the remodeling process at organ level tissue-cellular level, respectively. However, driving factors of mechanistic link between organ, tissue, cellular remains poorly understood. Computational potential bridge this gap by constitutive that describe...
Molecular phenotyping by imaging of intact tissues has been used to reveal 3D molecular and structural coherence in tissue samples using clearing techniques. However, cardiac remains challenging for large-scale (>100 mm3) specimens due sample distortion. Thus, directly assessing microstructural geometric properties confounded distortion such as helicity limited. To combat distortion, we developed a passive CLARITY technique (Pocket CLARITY) that utilizes permeable cotton mesh pocket...
Introduction: Myocardial infarction (MI) is a major risk factor for the development of heart failure with reduce ejection fraction (HFrEF). While previous studies have focused on HFrEF, role ketone bodies in MI unclear. Hypothesis: K etone may exert some cardioprotective effects following MI. Methods: Male Yorkshire pigs underwent percutaneous balloon occlusion LAD 80 minutes followed by 72 hours reperfusion period. Oral ester (BHB-butanediol monoester, KE, 550 mg/kg) or vehicle was...
Abstract Existing models of aortic stenosis (AS) are limited to inducing left ventricular pressure overload. As they have reduced control over the severity constriction, clinical relevance these is largely hindered by their inability mimic AS hemodynamics and recapitulate flow patterns associated with congenital valve defects, responsible for accelerated onset progression AS. Here we report development a highly tunable bio-inspired soft robotic tool that enables recapitulation in porcine...
For in-vivo cardiac diffusion-tensor MRI (DT-MRI), respiratory motion and B 0 field inhomogeneities produce misalignment geometric distortion in diffusion weighted images acquired with conventional single shot echo planar imaging. We propose using Laplacian Eigenmaps (LE), a dimensionality reduction method, to retrospectively estimate the phase of DWI facilitate both correction (DisCo) compensation (MoCo). LE-based DisCo MoCo reduces by 13.2% while producing computationally efficient image...
Cardiac MRI a powerful imaging modality to assess cardiac anatomy and function, its utility can be greatly enhanced with the use of contrast agents. Conventional agents are nephrotoxic which limits their utility. We evaluate novel agent is safe for in renal dysfunction. compare performance against that conventional porcine model ischemia-reperfusion. This demonstrates equivalent assessing myocardial fibrotic scars, indicating potential clinical workout patients impairment.