A5102009913- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- RNA modifications and cancer
- RNA Research and Splicing
- RNA Interference and Gene Delivery
- Mycobacterium research and diagnosis
- Nerve injury and regeneration
- Epigenetics and DNA Methylation
- Nerve Injury and Rehabilitation
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Signaling Pathways in Disease
- Protease and Inhibitor Mechanisms
- Dendrimers and Hyperbranched Polymers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Recommender Systems and Techniques
- Photodynamic Therapy Research Studies
- Transcranial Magnetic Stimulation Studies
- Heat shock proteins research
- Peroxisome Proliferator-Activated Receptors
- Advanced Drug Delivery Systems
- Traditional Chinese Medicine Analysis
Zhengzhou University
2021-2025
Hebei Agricultural University
2025
Institute of Process Engineering
2023
Heilongjiang University of Chinese Medicine
2023
Huashan Hospital
2018-2021
Fudan University
2018-2021
Second Affiliated Hospital of Jilin University
2017-2021
First Affiliated Hospital of Zhengzhou University
2019-2021
Xinxiang Central Hospital
2018-2021
First Affiliated Hospital of Xiamen University
2021
Cancer stem cells (CSCs) are believed to be responsible for the long‐term growth of a tumor, as well its metastasis and recurrence after conventional therapies. Here, it is demonstrated that sigma‐2 receptor overexpressed on surface breast CSCs, thus could serve biomarker purpose targeting. Breast CSCs targeted with Au nanocages (AuNCs) by functionalizing their surfaces SV119, synthetic small molecule capable binding high specificity. The interiors AuNCs also loaded an anticancer drug...
Breast cancer with metastasis especially brain represents a significant cause of morbidity and mortality in patients. In this study, we aimed to investigate the hub genes potential molecular mechanism breast cancer. Expression profiles were extracted from Gene Omnibus (GEO) database. GO KEGG pathway enrichment analyses conducted at Database for Annotation, Visualization, Integrated Discovery. Protein-protein interaction (PPI) network was established by STRING database constructed Cytoscape...
Background Breast cancer is a pivotal cause of global women death. Immunotherapy has become promising means to cure breast cancer. As constitutes immune microenvironment cancer, macrophages exert complicated functions in the tumour development and treatment. This study aims develop prognostic macrophage marker genes signature (MMGS).Methods Single cell RNA sequence data analysis was performed identify TCGA database used construct MMGS model as training cohort, GSE96058 dataset validate...
Accumulating evidence has uncovered long non-coding RNAs (lncRNAs) as central regulators in the pathogenesis of diverse human cancers including colorectal cancer (CRC). The present study discovered that a novel lncRNA ITIH4 antisense RNA 1 (ITIH4-AS1) was frequently under-expressed most normal tissues, colon tissues. Therefore, we aimed to investigate role ITIH4-AS1 CRC. Interestingly, significant overexpression observed CRC cell lines relative NCM460 cells. Also, investigated facilitating...
Paclitaxel prodrug based mixed micelles with high drug loading and tumor targeting capacity for elevated chemotherapy.
Abstract To construct a long noncoding RNA (lncRNA)–microRNA (miRNA)–messenger (mRNA) regulatory network related to epithelial ovarian cancer (EOC) cisplatin‐resistant, differentially expressed genes (DEGs), lncRNAs (DELs), and miRNAs (DEMs) between MDAH TOV‐112D cells lines were identified. Gene Ontology (GO) analysis Kyoto Encyclopedia of Genes Genomes (KEGG) pathway conducted analyze the biological functions DEGs. Downstream mRNAs or upstream for analyzed at miRTarBase 7.0 DIANA‐LncBase...
Aseptic loosening (AL) of artificial hip joints is the most common complication following replacement surgery. A total eight patients diagnosed with AL arthroplasty (THA) undergoing and control avascular necrosis femoral head (ANFH) or neck fracture THA were enrolled. The samples group from synovial tissue surrounding lining/head/neck prosthesis, synovium in joint cavity. present study utilized second‑generation high‑throughput sequencing mass spectrometry to detect differentially expressed...
Fish gill tissue is a primary organ responsive to acute oxygen deprivation or dissolved (DO) fluctuations in aquatic environments. However, the adaptive mechanism of crucian carp hypoxic stress remains largely unknown. Here, we investigated physiological and transcriptomic changes exposed conditions (dissolved concentration 0.6 ± 0.3 mg/L) for different durations (0 d, 1 2d, 3d, 4 5d). Transcriptomic analysis revealed that hypoxia group (0.6 mg/L DO) exhibited reduction interlamellar cell...
Long noncoding RNAs (lncRNAs) have been reported as essential regulators in osteosarcoma (OS), the most malignant bone tumor usually observed children and adolescents. In present study, we detected differentially expressed lncRNAs among OS tissues through RNA-sequencing. Then bioinformatics analysis, constructed aberrant regulatory networks, key-lncRNAs. We identified LINC01614 was significantly up-regulated tissues, which positively correlated with worse prognosis. Through related vitro...
Abstract Background Recently, overwhelming evidence supports that long noncoding RNAs (lncRNAs) play crucial roles in the occurrence and progression of tumors. However, role mechanism lncRNA TFAP2A-AS1 human gastric cancer (GC) remains unclear. Thus, biological regulatory mechanisms GC were explored. Methods Quantitative real-time PCR (qPCR) was applied to detect gene expression. Western blot used measure protein Cell proliferation migration determined by functional assays. Fluorescence situ...
The artifical cell system for the gene therapy of cancer might be a promising approach reversal neoplastic progress cells.
Purpose: Neuropathic pain (NP) is a challenging clinical problem due to its complex pathogenesis. In our previous study using microarray, we found that the levels of lncRNA Malat1 were decreased in spinal cord NP rat after brachial plexus avulsion, but contribution remain unclear. The purpose this was investigate role pathogenesis NP. Methods: model complete avulsion rat, cords harvested, and fluorescence situ hybridization (FISH) used test spatial expression qRT-PCR confirm quantitative...
Melanoma is an aggressive malignant skin tumor endangering the health of patients. Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) have been increasingly reported to be implicated in carcinogenesis melanoma. intergenic RNA 00665 (LINC00665) has found exert important regulatory roles some cancers, yet its function melanoma remains investigated. QRT-PCR analysis was conducted evaluate relative expression RNAs. Functional experiments vitro including colony formation, EdU, wound-healing...
Breast cancer (BC) is a common tumor that seriously affects women's physical/mental health and even life. BC invasion metastasis are still the main causes of mortality in patients. Exosomal long non-coding RNAs (exo-lncRNA) play an important role cell communication can help to understand better physiological pathological conditions result from BC. This study investigates new potential targets functions expression profiles exo-lncRNAs patients through high-throughput screening...
Cancer stem cells (CSCs) contribute to malignant features. Long non-coding RNA (LncRNA) FENDRR has been shown regulate tumor proliferation, migration, and invasion. However, the effects of on CSC-like traits colorectal cancer remain be elucidated. Here, we identified that lncRNA level was remarkably lower in spheres formed by compared parental cells. Further functional experiments showed overexpression attenuated spheres, while knockdown conferred for cells, as characterized alteration ALDH...
Abstract Purpose It is generally accepted that long noncoding RNAs (lncRNAs) function as vital regulators of tumor development and progression. Long intergenic non‐coding RNA 1410 (LINC01410) a newly discovered lncRNA, its role in osteosarcoma (OS) yet to be determined. Materials methods The expression LINC01410, microRNA‐122‐5p (miR‐122‐5p), N‐myc downstream‐regulated gene 3 (NDRG3) OS tissues was determined using reverse transcription‐quantitative PCR. Interactions between miR‐122‐5p,...
Large language models (LLM) have recently emerged as a powerful tool for variety of natural processing tasks, bringing new surge combining LLM with recommendation systems, termed LLM-based RS. Current approaches generally fall into two main paradigms, the ID direct usage paradigm and translation paradigm, noting their core weakness stems from lacking knowledge uniqueness. To address this limitation, we propose representation, which incorporates pre-trained embeddings LLMs in complementary...