A5041852089- Vestibular and auditory disorders
- Neural Networks and Applications
- Visual perception and processing mechanisms
- Cardiac Arrest and Resuscitation
- Epilepsy research and treatment
- Glaucoma and retinal disorders
- Cognitive Science and Education Research
- Pharmacological Effects and Toxicity Studies
- Traffic and Road Safety
- Ophthalmology and Eye Disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Child and Animal Learning Development
- Injury Epidemiology and Prevention
- Sepsis Diagnosis and Treatment
- Human-Automation Interaction and Safety
- Motor Control and Adaptation
- Pneumocystis jirovecii pneumonia detection and treatment
- Migraine and Headache Studies
- Fuzzy Logic and Control Systems
- Diet and metabolism studies
- Evolutionary Algorithms and Applications
- Neuroscience and Neuropharmacology Research
- Respiratory Support and Mechanisms
- Case Reports on Hematomas
- Natural Language Processing Techniques
University of Basel
1970-2022
University of Tübingen
2019-2020
University Hospital of Basel
2016-2019
Johns Hopkins University
2019
Johns Hopkins Bayview Medical Center
2019
BG Klinik Tübingen
2018-2019
University of California, Davis
2017
Wolfson Medical Center
2015
Tel Aviv University
2015
Heidelberg University
2013-2015
The therapeutic effects of 4-aminopyridine (4AP) were investigated in a randomized, double-blind, crossover trial 10 subjects with familial episodic ataxia nystagmus.After randomization, placebo or 4AP (5 mg 3 times daily) was administered for 2 3-month-long treatment periods separated by 1-month-long washout period. primary outcome measure the number attacks per month; secondary measures attack duration and patient-reported quality life (Vestibular Disorders Activities Daily Living Scale...
Patients with downbeat nystagmus syndrome suffer from oscillopsia, which leads to an unstable visual perception and therefore impaired acuity. The aim of this study was use real-time computer-based feedback compensate for the destabilizing slow phase eye movements.The patients were sitting in front a computer screen head fixed on chin rest. movements recorded by tracking system (EyeSeeCam®). We tested acuity Landolt C (static) during driven condition (dynamic) gaze straight ahead (20°)...
Objective The effects of 4-aminopyridine (4-AP) on downbeat nystagmus (DBN) were analysed in terms slow-phase velocity (SPV), stance, locomotion, visual acuity (VA), patient satisfaction and side using standardised questionnaires. Methods Twenty-seven patients with DBN received 5 mg 4-AP four times a day or placebo for 3 days 10 4 days. Recordings done before the first, 60 min after first last drug administration. Results SPV decreased from 2.42 deg/s at baseline to 1.38 2.03 (p<0.05; post...
To determine the implications of first responses emergency medical services (EMS) to out-of-hospital status epilepticus (SE) on outcome.From 2005 2014, prehospital and in-hospital data were assessed in consecutive adults admitted an academic center with SE. Logistic regression was performed identify variables a robust association between missed epileptic events by EMS no recovery functional baseline survivors.Among 213 SE patients, 150 via EMS. While nonconvulsive (NCSE) 63.7%, convulsive...
Animal experiments have demonstrated that aminopyridines increase Purkinje cell excitability, and in clinical studies, 4-aminopyridine (4-AP) 3,4-diaminopyridine (3,4-DAP) improved downbeat nystagmus. In this double-blind, prospective, crossover study, the effects of equivalent doses 4-AP 3,4-DAP on slow-phase velocity (SPV) nystagmus were compared.Eight patients with due to different etiologies (cerebellar degeneration [n = 1], bilateral vestibulopathy cerebellar Arnold-Chiari I...
Background and purpose The aim was to determine differences of clinical, treatment outcome characteristics between patients with in‐hospital out‐of‐hospital status epilepticus ( SE ). Methods From 2005 2014, clinical data were assessed in adults treated an academic medical care centre. Clinical characteristics, outcomes compared . Results Amongst 352 patients, 213 admitted 139 developed Patients had more acute/fatal aetiologies (60% vs. 35%, P < 0.001), fewer previous seizures (33% 50%, =...
Summary Objective To characterize a critically ill cohort with status epilepticus ( SE ) by the illness severity scoring systems SAPS II (Simplified Acute Physiology Score II), APACHE (Acute and Chronic Health Evaluation SOFA (Sequential Organ Failure Assessment), to compare their performance STESS (Status Epilepticus Severity Score) for outcome prediction. Methods The prospective study was carried out at University Hospital Basel, Swiss tertiary academic medical care center. Consecutive...
The prevention of injury and illness remains an important issue among young elite athletes. Systematic surveillance injuries illnesses during multi-sport events might provide a valuable basis to develop preventive measures, focusing especially on adequate information for youth athletes.To analyse the frequencies characteristics 2015 Winter European Youth Olympic Festival (W-EYOF).All National Committees were asked report daily occurrence or non-occurrence newly sustained standardised...
<h3>Objective</h3> To uncover clinical characteristics leading to false outcome prediction of the Status Epilepticus Severity Score (STESS), a validated and broadly used scoring system for in status epilepticus (SE). <h3>Methods</h3> From 2005 2016, adult patients with SE treated at University Hospital Basel, Switzerland, were included. assess independent associations variables differing between correct death (STESS ≥ 3), multivariable logistic regression models computed using automated...
On the basis of reports by patients with downbeat nystagmus (DBN) that their symptoms were worse during morning but better daytime, we investigated whether intensity DBN changes daytime. was measured at 9 am, 11 and 1 pm. The mean peak slow phase velocity (MPSPV) determined in different eye positions, without fixation, as well three body positions: sitting upright, lying supine nose up, prone down. Twelve either due to cerebellar degeneration or idiopathic etiology examined. major findings...
<h3>Background:</h3> The intensity of downbeat nystagmus (DBN) decreases during the daytime when head is in upright position. <h3>Objective:</h3> This prospective study investigated whether resting different positions (upright, supine, prone) modulates DBN after resting. <h3>Methods:</h3> Eye movements 9 patients with due to cerebellar (n = 2) or unknown etiology 7) were recorded video-oculography. Mean slow-phase velocities (SPV) determined position before at am and then 2 hours (11 am) 4...
BACKGROUND/OBJECTIVES: This study addressed the question whether composition of supposedly 'healthy' or 'unhealthy' dietary regimes has a calorie-independent short-term effect on biomarkers metabolic stress and vascular risk in healthy individuals.SUBJECTS/METHODS: Healthy male volunteers (age 29.5 ± 5.9 years, n = 39) were given standardized baseline diet for two weeks before randomization into three groups different regimes: fast food, Mediterranean German cooking style.Importantly, amount...
A community-based prospective surveillance and case management study of acute respiratory infection (ARI) in children aged 2–60 months age was carried out over a 12-month period Pakata, semi-urban community Ilorin, Kwara State, Nigeria. cohort 481 followed by trained health assistants with thrice weekly home visits to record all symptoms signs ARI, institute treatment based on WHO recommendations. There were three episodes mild, moderate, or severe ARI per child year, including 1.3 pneumonia...
<h3>Background</h3> Patients with bilateral vestibular failure (BVF) suffer from oscillopsia during head movements. This is secondary to the loss of vestibulo-ocular reflex which responsible for stabilising retinal images movements high frequency or velocity. Previous studies documented decreased visual motion sensitivity in such patients at low velocities. The authors now examine coherence tasks, have two advantages: (1) task associated functions middle temporal area; and (2) it affords...
In a series of experiments using the serial reaction time paradigm, authors compared predictions powerful associative model sequence learning (the simple recurrent network; J. L. Elman, 1990) with human performance on problem devised by A. Maskara and W. Noetzel (1993). Even though made network for variants this are often counterintuitive, they matched closely, suggesting that was associatively based rather than rule based. Simple chaining models learning, however, have difficulty in...