A5082201914- RNA and protein synthesis mechanisms
- Protein Structure and Dynamics
- Drug Transport and Resistance Mechanisms
- Antibiotic Resistance in Bacteria
- RNA modifications and cancer
- Advanced Electron Microscopy Techniques and Applications
- Bacterial Genetics and Biotechnology
- Advanced biosensing and bioanalysis techniques
- HIV Research and Treatment
- DNA and Nucleic Acid Chemistry
- Molecular Sensors and Ion Detection
- Cancer-related gene regulation
- Silicon and Solar Cell Technologies
- Semiconductor materials and devices
- Particle accelerators and beam dynamics
- Epigenetics and DNA Methylation
- Cannabis and Cannabinoid Research
Max Planck Institute of Biophysics
2023-2024
Institute of Molecular Biology, Academia Sinica
2015
National Yang Ming Chiao Tung University
2014
Abstract Human feline leukaemia virus subgroup C receptor-related proteins 1 and 2 (FLVCR1 FLVCR2) are members of the major facilitator superfamily . Their dysfunction is linked to several clinical disorders, including PCARP, HSAN Fowler syndrome 2–7 Earlier studies concluded that FLVCR1 may function as a haem exporter 8–12 , whereas FLVCR2 was suggested act importer 13 yet conclusive biochemical detailed molecular evidence remained elusive for both transporters 14–16 Here, we show...
Abstract PmrA, an OmpR/PhoB family response regulator, manages genes for antibiotic resistance. Phosphorylation of regulator induces the formation a symmetric dimer in N-terminal receiver domain (REC), promoting two C-terminal DNA-binding domains (DBDs) to recognize promoter DNA elicit adaptive responses. Recently, determination KdpE–DNA complex structure revealed REC–DBD interface upstream protomer that may be necessary transcription activation. Here, we report 3.2-Å-resolution crystal...
Abstract Heterogeneous nuclear ribonucleoprotein K (hnRNPK) is an RNA/DNA-binding protein involved in chromatin remodeling, RNA processing and the DNA damage response. In addition, increased hnRNPK expression has been associated with tumor development progression. A variety of post-translational modifications have identified shown to regulate function, including phosphorylation, ubiquitination, sumoylation methylation. However, functional significance arginine methylation remains unclear....
In eukaryotes, most secretory and membrane proteins are targeted by an N-terminal signal sequence to the endoplasmic reticulum, where trimeric Sec61 complex serves as protein-conducting channel (PCC). post-translational mode, fully synthesized recognized a specialized additionally containing Sec62, Sec63, Sec71, Sec72 subunits. Recent structures of this Sec in idle state revealed overall architecture pre-opened state. Here, we present cryo-EM structure yeast bound substrate, crystal Sec62...
Abstract Human feline leukemia virus subgroup C receptor-related proteins 1 and 2 (FLVCR1 2) are members of the major facilitator superfamily . Their dysfunction is linked to several clinical disorders, including PCARP, HSAN, Fowler syndrome 2–7 Earlier studies concluded that FLVCR1 may function as a putative heme exporter 8–12 , while FLVCR2 was suggested act importer 13 yet conclusive biochemical detailed molecular evidence remained elusive for both transporters 14–17 Here, we show...