A5019768095- Antibiotic Resistance in Bacteria
- Pharmaceutical and Antibiotic Environmental Impacts
- Mycobacterium research and diagnosis
- Salmonella and Campylobacter epidemiology
- Gut microbiota and health
- Animal Nutrition and Physiology
- Animal Behavior and Welfare Studies
- Animal Disease Management and Epidemiology
- Antimicrobial Resistance in Staphylococcus
- Molecular Biology Techniques and Applications
- Clostridium difficile and Clostridium perfringens research
- Bacteriophages and microbial interactions
- Veterinary medicine and infectious diseases
- Health, Medicine and Society
- Leptospirosis research and findings
- Viral gastroenteritis research and epidemiology
- Food Safety and Hygiene
- Vector-Borne Animal Diseases
- Animal Virus Infections Studies
- Healthcare Systems and Practices
- Escherichia coli research studies
Animal and Plant Health Agency
2018-2023
University of Leeds
2023
The pangenome of Escherichia coli from nearby farms shows how livestock host and local geography shape bacterial populations.
Enterobacterales from livestock are potentially important reservoirs for antimicrobial resistance (AMR) to pass through the food chain humans, thereby increasing AMR burden and affecting our ability tackle infections. In this study 168 isolates four genera of order , primarily Escherichia coli were purified (cattle, pigs sheep) faeces 14 farms in United Kingdom. Their genomes resolved using long- short-read sequencing analyse genes their genetic context, as well explore relationship between...
There are concerns that antimicrobial usage (AMU) is driving an increase in multi-drug resistant (MDR) bacteria so treatment of microbial infections becoming harder humans and animals. The aim this study was to evaluate factors, including usage, affect resistance (AMR) on farm over time.A population 14 cattle, sheep pig farms within a defined area England were sampled three times year collect data AMR faecal Enterobacterales flora; AMU; husbandry or management practices. Ten pooled samples...
F-type plasmids are diverse and of great clinical significance, often carrying genes conferring antimicrobial resistance (AMR) such as extended-spectrum β-lactamases, particularly in Enterobacterales. Organising this plasmid diversity is challenging, current knowledge largely based on from settings. Here, we present a network community analysis large survey environmental (influent, effluent upstream/downstream waterways surrounding wastewater treatment works) livestock We use tractable...
Abstract Salmonella prevalence in UK pigs is amongst the highest Europe, highlighting need to investigate pig farms which have managed maintain a low seroprevalence. A total of 19 that had consistently (<10%) seroprevalence over 4 years (named Platinum farms) were compared against 38 randomly selected Control farms, chosen match same distribution production types and geographical farms. Each farm was visited floor faeces environmental samples collected. It shown significantly higher...
Abstract This study was performed to investigate the occurrence of livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) in batches pigs at slaughter and different stages along line. Nasal ear skin swabs were collected from 105 10 six abattoirs. Cultures (pooled or individual) for MRSA using selective media; presumptive confirmed by mecA nuc gene detection a selection spa -typed. detected 46 batches. All -types those associated with LA-MRSA clonal complex 398. The...
Escherichia coli and other Enterobacteriaceae are highly diverse species with ‘open’ pangenomes 1,2 , where genes move intra- inter-species via horizontal gene transfer 3 . These can cause clinical infections 4,5 as well persist environmentally 6,7 Environmental populations have been suggested important reservoirs of antimicrobial resistance (AMR) genes. However, most analyses focus on isolates 8,9 the pangenome dynamics natural remain understudied, particularly role plasmids. Here, we...
Abstract Campylobacter is a major cause of food poisoning and typically the most common gastroenteritis in UK. Data collected at broiler farm abattoir level, for slaughter batches that were sampled UK‐wide monitoring, used to generate two epidemiological risk factor models. A total 483 slaughtered between January 2016 March 2017 analysis, coming from 19 abattoirs representing more than 85% UK production. For each selected batch, one carcase was after primary chilling 10 randomly birds had...
Abstract IncF plasmids are diverse and of great clinical significance, often carrying genes conferring antimicrobial resistance (AMR) such as extended-spectrum β-lactamases, particularly in Enterobacteriaceae . Organising this plasmid diversity is challenging, current knowledge largely based on from settings. Here, we present a network community analysis large survey environmental (influent, effluent, upstream/downstream waterways surrounding wastewater treatment works) livestock We use...