A5034338817- Blood transfusion and management
- Colorectal Cancer Surgical Treatments
- Hernia repair and management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Blood donation and transfusion practices
- Colorectal Cancer Screening and Detection
- Minimally Invasive Surgical Techniques
- Blood groups and transfusion
- Gastrointestinal disorders and treatments
- Platelet Disorders and Treatments
- Hematopoietic Stem Cell Transplantation
- Colorectal and Anal Carcinomas
- Gastric Cancer Management and Outcomes
- Stoma care and complications
- Cardiac, Anesthesia and Surgical Outcomes
- Anorectal Disease Treatments and Outcomes
- Erythrocyte Function and Pathophysiology
- Colorectal Cancer Treatments and Studies
- Neuroendocrine Tumor Research Advances
- Pelvic floor disorders treatments
- Genetic factors in colorectal cancer
- Diverticular Disease and Complications
- Mast cells and histamine
- Enhanced Recovery After Surgery
- Neutropenia and Cancer Infections
Bispebjerg Hospital
2011-2024
Copenhagen University Hospital
2001-2024
University of Copenhagen
1999-2017
Nordic Lymphoma Group
2015-2016
Sofradir (France)
2015
Capital Region of Denmark
2012
Rigshospitalet
2012
Hvidovre Hospital
1994-2003
Abstract Background The frequency of postoperative infectious complications is significantly increased in patients with colorectal cancer receiving perioperative blood transfusion. It still debated, however, whether transfusion alters the incidence disease recurrence or otherwise affects prognosis. Methods Patient risk variables, variables related to operation technique, and development were recorded prospectively 740 undergoing elective resection for primary cancer. Endpoints overall...
Perioperative blood transfusion and subsequent development of postoperative infectious complications may lead to poor prognosis patients with colorectal cancer. It has been suggested that the be related storage time transfused blood. Therefore, we studied relationship between disease recurrence long-term survival after cancer surgery.Preoperative data were prospectively recorded in 740 undergoing elective resection for primary None received preoperative or chemotherapy radiation therapy....
The correlation between plasma Chromogranin A concentrations and changes in tumor size evaluated by computed tomography (CT) - as a gold standard was evaluated.One hundred sixteen patients with CgA-producing ileo-cecal neuroendocrine tumors were events, which recorded when CT followed another 1 12 months later. Change defined regression, progression, or stable disease using RECIST criteria 1.1. Of 426 there 97 279 disease, 50 regression. Based on the ROC curves cutoff value of 25% change...
BACKGROUND: Blood transfusion may reduce survival after curative surgery for solid tumors. This be related to extracellular content of cancer growth factors present in components. Vascular endothelial factor (VEGF) is a potent stimulator angiogenesis The potential VEGF various blood components was evaluated. STUDY DESIGN AND METHODS: Soluble (sVEGF, isotype 165) determined by an enzyme‐linked immunosorbent assay (EIA) serum and plasma samples lysed cells from healthy volunteers....
LBA3514 Background: Organ preserving treatment strategies based on chemoradiotherapy may spare rectal cancer patients of major surgery and stoma. We suggest substantially improved tumor control by increasing the radiotherapy dose, without significant increase in rate late effects. designed a prospective phase II trial to test high-dose low for organ preservation multicenter setting. Methods: enrolled with localized T1-3 N0-1 M0 within 6 cm from anal verge performance status 0-2. Any N1-nodes...
Summary Twelve patients had their arterial oxygen saturation measured pre‐operatively and on days 1, 4 7 after laparotomy. Measurements were performed in the supine, sitting standing positions each day. Arterial was significantly higher during 1 operation compared with supine position (p < 0.05). These results give further evidence for benefits of patient mobilisation major surgery.
Abstract Objectives: TNF‐α and IL‐2 are important cytokines in macrophage T‐lymphocyte activity against infection dissemination of malignant cells. We studied the influence supernatants from stored whole blood buffy‐coat‐depleted SAGM (saline, adenine, glucose mannitol) stimulating release an ex vivo assay. Methods: Supernatants 10 units were collected after 1, 21 35 days standard bank storage. Heparinized 20 healthy volunteers (as ‘recipients’), corresponding ABO Rh type to blood, used a...
We studied extracellular accumulation in buffy‐coat‐derived platelet pools suspended additive solutions (PAS). 20 were prepared from buffy coats of 60 donors and stored either PAS I ( n = 10) or II 10). Samples drawn the to determine normal range histamine, plasminogen activator inhibitor 1 (PAI‐1), myeloperoxidase (MPO) interleukin (IL)‐6. After preparation samples collected on days 0, 5 7 respectively, same substances. Extracellular PAI‐1 MPO detected significant levels P < 0.0001)...
Background and Objectives Poor prognosis after resection of primary colorectal cancer may be related to the combination perioperative blood transfusion subsequent development infectious complications. White cell‐ platelet‐derived growth substances, including vascular endothelial factor (VEGF), involved in this process. Therefore, we studied vitro release VEGF from white cells platelets stimulated by bacterial antigens supernatants stored red cell components. Materials Methods Eight units...
Abstract Background Side effects of platelet transfusion may be associated with infusion bioactive substances. We therefore studied extracellular accumulation histamine, plasminogen activator inhibitor (PAI)‐1, vascular endothelial growth factor (VEGF), and interleukin (IL)‐6 during preparation storage various concentrates. Methods Twenty buffy‐coat‐derived pools (BCPC) were prepared stored in additive solutions (PAS). Twelve apheresis (APC) units using the COBE Spectra LRS, 14 Fenwal Amicus...
Abstract Objectives A recent study showed less bleeding and need of transfusion after total mesorectal excision (TME) compared with conventional rectal cancer surgery. The aim this was to evaluate result in more details. Patients methods Comparison history resections two different multicentre‐studies. Two hundred forty‐six patients were operated the period 1991–93 a technique 311 TME‐technique 1996–98. Peri‐operative data, including blood from one month before until operation, recorded...
Leucocyte filtration has been suggested to improve transfusion products. We studied the effect of prestorage versus bedside leucofiltration on reduction bioactive substances and leucocyte content in donor blood. Forty‐five units whole blood from healthy donors were studied. Of these units, 9 stored under standard conditions for 35 d, leucofiltered after donation then 3×9 7, 21 respectively, before leucofiltration. Samples collected immediately donation, leucofiltration, analysed by ELISA RIA...
Single incision laparoscopic surgery (SILS) may be even less invasive to a patient than conventional (CLS).of the applicability of procedure, first 1½ year experiences and comparison with CLS for colonic cancer resections.Since November 2010 SILS procedures was trained by two surgeons. Data prospectively registered. Each all resections blindly matched patients operated within period from 2009-2011 respect gender, T stadium, age, ASA score BMI. In routine accelerated "fast track" program use...