A5051976624- CRISPR and Genetic Engineering
- Viral Infectious Diseases and Gene Expression in Insects
- PI3K/AKT/mTOR signaling in cancer
- Polyamine Metabolism and Applications
- Transgenic Plants and Applications
- Mast cells and histamine
- Monoclonal and Polyclonal Antibodies Research
- Virus-based gene therapy research
- Protein purification and stability
- Histone Deacetylase Inhibitors Research
South Australian Health and Medical Research Institute
2020-2021
The University of Adelaide
2020-2021
Abstract The mechanistic target of rapamycin complex 1 (mTORC1) is an important regulator cellular metabolism that commonly hyperactivated in cancer. Recent cancer genome screens have identified multiple mutations Ras-homolog enriched brain (Rheb), the primary activator mTORC1, might act as driver oncogenes by causing hyperactivation mTORC1. Here, we show a number recurrently occurring Rheb mutants drive hyperactive mTORC1 signalling through differing levels insensitivity to inactivator...
Monoclonal antibodies (mAbs) are high value agents used for disease therapy ("biologic drugs") or as diagnostic tools which widely in the healthcare sector. They generally manufactured mammalian cells, particular Chinese hamster ovary (CHO) cells cultured defined media, and harvested from medium. Rheb is a small GTPase which, when bound to GTP, activates mechanistic target of rapamycin complex 1, protein kinase that drives anabolic processes including synthesis ribosome biogenesis. Here, we...
Monoclonal antibodies are high value agents used for disease therapy (‘biologic drugs’) or as diagnostic tools which widely in the health care sector. They generally manufactured mammalian cells, particular Chinese hamster ovary (CHO) cells cultured defined media, and harvested from medium. Rheb is a small GTPase which, when bound to GTP, activates mechanistic target of rapamycin complex 1 (mTORC1), protein kinase that drives anabolic processes including synthesis ribosome biogenesis. Here...