A5016341000- Transplantation: Methods and Outcomes
- RNA Interference and Gene Delivery
- T-cell and B-cell Immunology
- Peptidase Inhibition and Analysis
- Aortic aneurysm repair treatments
- Cell Adhesion Molecules Research
- Peripheral Artery Disease Management
- Renal Transplantation Outcomes and Treatments
- Immunotherapy and Immune Responses
- Organ Transplantation Techniques and Outcomes
- Neuropeptides and Animal Physiology
- Immune Cell Function and Interaction
- Cerebrovascular and Carotid Artery Diseases
- Immune Response and Inflammation
- Renal and Vascular Pathologies
- Signaling Pathways in Disease
- Cardiac, Anesthesia and Surgical Outcomes
- Viral Infections and Immunology Research
- Cytomegalovirus and herpesvirus research
- Adenosine and Purinergic Signaling
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiac Valve Diseases and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Organ and Tissue Transplantation Research
- RNA Research and Splicing
University Hospital of Zurich
2021-2024
University of Zurich
2023-2024
Klinikum rechts der Isar
2012-2023
Technical University of Munich
2014-2020
Universitätsklinikum Gießen und Marburg
2002-2010
Giessen School of Theology
2004-2009
Justus-Liebig-Universität Gießen
1998-2008
USC Norris Comprehensive Cancer Center
2003
University of Southern California
2003
Brigham and Women's Hospital
1997-2000
Background: Atrial fibrillation (AF) is a common complication after coronary artery bypass grafting operation (CABG). Experimental data have shown antiarrhythmic effects of n-3 polyunsaturated fatty acids (PUFA) on myocardial cells. Orally administered PUFA could significantly reduce the rate postoperative AF. We assessed efficacy for prevention AF CABG. were given intravenously to prevent variation in bioavailability.
The CD26 antigen, one of the major costimulatory molecules in T cell activation, was shown to possess dipeptidyl peptidase IV (DPP IV) activity. Previously, we demonstrated that immunosuppressed kidney transplant patients exhibit lower DPP serum activity as compared with healthy individuals. In present study, analyzed role CD26/DPP immune cascade triggered by organ transplantation and leading acute rejection cardiac allografts rat recipients. Transplantation hearts from (Lewis x Brown...
Collecting biological tissue samples in a biobank grants unique opportunity to validate diagnostic and therapeutic strategies for translational clinical research. In the present work, we provide our long-standing experience establishing maintaining of vascular samples, including evaluation quality, especially formalin-fixed paraffin-embedded specimens (FFPE). Our Munich Vascular Biobank includes, thus far, biomaterial from patients with high-grade carotid artery stenosis (n = 1567),...
Objective: Acute myocardial rejection is a cell-mediated process characterized by increased leukocyte recruitment into the graft tissue. Transcription factors like STAT-1 and AP-1 are critically involved in this regulating vascular adhesion molecule expression. The aim of our study was to investigate effect decoy oligodeoxynucleotide (dODN) treatment targeting transcription on acute cardiac allograft rat transplant model.
Abstract We tested the effects of blocking CD28-B7 T cell costimulation by using CTLA4Ig in an established transplantation model which LBNF1 cardiac allografts are rejected accelerated manner (<36 h) LEW rats presensitized with Brown-Norway skin grafts. Treatment or without donor alloantigen sensitization phase (between and engraftment) minimally delayed rejection. However, adjunctive infusion effector (after resulted long term graft survival donor-specific tolerance 30 to 50%...
AimsCardiac allograft vasculopathy (CAV) continues to be an unsolved clinical problem requiring the development of new therapeutic strategies. We have previously demonstrated that ex vivo donor treatment with decoy oligodeoxynucleotides (ODN) targeting transcription factors, activator protein-1 (AP-1) or signal transducer and transcription-1 (STAT-1), delays acute rejection prolongs cardiac survival. Here, we investigated whether this regime also prevents occurrence CAV in a fully allogeneic...
Background. Brain death has been identified as an independent risk factor for chronic allograft dysfunction. In two retrospective clinical studies, we showed that dopamine treatment of brain-dead donors improves long-term kidney graft survival. The mechanisms underlying the protective effects in vivo have not identified. To elucidate effect on kidneys donors, studied a model brain rats. Methods. F344 rats, was induced by epidural inflation 3F Fogarty catheter. Apneic animals were...
Aims ADAMTS family of metalloproteases (a disintegrin and metalloprotease with thrombospondin motifs) possesses high proteolytic activity especially regarding proteoglycans. Their expression pattern in carotid plaques is as-yet unknown. The aim the study was therefore analysis ADAMTS1, 4, 5, 13 their inhibitors TIMP-1 TIMP-3 stable unstable plaques. Methods Atherosclerotic were collected from 40 patients (29 men, 11 women, mean age 70 years) undergoing endarterectomy. specimens categorized...
Objectives The aim of this study was to compare the contrast-to-noise ratio (CNR) values infarct and remote myocardium as well blood after application 0.1 mmol/kg gadobutrol gadobenate dimeglumine on late gadolinium enhancement magnetic resonance (MR) images. Material Methods a prospective randomized controlled clinical study. After informed consent obtained, 20 patients (12 men, 8 women; mean age, 67 ± 11 years) with known chronic myocardial infarction were included for an intraindividual...
Sanglifehrin A (SFA) is a novel compound with unsurpassed cyclophilin-binding affinity, but relatively low direct antilymphocytic activity. Here, we report the capacity of SFA to selectively inhibit key dendritic cell (DC) functions in vivo and suppress acute chronic heart allograft rejection. We show that vivo, profoundly decreases DC receptor-mediated endocytosis macropinocytosis DC-T-cell allostimulatory Furthermore, abrogates >90% IL-12p70 production while having no significant effect on...
In this study, we investigated whether hydration with sodium bicarbonate is superior to saline in addition theophylline (both groups) the prophylaxis of contrast-induced nephropathy (CIN). It was a prospective, randomized, double-blinded study university hospital on 2 general intensive care units (63% investigations) and normal wards.After approval local ethics committee informed consent 152 patients screening serum creatinine ≥1.1 mg/dL and/or at least 1 additional risk factor for CIN...
Blocking CD28-B7 T cell costimulatory activation by the fusion protein CTLA4Ig prevents rejection and induces long-term graft acceptance in various experimental transplant models. There are reported differences efficacy of renal cardiac rodent allograft models, but it is not clear whether these due to strain or species investigated different studies reported. This study investigates effect blocking costimulation with murine rat models acute using same complete major histocompatibility...
Metalloproteases with a disintegrin domain (ADAM) has already been implicated in various cellular processes such as cytokine and growth factor shedding, proliferation, migration, degradation of extracellular matrix. Their role the development progression atherosclerosis carotid lesions is however unknown. The aim study was to analyze expression proteolytic ADAMs (8, 9, 10, 12, 15, 17) their inhibitors TIMP-1, -3 patients high-graded artery stenosis. Atherosclerotic plaques were obtained from...
Quantitative measurement of specific mRNA species is major importance for approaching many fundamental questions in biology. Until now, quantitation gene expression has usually been done by Northern blotting, but this procedure relatively insensitive, requiring microgram amounts RNA. Furthermore, unless linear ranges RNA concentration are determined, the semiquantitative at best. Because limitations various strategies have developed cDNA polymerase chain reaction (PCR)-based methods (1-3),...
Acute lower limb ischemia (ALI) is a common vascular emergency, requiring urgent revascularization by open or endovascular means. The aim of this retrospective study was to evaluate patient demographics, treatment and periprocedural variables affecting the outcome in ALI patients consecutive cohort tertiary referral center. Primary events (POE) were 30-day (safety) 180-day (efficacy) combined mortality major amputation rates, respectively. Secondary outcomes perioperative medical surgical...
Single-center retrospective cohort study to evaluate the impact of oral anticoagulation (OAC) on long-term outcomes conservatively managed acute type B aortic dissection.Clinical and morphological data eligible patients from a high-volume vascular centre 1 January 2003 through 31 December 2020 were evaluated. Patients excluded for: A or non-A-non-B dissection, isolated abdominal intramural haematoma connective tissue disease. The primary outcome was freedom late events (intervention, rupture...