A5102998281- Epigenetics and DNA Methylation
- Bacterial Genetics and Biotechnology
- Cancer Genomics and Diagnostics
- Protist diversity and phylogeny
- Bacteriophages and microbial interactions
- Genomics and Chromatin Dynamics
- DNA and Nucleic Acid Chemistry
- Genetics, Bioinformatics, and Biomedical Research
- Genomics and Phylogenetic Studies
- Technology Adoption and User Behaviour
- Protein Structure and Dynamics
- Phosphorus compounds and reactions
- Histone Deacetylase Inhibitors Research
- Organic Chemistry Cycloaddition Reactions
- Cancer-related gene regulation
- Gene Regulatory Network Analysis
- Computational Drug Discovery Methods
- Pancreatic and Hepatic Oncology Research
- Digital Platforms and Economics
- FinTech, Crowdfunding, Digital Finance
- RNA and protein synthesis mechanisms
- Inorganic and Organometallic Chemistry
- Environmental DNA in Biodiversity Studies
- Bioinformatics and Genomic Networks
Boğaziçi University
2013-2025
University of California, Los Angeles
2021-2024
UCLA Health
2020-2022
Michigan State University
2014-2018
Abstract Early cancer detection by cell-free DNA faces multiple challenges: low fraction of tumor DNA, molecular heterogeneity cancer, and sample sizes that are not sufficient to reflect diverse patient populations. Here, we develop a approach address these challenges. It consists an assay, cfMethyl-Seq, for cost-effective sequencing the methylome (with > 12-fold enrichment over whole genome bisulfite in CpG islands), computational method extract methylation information diagnose patients....
Digitalisation has significantly increased cybersecurity risks in organisations, notably for small to medium-sized enterprises (SMEs), which IT departments often have relatively teams and limited resources. Cyber insurance enables SMEs navigate more economically, providing an essential risk transfer alternative costly reduction strategies. This article examines the antecedents, emergence, application of cyber as a solution concerns against backdrop increasing digitalisation. The research...
High-resolution three-dimensional models of Caulobacter crescentus nucleoid structures were generated via a multi-scale modeling protocol. Models built as plectonemically supercoiled circular DNA and by incorporating chromosome conformation capture based data to generate an ensemble base pair resolution consistent with the experimental data. Significant structural variability was found different degrees bending twisting but overall similar topologies shapes that are C. cell dimensions. The...
Chromatin modifications are epigenetic regulatory features with major roles in various cellular events, yet they remain understudied algae. We interrogated the genome-wide distribution pattern of mono- and trimethylated histone H3 lysine 4 (H3K4) using chromatin-immunoprecipitation followed by deep-sequencing (ChIP-seq) during key phases Chlamydomonas cell cycle: early G1 phase, Zeitgeber Time 1 (ZT1), when cells initiate biomass accumulation, S/M phase (ZT13) replicating DNA undergoing...
Cellular environments are highly crowded with biological macromolecules resulting in frequent non-specific interactions. While the effect of such crowding on protein structure and dynamics has been studied extensively, very little is known how cellular affects conformational sampling nucleic acids. The preferences DNA (deoxyribonucleic acid) described from fully atomistic molecular simulations systems containing a dodecamer surrounded by crowders. From simulations, it was found that...
Abstract Early cancer detection by cell-free DNA (cfDNA) faces multiple challenges: the low fraction of tumor in cfDNA, molecular heterogeneity cancer, and sample sizes that are too small to reflect heterogeneous patient population. We have developed an integrated system, CancerRadar, addresses all three challenges. It consists (1) a cost-effective experimental assay, cfMethyl-Seq, for genome-wide methylation profiling which provides >12-fold enrichment over Whole Genome Bisulfite...
1H NMR spectra of epoxy-fused cyclopentane derivatives have been computationally investigated with density functional calculations in order to unravel the shielding effect epoxy ring on chemical shifts N-substituted cyclopentane-3, 5-diol derivatives. Both and spin–spin coupling constants calculated WP04/cc-pVTZ level theory solution. The WP04/cc-pVTZ// B3LYP/6-31+G(d) methodology has found reproduce best experimental results This study is expected lead experimentalists their endeavour...
ABSTRACT Chromatin modifications are key epigenetic regulatory features with roles in various cellular events, yet histone mark identification, gene wide distribution and relationship to expression remains understudied green algae. Histone lysine methylation is regarded as an active chromatin many organisms, implicated mediating euchromatin. We interrogated the genome pattern of mono- trimethylated H3K4 using Chromatin-Immunoprecipitation followed by deep-sequencing (ChIP-Seq) during phases...