A5073312749- Breast Implant and Reconstruction
- Reconstructive Surgery and Microvascular Techniques
- Autophagy in Disease and Therapy
- Hepatitis C virus research
- Epigenetics and DNA Methylation
- Microplastics and Plastic Pollution
- HIV/AIDS drug development and treatment
- Breast Cancer Treatment Studies
- Healthcare and Environmental Waste Management
- Cancer Genomics and Diagnostics
- Cellular transport and secretion
- Ubiquitin and proteasome pathways
- SARS-CoV-2 detection and testing
- Cancer, Hypoxia, and Metabolism
- Advanced Fluorescence Microscopy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Cancer survivorship and care
- Hepatitis B Virus Studies
- Environmental DNA in Biodiversity Studies
- Nanoparticle-Based Drug Delivery
- Microbial Community Ecology and Physiology
- Medical Image Segmentation Techniques
- Infection Control and Ventilation
- RNA Interference and Gene Delivery
- Photoacoustic and Ultrasonic Imaging
Tianjin Medical University Cancer Institute and Hospital
2016-2025
Sichuan University
2018-2025
Xiamen University
2024
Wannan Medical College
2024
University of California, Los Angeles
2021-2024
Zhejiang Sci-Tech University
2024
Xi'an Jiaotong University
2020-2023
Jilin University
2022
Chongqing University of Posts and Telecommunications
2016-2022
Ten Chen Hospital
2022
Hepatitis C virus (HCV) infection affects an estimated 185 million people worldwide, with chronic often leading to liver cirrhosis and hepatocellular carcinoma. Although HCV is curable, there unmet need for the development of effective affordable treatment options. Through a cell-based high-throughput screen, we identified chlorcyclizine HCl (CCZ), over-the-counter drug allergy symptoms, as potent inhibitor infection. CCZ inhibited in human hepatoma cells primary hepatocytes. The mode action...
Abstract Early cancer detection by cell-free DNA faces multiple challenges: low fraction of tumor DNA, molecular heterogeneity cancer, and sample sizes that are not sufficient to reflect diverse patient populations. Here, we develop a approach address these challenges. It consists an assay, cfMethyl-Seq, for cost-effective sequencing the methylome (with > 12-fold enrichment over whole genome bisulfite in CpG islands), computational method extract methylation information diagnose patients....
Abstract Autophagy-related factors are implicated in metabolic adaptation and cancer metastasis. However, the role of autophagy progression their effect treatment response remain largely elusive. Recent studies have shown that UVRAG, a key autophagic tumour suppressor, is mutated common human cancers. Here we demonstrate cancer-related UVRAG frameshift (FS), which does not result null mutation, expressed as truncated FS colorectal (CRC) with microsatellite instability (MSI), promotes...
Chronic kidney disease (CKD) ultimately causes renal fibrosis and end-stage disease, thus seriously threatens human health. However, current medications for CKD are inefficient, which is often due to poor targeting capability tubule. In this study, we discover that biomimetic high-density lipoprotein (bHDL) lipid nanoparticles possess excellent ability injured tubular epithelial cells by injury molecule-1(KIM-1) mediated internalization. Thus, co-load anti-inflammatory drug triptolide (TP)...
Three-dimensional (3D) image technology in breast measurement requires exploration. We aimed to evaluate a new automatic system based on artificial intelligence (AI). This prospective controlled study included all-women patients who underwent reconstruction from January May 2022. Patients 3D scanning before reconstruction. Two doctors performed the measurements twice through AI and manual images, respectively. The results of bilateral width, convexity, height, volume, time were recorded....
Significance Skin pigmentation provides first-line protection against UV radiation (UVR) that increases the risk of skin cancers. However, mechanisms underlying this process remain poorly understood. Here, we identified autophagic tumor suppressor UVRAG as a bona fide player in melanosome biogenesis by targeting lysosome-related organelles complex 1 (BLOC-1) independently autophagy. maintains localization and stability BLOC-1 to facilitate sorting/delivery melanogenic cargoes. Reduced levels...
Significance Negative-strand RNA viruses are highly pathogenic and cause many severe diseases in humans animals. These generally use existing cellular pathways to enter cells, which involves intensive interaction with the endomembrane network, offering endocytic pathway as an attractive scheme for therapeutic intervention. Molecular mechanisms governing virus entry remain incompletely understood. We found that UV-radiation resistance-associated gene, well known regulating autophagy...
Prostate cancer, one of the leading causes disease and death in men all over world, is challenging to treat. α-Enolase, a multifunctional protein, overexpressed on human prostate carcinoma cells, thereby it potential target for treatment cancer. In current study, pHCT74 peptide was used construct kind highly targeted liposome (pHCT74-lipo) loaded with doxorubicin (pHCT74-lipo-Dox), which specifically α-enolase tumour cells. Compared liposomes without modification, pHCT74-lipo-Dox displayed...
Recently, we reported that chlorcyclizine (CCZ, Rac-2), an over-the-counter antihistamine piperazine drug, possesses in vitro and vivo activity against hepatitis C virus. Here, describe structure-activity relationship (SAR) efforts resulted the optimization of novel derivatives as anti-HCV agents. Several compounds exhibited EC50 values below 10 nM HCV infection, cytotoxicity selectivity indices above 2000, showed improved pharmacokinetic properties. The optimized molecules can serve lead...
Purpose There is an ongoing debate on the optimal sequence of radiation and breast reconstruction. The purpose this article was to (a) assess impact autologous reconstruction (b) analyze best timing for in setting a Chinese population. Methods A retrospective review patients undergoing with lower abdominal flaps between 2001 2014 Tianjin Medical University Cancer Hospital performed. Patients were grouped by their irradiation status (irradiated vs nonirradiated). irradiated group further...
Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance and a progressive loss in mass function of pancreatic β-cells. In T2DM, lipotoxicity leads to β-cells dysfunction decreases its number. Autophagy serves crucial role maintaining the normal islet architecture Moreover, glucagon-like peptide-1 (GLP-1) analogs have beneficial roles However, protective effects GLP-1 agents on palmitate (PA)-induced their underlying mechanisms are not fully elucidated. Forkhead box O1 (FoxO1)...
Direct-acting antivirals (DAAs) have greatly improved the treatment of HCV infection. To improve response and prevent resistance, combination regimens been focus clinical development. Regimens are often first assessed in vitro, with most studies to date using subgenomic replicon systems, which do not replicate complete life cycle preclude study entry assembly inhibitors. Infectious full-length systems developed being used test drug efficacy.Using cell-based Con1b an infectious (HCVcc-Luc)...
Developing the natural medicine that allow for specific targeting cytotoxicity is a very important research area in development of anti-tumor drugs.This study was conducted to determine targeted inhibitory effects luteolin-loaded Her-2-poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) on gastric cancer cells and delineate mechanism underlying inhibition tumors by luteolin.Luteolin-loaded Her-2-PLGA NPs (Her-2-NPs) were prepared, physically chemically characterized, their...