A5101592092- Fungal Biology and Applications
- DNA and Nucleic Acid Chemistry
- RNA and protein synthesis mechanisms
- Plant Molecular Biology Research
- Microbial Natural Products and Biosynthesis
- Advanced biosensing and bioanalysis techniques
- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Plant Gene Expression Analysis
- Phytochemistry and Biological Activities
- Receptor Mechanisms and Signaling
- Plant tissue culture and regeneration
- Chemical synthesis and alkaloids
- Plant Pathogens and Fungal Diseases
- Plant Stress Responses and Tolerance
- Cancer-related Molecular Pathways
- Natural product bioactivities and synthesis
- Plant biochemistry and biosynthesis
- CRISPR and Genetic Engineering
- Food Quality and Safety Studies
- Insect Pheromone Research and Control
- Insect and Arachnid Ecology and Behavior
- Tannin, Tannase and Anticancer Activities
- Genomics, phytochemicals, and oxidative stress
- Light effects on plants
Beijing Normal University
2024
Jilin Agricultural University
2023
Beijing Forestry University
2021-2023
East China Normal University
2023
Jiangsu University of Science and Technology
2023
Hebei University
2011-2020
Nanjing Agricultural University
2020
Tsinghua University
2018
University of Montana
2013
Arizona State University
2007-2013
NMDA (N-methyl-D-aspartate) receptors are excitatory neurotransmitter in the brain critical for synaptic plasticity and neuronal development. These Ca2+-permeable glutamate-gated ion channels whose physiological properties regulated by intracellular Ca2+. We report here purification of a 20 kDa protein identified as calmodulin that interacts with NR1 subunit receptor. Calmodulin binding to is Ca2+ dependent occurs homomeric complexes, heteromeric NR1/NR2 from brain. Furthermore, causes...
Ca2+ influx through N-methyl-D-aspartate (NMDA) receptors activates signal transduction pathways critical for many forms of synaptic plasticity in the brain. NMDA receptor-mediated also downregulates gating channels a process called Ca2+-dependent inactivation (CDI). Recent studies have demonstrated that calcium binding protein calmodulin directly interacts with receptors, suggesting may play role CDI. We report here mutation specific site CO region NR1 subunit receptor blocks Moreover,...
MYB transcription factor (TF) is one of the largest superfamilies that play a vital role in multiple plant biological processes. However, family has not been comprehensively identified and functionally verified Cajanus cajan, which sixth most important legume crop. Here, 170 CcR2R3-MYBs were divided into 43 functional subgroups. Segmental tandem duplications alternative splicing events found promoted expansion CcR2R3-MYB gene family. Functional prediction results showed mainly involved...
Plant leucine-rich repeat (LRR) receptor-like kinases (RLKs) and LRR proteins (RLPs) comprise a large family of cell surface receptors that play critical roles in signal perception transduction. Both LRR-RLKs LRR-RLPs rely on regulatory to initiate downstream signaling pathways. BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED KINASE 1/SOMATIC EMBRYOGENESIS RECEPTOR 3 (BAK1/SERK3) SUPPRESSOR OF BIR1-1 (SOBIR1) are important extensively studied with distinct functions. Although the mechanism BAK1...
Four new eudesmanes, namely, 4(15)-eudesmene-1beta,7alpha-diol (1), 4(15)-eudesmene-1beta,7beta-diol (2), 7-trinoreudesma-4(15),8-dien-1beta-ol-7-one (3), and eudesma-4(15),7-dien-1beta-ol (4), as well three known compounds, 5-epi-eudesma-4(15)-ene-1beta,6beta-diol (5), 4(15)-eudesmene-1beta,6alpha-diol (6), 4(15)-eudesmene-1beta,5alpha-diol (7), were isolated from the aerial part of Caragana intermedia. The structures elucidated by spectroscopic spectrometric analyses including 1D, 2D NMR,...
Dihydroberkleasmin A (1), a new ester-substituted sesquiterpenoid related to the eremophilane class, together with known compound berkleasmin C (2), were isolated from fermentation broth of plant endophytic fungus Pestalotiopsis photiniae. The structure dihydroberkleasmin (1) was elucidated by extensive spectroscopic analysis. stereochemistry assigned comparison NMR data those A.
Abstract This unit describes the preparation of dimethoxytrityl (DMTr)−protected α‐ L ‐threofuranosyl nucleic acid (TNA) phosphoramidite monomers for A, C, G, T, and diaminopurine, as well their incorporation into TNA oligonucleotides by solid‐phase synthesis. Starting from commercially available ‐ascorbic acid, protected threofuranosyl sugar is obtained in four steps. Vorbrüggen‐Hilbert‐Johnson glycosylation affords desired nucleosides, which are converted to corresponding DMTr‐protected...
Abstract Synthetic nucleic acid analogues have profoundly advanced our knowledge of DNA and RNA, as well the complex biological processes that involve acids. As a pivotal enzyme, eukaryotic RNA polymerase II (Pol II) is responsible for transcribing into messenger which then serves template to direct protein synthesis. Chemically modified greatly facilitated structural elucidation Pol elongation understanding key chemical interactions governing transcriptional fidelity. This review addresses...
Abstract Two new sesquiterpenoid esters, pestalotiopins B and C ( 1 2 , resp.) related to the eremophilane class, together with one known compound, berkleasmin 3 ), were isolated from fermentation broth of plant endophytic fungus Pestalotiopsis photiniae. Their structures relative configurations elucidated by extensive spectroscopic analysis including 1D‐ 2D‐NMR (HSQC, HMBC, NOESY), MS experiments. Compound has an interesting lactam structure, this type a structure is reported for first time.
Abstract Microneme protein 2 (MIC2) and MIC2-associated (M2AP) play crucial roles in the gliding motility host cell invasion of Toxoplasma gondii . Complex formation between MIC2 M2AP is required for maturation transport from microneme to parasite surface. Previous studies showed that associates with 6 th TSR domain (TSR6), but detailed interaction remains unclear. In this study, we report crystal structures alone complex TSR6. domains have an unusually thin, long structure a layer...
A new spirocyclic compound named (2S, 5S, 7S)-3α-hydroxyl-exogonic acid (1) was isolated from the liquid culture of entomogenous fungus Isaria cateniannulata. The structure and relative stereochemistry 1 were elucidated by extensive spectroscopic analysis comparison its NMR data with those known compound. Compound showed weak inhibitory activity against HeLa IC50 value 80.5 μg ml− 1.