A series of fifteen silver (I) quinoline complexes Q1–Q15 have been synthesized and studied for their biological activities. were from the reactions quinolinyl Schiff base derivatives L1–L5 (obtained by condensing 2-quinolinecarboxaldehyde with various aniline derivatives) AgNO3, AgClO4 AgCF3SO3. characterized spectroscopic techniques structures [Ag(L1)2]NO3Q1, [Ag(L1)2]ClO4Q6, [Ag(L2)2]ClO4Q7, [Ag(L2)2]CF3SO3Q12 [Ag(L4)2]CF3SO3Q14 unequivocally determined single crystal X-ray diffraction...

This study assessed the cardioprotective effects of <1 kDa peptide fractions from neem seed protein hydrolysates (NSPHs) in cardiac tissues ex vivo. Oxidative injury was induced male Wister rats by incubating with 0.1 mM FeSO4 (pro-oxidant) for 30 minutes. Untreated lacked fractions, while normal control and pro-oxidant. Treatment peptides increased activities/levels catalase, superoxide dismutase, ENTPDase, 5'NTPDase, glutathione, HDL-cholesterol. Conversely, levels/activities...

Cardiovascular abnormalities have been reported as a major contributor of diabetic mortality. The protective effect ferulic acid on cardiomyopathy in fructose-streptozotocin induced type 2 diabetes (T2D) rat model was elucidated this study. Type rats were treated by oral administration low (150 mg/kg b.w) and high (300 doses acid. Metformin used the antidiabetic drug. Rats humanely euthanized after 5 weeks treatment, their blood hearts collected. Induction T2D depleted levels reduced...

The antidiabetic potential of caffeic acid in fructose/streptozotocin-induced type 2 diabetic rats was examined this study.Male Sprague-Dawley were supplied with 10% fructose solution for 14 days followed by an intraperitoneal injection 40 mg/kg bw streptozotocin to induce diabetes (T2D). Rats treated both low (150 bw) and high (300 doses 5 weeks, while the positive control group metformin (200 bw).Treatment significantly decreased blood glucose levels elevated serum insulin improving...

Xylitol and erythritol have been reported in numerous previous recent studies as potential antidiabetic sweeteners, however, it is not certain which one most effective this regard. In the present study, effects of xylitol were comparatively investigated on blood glucose, insulin level, dyslipidemia, pancreatic islet morphology β-cell function, redox imbalance a type 2 diabetes (T2D) model rats. Seven-week-old male Sprague-Dawley rats randomly divided into 8 groups: Normal Control (NC),...

Oxidative stress is a primary culprit in the pathophysiology of infertility conditions males. This study investigated effects Ocimum tenuiflorum on redox imbalance, cholinergic and purinergic dysfunctions glucose dysmetabolism oxidative-mediated testicular toxicity using vitro, ex vivo silico models. Induction oxidative injury was carried out by incubating normal tissue with 0.1 mM FeSO4 treated co-incubating different concentrations O. infusion for 30 min at 37°C. displayed significant...

There are increasing concerns on the rising cases of diabetes mellitus with type 2 (T2D) being major interest as well cost its treatment. Plant phenolic compounds natural and potent antioxidants that have been widely reported for their antidiabetic activities properties, one which is ferulic acid. The effect acid (FA) diabetogenic pancreatic architecture linked to T2D was investigated in rats. induced male Sprague-Dawley rats using fructose-streptozotocin model. Diabetic were treated FA at...

The ability of umbelliferone to stimulate muscle glucose uptake and its effect on fatty acid metabolism as well nucleotide hydrolysis cholinergic activity were investigated in isolated psoas muscles. Incubation with muscles led increase uptake, elevated GSH, SOD catalase activities, depleted malondialdehyde nitric oxide levels. It also decrease ATPase concomitant ENTPDase 5′nucleotidiase activities. activities chymotrypsin acetylcholinesterase, glycogen phosphorylase, glucose-6-phosphatase,...

This present study investigated the antioxidative and antidiabetic properties of kolaviron by analysing its inhibitory effect on key metabolic activities linked to T2D, in vitro ex vivo. Kolaviron significantly inhibited α-glucosidase α-amylase activities, intestinal glucose absorption dose-dependently, while promoting muscle uptake. Induction oxidative pancreatic injury depleted glutathione level, superoxide dismutase, catalase, ATPase elevating malondialdehyde nitric oxide levels,...

The antidiabetic properties of ferulic acid and its protective role against Fe2+-induced oxidative pancreatic injury were investigated in this study using vitro ex vivo models. Induction the pancreas was achieved by incubating normal tissue with 0.1 mM FeSO4 treated co-incubating different concentrations for 30 min at 37°C. Ferulic inhibited activities α-glucosidase, α-amylase, lipase significantly (p < .05) promoted glucose uptake isolated rat psoas muscles. caused significant depletion...

Natural products-based antioxidants have been well reported for their therapeutic benefits in the treatment and management of neurodegenerative diseases. The neuroprotective effect ursolic acid (UA) against oxidative injury was investigated isolated rat brain. Induction brains with 0.1 mM FeSO4 led to depleted levels glutathione, superoxide dismutase, catalase, ENTPDase activities, concomitant exacerbation malondialdehyde nitric oxide levels, α-chymotrypsin, ATPase, acetylcholinesterase...

In the present study, we investigated therapeutic effect of xylitol on glycogen content, oxidative stress, purinergic and cholinergic dysfunction, lipid dysmetabolism in hepatic tissue diabetic rats. Seven-week-old male Sprague-Dawley rats were divided into five groups as follows: normal control (NC), (DC), 5% (DX5), 10% (DX10), 20% (DX20). Type 2 diabetes (T2D) was induced groups, after confirmation diabetes, supplied with their respective solutions. After 8 weeks intervention period,...

Alteration in brain glucose metabolism due to uptake reduction has been described the onset of certain neurodegenerative disorders. This study determined Harpephyllum caffrum fruit's potential ability improve and its modulatory effects on intrinsic antioxidant, glucogenic, cholinergic, nucleotide-hydrolyzing enzyme activities isolated rat brain. Consequently, bioactive compounds fruits were identified with LC–MS. The fruit significantly improved following coincubation tissue. extract also...

Objective: To explore the antioxidant and antidiabetic activities of Rhus longipes (R. longipes) leaf stem bark aqueous infusions. Methods: R. infusions were characterized via gas-chromatography mass-spectroscopy (GC-MS) analysis. In vitro carbohydrate lipid digestive enzyme inhibitory determined. Additionally, modulatory effects on intestinal glucose absorption, muscle uptake, biomarkers renal oxidative injury evaluated. Molecular docking was performed to determine binding affinities...

Cannabis sativa L. is a crop utilized globally for recreational, therapeutic, and religious purposes. Although considered as an illicit drug in most countries, C. until recently started gaining attention its medicinal application. This study sought to investigate the hepatoprotective effect of on iron-mediated oxidative hepatic injury. Hepatic injury was induced ex vivo by incubating tissues with Fe2+, which led depleted levels reduced glutathione, superoxide dismutase, catalase ENTPDase...

The impact of ligand substituents and anion variation on the bio-activity pyridinyl Ag(I) complexes was evaluated. showed potential therapeutic ability with notable anticancer, antioxidant, antimicrobial activities.