This study was designed to determine the antioxidant properties and inhibitory effects of extract from Moringa oleifera leaves on angiotensin-I-converting enzyme (ACE) arginase activities in vitro. The prepared phenolic (total phenols flavonoid) contents, radical (nitric oxide (NO), hydroxyl (OH)) scavenging abilities, Fe(2+)-chelating ability were assessed. Characterization constituents done via high performance liquid chromatography-diode array detection (HPLC-DAD) analysis. Furthermore,...

This study was designed to evaluate and compare the interactions of essential oils from orange (Citrus sinensis [L.] Osbeck) lemon limon) peels on enzymes linked type-2 diabetes (α-amylase α-glucosidase) hypertension (angiotensin-I-converting enzyme [ACE]). The were obtained by hydrodistillation passed over anhydrous sodium sulphate. interaction oil α-amylase, α-glucosidase, ACE activities subsequently determined. results revealed that inhibited α-amylase α-glucosidase activities. However,...

This study sought to investigate the effects of essential oil from lemon (Citrus limoni) peels on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities in vitro. The was extracted by hydrodistillation, dried with anhydrous Na2SO4 characterized using gas chromatography. Antioxidant properties inhibition pro-oxidant-induced lipid peroxidation rats brain homogenate were also assessed. inhibited AChE BChE a concentration-dependent manner. GC analysis revealed presence sabinene,...

This study was designed to evaluate the antioxidant and cholinesterase inhibitory activities of sulfated polysaccharides from Gracilaria gracilis (PGCL) Ulva lactuca (PULV). PGCL PULV were extracted characterized with Scanning electron microscope-energy dispersive x-ray (SEM-EDX), Fourier transform infrared spectroscopy (FTIR) Gas chromatography-mass (GC-MS). The radical (2,2-azinobis-3-ethylbenzothiazoline-6-sulfonate [ABTS] 2,2-diphenyl-1- picrylhydrazyl [DPPH], hydroxyl [OH]) scavenging...

Over 90 % of all cases diabetes that have been diagnosed are type 2 (T2D), a disease exacerbated by an increase in sedentary behaviour, bad eating habits, and obesity. This study investigated the antidiabetic properties

This study was designed to assess the antioxidant, antidiabetic and antihypertensive effects of essential oils from A. melegueta danielli seeds. The were extracted via hydrodistillation, dried with anhydrous Na2SO4 characterized using gas chromatography-mass spectrometry (GC-MS). Antioxidant properties inhibition some pro-oxidant induced lipid peroxidation in rats' pancreas heart homogenates also determined. results revealed that eugenol, eucalyptol, α-terpineol, α-caryophyllene...

Microalgae are aquatic chlorophyll-containing organisms comprising unicellular microscopic forms, and their biomasses potential sources of bioactive compounds, biofuels food-based products. However, the neuroprotective effects microalgal biomass have not been fully explored. In this study, from two Chlorella species was characterized, antioxidant, anticholinesterase anti-amyloidogenic activities were investigated. GC–MS analysis extracts revealed presence some phenols, sterols, steroids,...

The inhibition of enzymes involved in the breakdown carbohydrates is considered a therapeutic approach to management type-2 diabetes. This study sought investigate effects essential oil from clove bud on α-amylase and α-glucosidase activities. Essential was extracted by hydrodistillation, dried with anhydrous Na2SO4 characterized using gas chromatography-mass spectrometry (GC-MS). activities were investigated. antioxidant properties Fe(2+) sodium nitroprusside-induced malondialdehyde (MDA)...

This study sought to investigate the effects of Raffia palm (Raphia hookeri) leaf extract on enzymes linked type-2 diabetes mellitus (T2DM) and pro-oxidant induced oxidative stress in rat pancreas. The was prepared its α-amylase α-glucosidase inhibitory were determined. Radical [2,2-diphenyl-1-picrylhydrazyl (DPPH)] scavenging Fe2+-chelating abilities, inhibition Fe2+-induced lipid peroxidation pancreas homogenate assessed. Furthermore, total phenol flavonoid contents, reducing property,...

Context: Seaweeds contain bioactive compounds with different biological activities. They are used as functional ingredients for the development of therapeutic agents to combat degenerative diseases. Objective: This study investigated phenolic composition, antioxidant activity, cholinesterase inhibitory and anti-amyloidogenic activities aqueous extracts Gracilaria beckeri (J.Agardh) Papenfuss (Gracilariaceae) (RED-AQ), Ecklonia maxima (Osbeck) (Lessoniaceae) (ECK-AQ), Ulva rigida (C.Agardh)...

This study investigated the inhibitory effects of phenolic-rich extracts from Clerodendrum volubile leaves on cholinergic [acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)] monoaminergic [monoamine oxidase (MAO)] enzymes' activities pro-oxidants [Fe2+ quinolinic acid-(QA)] induced lipid peroxidation in rats brain homogenates vitro. Free phenolic (FPE) bound (BPE) were obtained via solvent extraction, total phenol flavonoid contents evaluated. The constituents also determined...

Abstract Background Sulfated polysaccharides from marine algae are known to possess antioxidative activities, however, their therapeutic role in metal-induced neurodegeneration has not been explored. In this study, the neuroprotective potentials of sulfated isolated Ecklonia maxima (PKPM), Gelidium pristoides (PMNP), Ulva lactuca (PULV), rigida (PURL) and Gracilaria gracilis (PGCL) against Zn-induced rats’ hippocampal neuronal cells (HT-22) were assessed. Methods Cells cultured maintained at...

This study sought to assess the effects of bitter gourd leaf extracts (methanol and aqueous) on enzyme linked with hypertension (angiotensin-I-converting some pro-oxidants (iron sulfate, sodium nitroprusside, cisplatin]-induced lipid peroxidation in rat kidney homogenates. Chromatographic analysis extract was done using high-performance liquid chromatography-diode array detection. The results revealed that methanol (IC50 = 109.63 µg/mL) had significantly (P < .05) higher angiotensin-I...

This study was designed to determine the neuroprotective potentials of aqueous and methanol extracts from Heinsia crinita leaves in vitro. The total phenol flavonoid contents were determined using colorimetric method while phenolic characterization leaf analyzed via high performance liquid chromatography-diode array detector (HPLC-DAD). effects on Fe2+-induced lipid peroxidation rats' brain homogenate, monoamine oxidase (MAO), Na+/K+-ATPase, acetylcholinesterase (AChE) butyrylcholinesterase...