This research investigated the effect of blanching on phenolic distribution and in vitro antioxidant anticholinesterase properties HCl-methanolic extracts from fireweed. Phenolic-rich were prepared by extracting powdered blanched unblanched fireweed leaves with a mixture absolute 1 M HCl methanol (1:1 v/v). The constituents analysed using high-performance chromatography coupled to diode array detector (HPLC-DAD). Furthermore, extracts' [1,1-diphenyl-2-picrylhydrazyl (DPPH),...

This study sought to assess the effects of bitter gourd leaf extracts (methanol and aqueous) on enzyme linked with hypertension (angiotensin-I-converting some pro-oxidants (iron sulfate, sodium nitroprusside, cisplatin]-induced lipid peroxidation in rat kidney homogenates. Chromatographic analysis extract was done using high-performance liquid chromatography-diode array detection. The results revealed that methanol (IC50 = 109.63 µg/mL) had significantly (P < .05) higher angiotensin-I...

Background . This study sought to investigate the antioxidant and antihyperglycemic properties of Musa sapientum (Latundan banana) (MSL), acuminata (Cavendish (MAC), acuminate (Red Dacca) (MAR). Materials Methods. The sugar, starch, amylose, amylopectin contents glycemic index (GI) three banana cultivars were determined. Furthermore, total phenol vitamin C α -amylase -glucosidase inhibitory effects samples also Results MAC MAR had highest estimated (eGI) with no significant different while...

Aluminum (Al)-induced toxicity in fruit fly (Drosophila melanogaster) is one of the established models for studying neurotoxicity and neurodegenerative diseases. Alkaloid phytochemicals have been reported to exhibit neuroprotective effects. Therefore, aim this study determine effect alkaloid extracts Andrographis paniculata Phyllanthus amarus leaves on Al-induced wild type Drosophila melanogaster. The flies were exposed diets containing 40 mM AlCl3, (0.1 1 mg/ml). Thereafter, assessed...

This study emphasized on the neuroprotective properties of bitter leaf alkaloid-rich extract (BLAE) using transgenic fruit fly (Drosophila melanogaster [D. melanogaster]) model and scopolamine-induced amnesia rats. In vitro antioxidant modulatory effects key neuronal enzymes were carried out. Thereafter, flies expressing human amyloid precursor protein (hAPP) BACE-1 genes treated with BLAE for 7 d to determine survival rate, BACE-1, acetylthiocholine (AChE), glutathione-S-transferase (GST),...

This study aims to evaluate the neuroprotective effect of caffeic acid (CAF) against cadmium chloride (CdCl

Abstract Carica papaya, commonly known as pawpaw, is a tropical plant cultivated for its edible ripe fruits. However, leaf being use traditionally against several life‐threatening illnesses, including Alzheimer disease (AD). This study compared the cholinesterases (ChEs) inhibitory effect and antioxidant property of alkaloid phenolic [aqueous, acetone methanol‐HCL (0.1:50 w/v)] rich extracts Pawpaw leaf. The were prepared to concentration 2 mg/mL, thereafter, on ChEs [acetylcholinesterase...

Abstract The distribution of phytochemicals and their contribution to antioxidant potentials in whole dehulled Bambara groundnut (BGN) seeds was evaluated. Whole BGN were sorted using the testa hilium colour further grouped into seeds. Extractions both done methanol extracts assayed for total phenolics (TPC), flavanol, flavonol, anthocyanin content, oxygen radical absorbance capacity (ORAC) ferric reducing power (FRAP). Methanolic extract seed exhibited higher flavanol flavonol content as...

Abstract This study was designed to investigate the influence of cooking on glycemic index (GI), amylose, and amylopectin contents two rice varieties. Two varieties (foreign long ofada) were sourced for, divided into two, one portion cooked other used raw. The sugar, starch, as well indices, antioxidant properties, ability inhibit carbohydrate‐hydrolyzing enzymes (α‐amylase α‐glucosidase) determined. In addition, polyphenol content results revealed that caused a significant increase in...

Pepperfruit (Dennettia tripetala G. Baker (Annonaceae) is a well-known Nigerian spicy medicinal plant normally used in folk medicine to cure fever, cough, toothache, as well stimulant and the preparation of some special dishes for pregnant postpartum women. The present study sought assess antioxidant properties aqueous extract ripe (RPF) unripe pepperfruit (UPF) extract. pepperfruits were prepared, their phytoconstituents (total phenol, total flavonoid ascorbic acid) activities...

Summary This study sought to assess the effect of processing yam flour [from white ( Dioscorea rotundata ) and water alata )] paste, on antioxidant properties inhibition key enzymes linked type‐2 diabetes (α‐amylase α‐glucosidase). The phenolic content (phenol flavonoid), properties, α‐amylase α‐glucosidase inhibitory aqueous extracts products were determined. Processing into paste caused significant P &lt; 0.05) percentage decrease in their total phenol flavonoid varieties. However,...

Diabetes mellitus (DM) is a chronic metabolic disorder linked to cognitive impairment and memory deficit, known as diabetes encephalopathy. This study examined the anti-diabetic neuroprotective effects of alkaloid extracts from Andrographis paniculata (A. paniculata) Phyllanthus amarus (P. amarus) leaves, Traditional Chinese Medicine, on carbohydrate-metabolizing (α-amylase α-glucosidase) enzyme, cholinesterase purinergic enzyme activities, antioxidants in brains streptozotocin (STZ)-induced...

Andrographis paniculata is a medicinal herb that used to treat various disease conditions due its pharmacological properties. Thus, this study sought assess the effect of A. extract on neurobehavioral and some biochemical parameters in scopolamine-induced amnesic rats. Thirty-five male rats were divided into seven groups treated with aqueous (50 500 mg/kg) donepezil (5 for 14 days before administration scopolamine. Behavioral studies (Morris water maze Y-maze) carried out evaluate cognitive...

In a bid to make the use of functional food easier in management and prevention diseases, product development fortification from/with foods have become recent focus research. This study, therefore, sought exploit trend brewing industry on production non-alcoholic beers by investigating possibility having beer flavored with bitter leaf, known plant widely reported strong hypoglycemic effect, as against traditional hops, effect produced glycemic indices various diabetic biochemical parameters...

This study is aimed at assessing the inhibitory effect of teas on key enzymes (α-amylase and α-glucosidase) linked with type-2 diabetes their antioxidant properties. Four samples three brands were used; infusions green tea (GT), 2 black (BT), a formulated herbal preparation for (ADT) (white tea, Radix Puerariae, ophiopogonis, hawthorn berry, Chinese yam, fragrant Solomon seal rhizome) prepared subsequently analyzed total phenol, ascorbic acid contents, properties (2,2-Azizobis...

Heinsia crinita; a common vegetable in the south-eastern part of Nigeria with local name “Atama” have been used as component various herbal portions ethnomedicine. The plant has previously treatment umbilical hernia and skin rashes. There is dearth information on scientific rationale behind use this plant. This study was designed to investigate pharmacological potentials aqueous extracts crinita for management/prevention hypertension. Fresh, matured green leaves were harvested from farm...

This study evaluated the effect of dietary inclusions aspartame and sucrose on some selected behavioral biochemical indices linked with Alzheimer's disease in a transgenic fruit fly (Drosophila melanogaster) model expressing human amyloid precursor protein secretase. Flies were raised diet supplemented for 14 days. Thereafter, flies assessed their survival rate, learning memory, as well locomotor performance, days post-treatment. was followed by homogenising heads, homogenates assayed...

The present study aimed at investigating the effect of Terminalia catappa fruits on blood pressure, NO/cGMP signalling pathway, angiotensin-1-converting enzyme and arginase activity, oxidative stress biomarkers in L-NAME-induced hypertensive rats.Forty-two Wistar rats were divided into seven groups. Hypertension was induced via oral administration 40 mg/kg L-NAME for 21 days. Thereafter, treated with fruit-supplemented diet sildenafil citrate pressure measured cardiac homogenate prepared...

Abstract Background This study was carried out to investigate the antidiabetic activity of acarbose produced by Actinoplanes specie isolated from selected soils in streptozotocin induced diabetic rats. Acarbose utahensis purified consecutively with dialysis, gel filtration and high-performance liquid chromatography, test isolate can be exploited for large scale production acarbose. Results Seven species ( missouriensis, utahensis, aureus, ramoplaninifer, rhizophilus auranticolour...