Caffeic acid (CAA) and chlorogenic (CHA) are important members of hydroxycinnamic with natural antioxidant cardio-protective properties. The present study aimed to determine the effect CAA CHA on systolic blood pressure, heart rates (HR) as well activity angiotensin-1-converting enzyme (ACE), acetylcholinesterase (AChE), butrylcholinesterase (BChE) arginase in cyclosporine-induced hypertensive rats. Experimental rats were distributed into 7 groups (n = 6): normotensive control rats; (induced...

This study sought to investigate the anticholinesterase and antioxidative properties of quercetin its glycosylated conjugate, rutin. The in vitro inhibition acetylcholinesterase (AChE) butyrylcholinesterase (BChE) activities, Fe(2+)-induced lipid peroxidation rat's brain homogenates, radicals scavenging, Fe(2+)-chelating abilities flavonoids were investigated with concentrations samples ranging from 0.06 0.6 mM. Quercetin had significantly higher AChE BChE inhibitory than also stronger...

This study was designed to determine the antioxidant properties and inhibitory effects of extract from Moringa oleifera leaves on angiotensin-I-converting enzyme (ACE) arginase activities in vitro. The prepared phenolic (total phenols flavonoid) contents, radical (nitric oxide (NO), hydroxyl (OH)) scavenging abilities, Fe(2+)-chelating ability were assessed. Characterization constituents done via high performance liquid chromatography-diode array detection (HPLC-DAD) analysis. Furthermore,...

Studies have supported the protective effect of high fruit consumption in management chronic diseases such as diabetes. Thirteen fresh tropical fruits were sourced for and juices extracted, freeze dried, then reconstituted analysis. The sugar, starch, amylose, amylopectin contents well glycemic indices, antioxidant properties, ability to inhibit starch-hydrolyzing enzymes determined. Also, phenolic constituents characterized using high-performance liquid chromatography coupled with diode...

This study was designed to evaluate and compare the interactions of essential oils from orange (Citrus sinensis [L.] Osbeck) lemon limon) peels on enzymes linked type-2 diabetes (α-amylase α-glucosidase) hypertension (angiotensin-I-converting enzyme [ACE]). The were obtained by hydrodistillation passed over anhydrous sodium sulphate. interaction oil α-amylase, α-glucosidase, ACE activities subsequently determined. results revealed that inhibited α-amylase α-glucosidase activities. However,...

This study sought to investigate the effects of essential oil from lemon (Citrus limoni) peels on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities in vitro. The was extracted by hydrodistillation, dried with anhydrous Na2SO4 characterized using gas chromatography. Antioxidant properties inhibition pro-oxidant-induced lipid peroxidation rats brain homogenate were also assessed. inhibited AChE BChE a concentration-dependent manner. GC analysis revealed presence sabinene,...

Spices are used in soup preparation many homes and serve as ingredients the of several traditional delicacies endowed with natural antioxidants such polyphenols. The aim this study is to evaluate effect aqueous extract garlic, white onion, purple onion on angiotensin-converting enzyme, α-amylase, α-glucosidase activity vitro determine their antioxidant properties via various assays OH*, Fe2+ chelation, 2, 2'-azino-bis 3-ethylbenzothiazoline-6-sulphonic acid (ABTS) radical-scavenging assays....

Abstract Background: Avocado pear ( Persea americana Mill.) leaves and seeds are used in traditional medicine for the treatment/management of Alzheimer disease (AD); however, information on mechanism actions is limited. This study sought to investigate effect P. leaf seed aqueous extracts some enzymes linked with AD (acetylcholinesterase [AChE] butyrylcholinesterase [BChE] activities) their antioxidant potentials vitro. Methods: The inhibitory effects AChE BChE activities (inhibition Fe 2+ -...

Huge quantities of citrus wastes, especially peels are generated globally and they an environmental menace in many parts the world. However, have been use folklore oriental medicines for management degenerative conditions this prompted researchers to investigate medicinal properties peels. Various research efforts showed that rich vitamins, fibers bioactive compounds. The possess antioxidant, antimicrobial, antidiabetic, antihypertensive, anti-inflammatory anticancer properties. benefits...

The antioxidant properties and effect of essential oil black pepper ( Piper guineense ) seeds on α -amylase, -glucosidase (key enzymes linked to type-2 diabetes), angiotensin-I converting enzyme (ACE) hypertension) were assessed. was obtained by hydrodistillation dried with anhydrous Na 2 SO 4 , the phenolic content, radical [1,1-diphenyl-2 picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) nitric oxide (NO)] scavenging abilities as well ferric reducing...

This study sought to investigate the possible mechanisms for use of phenolic extracts from grapefruit peels in management/prevention cardiovascular complications. The effects on key enzymes relevant diseases [3-hydroxy-methyl-3-glutaryl coenzyme A reductase (HMG-CoA reductase) and angiotensin-I converting enzyme (ACE)], cellular antioxidant activity human endothelial cells (EA.Hy 926) radicals [1,1-diphenyl-2 picrylhydrazyl (DPPH) 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid)...

Abstract Background: Anogeissus leiocarpus and Hunteria umbellata have been reportedly used in traditional medicine for the management of erectile dysfunction (ED). However, scientific basis their use has not well established. Therefore, this study was designed to investigate inhibitory effects water extractable phytochemicals H. A. on phosphodiesterase-5 (PDE-5) arginase as pro-oxidants induced lipid peroxidation rat penile tissue. Methods: The extracts important enzymes (PDE-5 arginase)...

Sexual dysfunction is a side effect of the antidepressant drug paroxetine. Anogeissus leiocarpus medicinal plant with wide range biological activities which include antioxidant and antiulcer properties. With these in mind, we investigated stem bark extract on paroxetine-induced sexual male Wistar rats. Forty-two adult rats were divided into seven experimental groups: normal control, PAR (10 mg/kg), + sildenafil (5 ALE (50 100 mg/kg) mg/kg). The experiment lasted for 21 days, after subjected...

This study was designed to compare the chemical compositions and effect of essential oils from peels seeds sweet orange on cholinergic (acetylcholinesterase [AChE], butyrylcholinesterase [BChE]) monoaminergic (monoamine oxidase [MAO]) enzymes. The ability protect brain against Fe2+-induced lipid peroxidation also investigated. Forty forty-four compounds were identified in seed oils, respectively, using gas chromatography. inhibited AChE, BChE MAO dose-dependent manner. However, oil had...

The inhibition of enzymes involved in the breakdown carbohydrates is considered a therapeutic approach to management type-2 diabetes. This study sought investigate effects essential oil from clove bud on α-amylase and α-glucosidase activities. Essential was extracted by hydrodistillation, dried with anhydrous Na2SO4 characterized using gas chromatography-mass spectrometry (GC-MS). activities were investigated. antioxidant properties Fe(2+) sodium nitroprusside-induced malondialdehyde (MDA)...

This study investigated the inhibitory effects of phenolic-rich extracts from Clerodendrum volubile leaves on cholinergic [acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)] monoaminergic [monoamine oxidase (MAO)] enzymes' activities pro-oxidants [Fe2+ quinolinic acid-(QA)] induced lipid peroxidation in rats brain homogenates vitro. Free phenolic (FPE) bound (BPE) were obtained via solvent extraction, total phenol flavonoid contents evaluated. The constituents also determined...

ABSTRACT This study sought to characterize the interaction of phenolic extract from grapefruit peels with α-amylase, α-glucosidase and angiotensin-I-converting enzyme (ACE) activities. The free was extracted 80% acetone, while bound alkaline acid-hydrolyzed residue ethyl acetate; their enzymes were assessed. extracts inhibited ACE activities; however, had significantly higher (P < 0.05) α-amylase inhibitory activities than phenolic, there no significant difference > in Nevertheless, strong...

Background . This study sought to investigate the antidiabetic and antihypertensive mechanisms of cocoa ( Theobroma cacao ) bean through inhibition α-amylase, α-glucosidase, angiotensin-1 converting enzyme, oxidative stress. Methodology The total phenol flavonoid contents water extractable phytochemicals from powdered were determined effects extract on enzyme activities investigated in vitro Furthermore, radicals [1,1-diphenyl-2 picrylhydrazyl (DPPH),...