A5002462984- Sodium Intake and Health
- Vitamin C and Antioxidants Research
- Fluoride Effects and Removal
- Hormonal Regulation and Hypertension
- Drug-Induced Hepatotoxicity and Protection
- Natural Antidiabetic Agents Studies
- Trace Elements in Health
- Medicinal Plants and Neuroprotection
- Antioxidant Activity and Oxidative Stress
- Blood Pressure and Hypertension Studies
- Heavy Metal Exposure and Toxicity
- Biochemical effects in animals
- Nitric Oxide and Endothelin Effects
- Arsenic contamination and mitigation
- Acute Kidney Injury Research
- Aldose Reductase and Taurine
- Phytochemicals and Medicinal Plants
- Effects and risks of endocrine disrupting chemicals
- Moringa oleifera research and applications
- Carcinogens and Genotoxicity Assessment
- Tea Polyphenols and Effects
- Ethnobotanical and Medicinal Plants Studies
- Curcumin's Biomedical Applications
- Tryptophan and brain disorders
- Hibiscus Plant Research Studies
University of Ibadan
2016-2025
Pan-Atlantic University
2022
University College Hospital, Ibadan
2022
Cape Peninsula University of Technology
2022
Texas Southern University
2022
Caffeic acid (CAA) and chlorogenic (CHA) are important members of hydroxycinnamic with natural antioxidant cardio-protective properties. The present study aimed to determine the effect CAA CHA on systolic blood pressure, heart rates (HR) as well activity angiotensin-1-converting enzyme (ACE), acetylcholinesterase (AChE), butrylcholinesterase (BChE) arginase in cyclosporine-induced hypertensive rats. Experimental rats were distributed into 7 groups (n = 6): normotensive control rats; (induced...
ABSTRACT Human exposure to sodium fluoride through its daily usage is almost inevitable. Cardiovascular and renal dysfunction has been associated with toxicity. Therefore, this study investigated the mechanism of action (NaF) induced hypertension cardiovascular complications Forty male albino rats an average 10 per group were used. Group A received clean tap water. Toxicity was in B D by administering graded doses NaF drinking water ad libitum for days at 150 ppm, 300 600 ppm concentration...
Abstract Hypertension is one of the silent killers in world with high mortality and morbidity. The exposure humans animals to fluoride and/or containing compounds almost inevitable. This study investigated modulatory effects quercetin on sodium (NaF)‐induced hypertension cardiovascular complications. Forty male rats were randomly separated into four groups ( n =10). Group A served as control, B exposed 300 ppm NaF, Groups C D NaF along orally at 50 mg/kg 100 by gavage, while was administered...
The use of sodium fluoride (NaF) as a major ingredient for tooth paste, mouth wash, and rinse has become inevitable in our day-to-day life. However, flavonoids such Luteolin might be great value the prevention toxicity associated with accidental or ingestion NaF. In study, 40 male Wistar albino rats were randomly divided into four groups 10 group. Group A was control group received normal saline, B exposed to NaF at 300 ppm (300 mg/L) drinking water daily week, Groups C D coadministered...
Diazinon is a commonly used organophosphate (OP) insecticide especially in developing countries for the control of insect pests, however, exposure to its toxic impact humans and other non-target species remains an important public health concern. The study aimed investigate effect epigallocatechin -3- gallate (EGCG), abundant green tea plants on neurobehavioural, biochemical, pathological changes brain male Wistar rats following diazinon toxicity. Sixty adult were acclimatized seven days...
Moringa oleifera (MO) has been recognized for its numerous beneficial properties. This study aimed to evaluate the potential antihypertensive effects of MO seeds in rats subjected Nω-nitro-L-arginine methyl ester (L-NAME) exposure. Fifty male Wistar were randomly divided into five groups 10 each experiment. Group A served as control, received normal saline only, B L-NAME (40 mg/kg) C + 10% feed, D 20% and E Lisinopril (10 mg/kg). Treatment was daily covered a period 5 weeks. Blood pressure...
Abstract : The seeds of Moringa oleifera were collected, air-dried, pulverized, and subjected to cold extraction with methanol. methanol extract was screened phytochemically for its chemical components used acute sub-acute toxicity studies in rats. phytochemical screening revealed the presence saponins, tannins, terpenes, alkaloids, flavonoids, carbohydrates, cardiac glycosides but absence anthraquinones. Although signs observed at a dose 4,000 mg kg − 1 test, mortality recorded 5,000 , no...
Abstract Environmental and occupational exposure to chromium compounds has become potential aetiologic agent for kidney disease with excessive generation of free radicals, apoptosis, inflammatory. These pathophysiologic mechanisms potassium dichromate (K 2 Cr O 7 ) have been well correlated nephrotoxicity cardiotoxicity. The cardioprotective nephroprotective effects Luteolin, a known potent antioxidant were evaluated in this study 40 healthy rats four experimental groups: Group A (normal...
The toxic effects of oral administration the methanol extract of Moringa oleifera seed at 0,400, 800 and 1600 mg/kg was investigated in Wistar rats after 21 days treatment. Treatment with did not significantly (P > 0.05) alter levels hemoglobin, red blood cell, packed cell volume, mean corpuscular volume hemoglobin concentration. In rats, also, total protein, albumin globulin treated animals were different from control. however induced significant decrease (P<0.05) concentrations platelets,...
Abstract Studies of the link between environmental pollutants and cardiovascular dysfunction, neglected for decades, have recently provided new insights into pathology consequences these killers. In this study, rats were divided four groups, each containing 10 rats. The in group one served as controls administered normal saline, whereas two orally gavaged with 3 mg/kg diazinon (DZN) alone twenty consecutive days. groups 4 respective 60 120 gallic acid (GA) addition to DZN Exposure...
Sodium fluoride is one of the neglected environmental contaminants. Inorganic fluorides in environment are found air, water, and land. In study, forty-male Wistar albino rats were randomly divided into four groups with 10 a group. Group A was control group which given normal saline, B exposed to 300 ppm NaF drinking while Groups C D received along Rutin (100 mg/kg 200 mg/kg) orally daily for week. Administration alone led significant increases blood pressure, deceased serum nitric oxide....
Biologically active compounds such as caffeine and caffeic acid can be obtained in plants especially cocoa coffee. Hence, the combinatory effect of well their individual were assessed on activities arginase, angiotensin-1-converting enzyme (ACE) nitric oxide (NOx), malondialdehyde (MDA) level Nω-Nitro-L-arginine-methylester (L-NAME)-induced hypertensive rats. The investigated L-NAME-induced Animals grouped into eleven containing six animals each. Hemodynamic parameter was determined by...
Abstract Background The important roles of liver and kidney in the elimination injurious chemicals make them highly susceptible to noxious activities various toxicants including cobalt chloride (CoCl 2 ). This study was designed investigate role glycine mitigation hepato‐renal toxicities associated with CoCl exposure. Methods Forty‐two (42) male rats were grouped as Control; ; 300 ppm); + Glycine (50 mg/kg); (100 mg/kg). markers hepatic renal damage, oxidative stress, antioxidant defense...
The use of doxorubicin (DOX) as an antineoplastic agent has been greatly limited because the myriad toxic sequelae associated with it. aim this study was to assess protective effects gallic acid (GA) on DOX-induced cardiac toxicity in rats.Sixty male rats (Wistar strain) were used study. They divided into six groups (A-F) each containing 10 animals. Group A control. Rats Groups B, C, and D treated DOX at dosage 15 mg/kg body weight i.p. Prior treatment, C had orally GA for 7 days 60 120...
Hypertension is the most common cardiovascular disease that affects approximately 26% of adult population, worldwide. Rutin one important flavonoids consumed in daily diet, and found many food items, vegetables, beverages. Uninephrectomy (UNX) left kidney was performed, followed by induction hypertension. The rats were randomly divided into four groups 10 rats: group 1—Sham-operated rats; 2—UNX rats, 3—UNX-L-NAME (40 mg/kg) plus rutin (100 mg/kg bwt), 4—UNX-L-NAME lisinopril (10 orally for 3...
Alchornea cordifolia leaf is traditionally used for the treatment of venereal diseases and enhancement fertility throughout its area distribution in Africa. The effect oral administration methanol extract was evaluated on some reproductive haematological parameters male rats at 0 (control group), 100, 200, 400, 800 1600 mg kg(-1) . toxicity study revealed nonsignificant alterations (P > 0.05) values total differential white blood cell count, but erythrocyte packed volume, haemoglobin...
Cobalt (Co) toxicity is a potential public health problem due to recent renewed use of Co in orthopedic implants, dietary supplements, and blood doping athletes horses. We investigated the protective roles kolaviron (KV), bi-flavonoid Garcinia kola, gallic acid (GA) on cobalt chloride (CoCl2)-induced cardiorenal damage rats. CoCl2 caused significant increases (p < 0.05) serum creatine kinase-myocardial band (CK-MB), lactate dehydrogenase (LDH), aspartate transaminase (AST), xanthine oxidase...
Azadirachta indica (AI) is a medicinal plant with reported antioxidant and cardio-protective properties. The use of plant-based polyphenols has become greatly increased in the last one decade. present study investigated protective effect polyphenol-rich fraction (PRF) methanol-extract against Nω-Nitro-L-Arginine Methyl Ester (L-NAME) induced hypertension cardiorenal dysfunction rats. Fifty (50) Wistar albino rats were grouped into five groups. Group A, control, was administered potable...
Rhizome (CLR), due to its potent antioxidant phytochemical constituents, was investigated for effects on bisphenol A (BPA)-induced cardiovascular and renal damage.