A5021408234- Sodium Intake and Health
- Fluoride Effects and Removal
- Vitamin C and Antioxidants Research
- Hormonal Regulation and Hypertension
- Blood Pressure and Hypertension Studies
- Drug-Induced Hepatotoxicity and Protection
- Chemotherapy-induced cardiotoxicity and mitigation
- Eicosanoids and Hypertension Pharmacology
- Cynara cardunculus studies
- Cardiac electrophysiology and arrhythmias
- Acute Kidney Injury Research
- Veterinary Pharmacology and Anesthesia
- Trypanosoma species research and implications
- Phytochemicals and Antioxidant Activities
- Nitric Oxide and Endothelin Effects
- Phytochemistry and Biological Activities
- Cancer Treatment and Pharmacology
- Receptor Mechanisms and Signaling
- Animal Virus Infections Studies
- Natural Antidiabetic Agents Studies
- Psidium guajava Extracts and Applications
- SARS-CoV-2 and COVID-19 Research
- Arsenic contamination and mitigation
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Virus-based gene therapy research
University of Ibadan
2016-2025
University of Veterinary Medicine
2016
Abstract Hypertension is one of the silent killers in world with high mortality and morbidity. The exposure humans animals to fluoride and/or containing compounds almost inevitable. This study investigated modulatory effects quercetin on sodium (NaF)‐induced hypertension cardiovascular complications. Forty male rats were randomly separated into four groups ( n =10). Group A served as control, B exposed 300 ppm NaF, Groups C D NaF along orally at 50 mg/kg 100 by gavage, while was administered...
The use of sodium fluoride (NaF) as a major ingredient for tooth paste, mouth wash, and rinse has become inevitable in our day-to-day life. However, flavonoids such Luteolin might be great value the prevention toxicity associated with accidental or ingestion NaF. In study, 40 male Wistar albino rats were randomly divided into four groups 10 group. Group A was control group received normal saline, B exposed to NaF at 300 ppm (300 mg/L) drinking water daily week, Groups C D coadministered...
Moringa oleifera (MO) has been recognized for its numerous beneficial properties. This study aimed to evaluate the potential antihypertensive effects of MO seeds in rats subjected Nω-nitro-L-arginine methyl ester (L-NAME) exposure. Fifty male Wistar were randomly divided into five groups 10 each experiment. Group A served as control, received normal saline only, B L-NAME (40 mg/kg) C + 10% feed, D 20% and E Lisinopril (10 mg/kg). Treatment was daily covered a period 5 weeks. Blood pressure...
Sodium fluoride is one of the neglected environmental contaminants. Inorganic fluorides in environment are found air, water, and land. In study, forty-male Wistar albino rats were randomly divided into four groups with 10 a group. Group A was control group which given normal saline, B exposed to 300 ppm NaF drinking while Groups C D received along Rutin (100 mg/kg 200 mg/kg) orally daily for week. Administration alone led significant increases blood pressure, deceased serum nitric oxide....
Abstract Fluoride is an environmental contaminant that ubiquitously present in air, water, and soil. It commonly added minute quantity to drinking toothpaste, mouth rinses prevent tooth decay. Epidemiological findings have demonstrated exposure fluoride induced neurodevelopmental toxicity, developmental neurotoxicity, motor disorders. The neuroprotective effect of clofibrate, a peroxisome proliferator‐activated receptor alpha agonist, was investigated the study. Forty male Wistar rats were...
The use of doxorubicin (DOX) as an antineoplastic agent has been greatly limited because the myriad toxic sequelae associated with it. aim this study was to assess protective effects gallic acid (GA) on DOX-induced cardiac toxicity in rats.Sixty male rats (Wistar strain) were used study. They divided into six groups (A-F) each containing 10 animals. Group A control. Rats Groups B, C, and D treated DOX at dosage 15 mg/kg body weight i.p. Prior treatment, C had orally GA for 7 days 60 120...
Hypertension is the most common cardiovascular disease that affects approximately 26% of adult population, worldwide. Rutin one important flavonoids consumed in daily diet, and found many food items, vegetables, beverages. Uninephrectomy (UNX) left kidney was performed, followed by induction hypertension. The rats were randomly divided into four groups 10 rats: group 1—Sham-operated rats; 2—UNX rats, 3—UNX-L-NAME (40 mg/kg) plus rutin (100 mg/kg bwt), 4—UNX-L-NAME lisinopril (10 orally for 3...
Azadirachta indica is widely distributed in Africa, Asia and other tropical parts of the world. A. (AI) traditionally used for treatment several conditions including cancer, hypertension, heart diseases skin disorders. Intestinal ischaemia-reperfusion a common pathway many may lead to multiple organ dysfunction syndrome death. In this study, we investigated ameliorative effects AI on intestinal injury-induced cardiorenal dysfunction. Sixty rats were divided into 6 groups; each containing 10....
Sodium arsenite (NaAsO2) is one of the major environmental toxicants with severe toxicological consequences in some developing and developed countries. Rats Group A received normal saline. Genotoxicity apoptosis were induced by single intraperitoneal injection 10 mg/kg sodium to rats Groups B–F. C D had earlier been pretreated Azadirachta indica (100 200 mg/kg) or E F vitamin (50 100 mg/kg), respectively. Markers oxidative stress, inflammation, hepatic damage, genotoxicity, assessed....
Azadirachta indica (AI) is a medicinal plant with reported antioxidant and cardio-protective properties. The use of plant-based polyphenols has become greatly increased in the last one decade. present study investigated protective effect polyphenol-rich fraction (PRF) methanol-extract against Nω-Nitro-L-Arginine Methyl Ester (L-NAME) induced hypertension cardiorenal dysfunction rats. Fifty (50) Wistar albino rats were grouped into five groups. Group A, control, was administered potable...
Abstract Background: Toxicities due to fluoride exposure from natural and industrial sources occur commonly in man animals with severe consequences ranging mild cardiac derangements sudden death. In this study, we investigated the protective effects of methanol extract Azadirachta indica (AI) against sodium (NaF)-induced hypertension genotoxicity rats. Methods: Sixty rats were divided into six groups ten each as follows: Group A, control group received distilled water; B administered NaF at...
Acute renal failure (ARF) has been documented as a life-threatening disease with high morbidity and mortality. We investigated the protective effect of Luteolin against ARF. In this study, forty-male Wistar albino rats were randomly divided into four groups (n = 10). Group A received normal saline. B glycerol (10 ml/kg BW, 50% v/v in sterile saline, i.m.). Groups C D pretreated 100 200 mg/kg for 7 days, thereafter administered Glycerol Administration significantly increased systolic blood...
Cardiometabolic syndrome has been linked with dietary modification. Therefore, we investigated the effects of D-ribose-L-cysteine (DRLC) in rats fed high fructose fat (HFHF) diet. Twenty (n = 5), divided into 4 groups were concurrently exposed to HFHF and/or DRLC (250 mg/kg, p.o) during 8 weeks study. The result showed that compared control group, group had significant impairment lipid and glucose homeostasis, increased cardiac xanthine oxidase, systolic blood pressure, heart rate, %body...
Information on the occurrence of gastric lesions in pigs Ghana is lacking literature. This study was designed as a preliminary investigation to determine and pattern lesion Ghana. Ante-mortem animal assessment post-slaughter stomach evaluation were conducted 75 out total 694 slaughtered between October, 2014 March, 2015 at Kumasi abattoir. The gross observed mucosa graded using standard technique. Stomach contents assessed tissue sections used for histopathology evaluation. data obtained...
Increasing hypertension incidence in Sub-Sahara Africa and the current cost of management metabolic disorder has necessitated research on medicinal plants employed African Traditional Medicine for hypertension. Thus, this study evaluated antihypertensive effect Annona muricata leaves or Curcuma longa rhizomes experimentally-induced hypertensive male Wistar rats (n=70) which were unilaterally nephrectomized daily loaded with 1% salt. Cardiovascular haematological changes, as well urinalysis...
Trastuzumab (TZM) treatment is known to be associated with arrhythmogenic potentialwhich primarily the basis for its cardiotoxicity. The purpose of this study was investigate acute influence oral pretreatments 100 mg/kg/day Ocimun gratissimumethanolic leaf extract (OG) and fractions (petroleum ether,PEOG; ethyl acetate,EAOG; ethanolic extract, EOG) as well valsartan-lisinopril fixed dose combination (VAL-LSP) on electrocardiogram (ECG) Wistar rats intaperitoneally treated 2.25 TZMfor 7 days....
Lipid peroxidation is implicated in the development of hypertension and coronary artery disease, its deleterious impact exacerbated by estrogen (ETD) depletion post-menopausal women. We hypothesize that treatment with ETD antihyperlipidemic drugs, either alone or combination, can alleviate cardiovascular disease. In this study, female Wistar rats were divided into 10 groups (n = 6): Group 1 (control) underwent a Sham operation was fed standard rat chow, whereas other nine ovariectomized...