A5074115473- Essential Oils and Antimicrobial Activity
- Phytochemistry and Biological Activities
- Alkaloids: synthesis and pharmacology
- Berberine and alkaloids research
- Ethnobotanical and Medicinal Plants Studies
- Hormonal Regulation and Hypertension
- Tuberculosis Research and Epidemiology
- Sodium Intake and Health
- Synthesis and biological activity
- Natural product bioactivities and synthesis
- Plant Pathogens and Fungal Diseases
- Fluoride Effects and Removal
- Sesquiterpenes and Asteraceae Studies
- Herbal Medicine Research Studies
- Morinda citrifolia extract uses
- Quinazolinone synthesis and applications
- Pharmacological Effects of Natural Compounds
- Microbial Natural Products and Biosynthesis
- Fungal Biology and Applications
- SARS-CoV-2 and COVID-19 Research
- Phytochemistry and Bioactive Compounds
- Probiotics and Fermented Foods
- Animal Nutrition and Physiology
- Vitamin C and Antioxidants Research
- Garlic and Onion Studies
University of Pretoria
2015-2023
University of South Africa
2019-2023
Onderstepoort Veterinary Academic Hospital
2015-2023
University of Ibadan
2020
Antimicrobial resistance (AMR) remains an important global health issue but the gap between AMR and development of new antimicrobials is increasing. Plant extracts may have good activity per se or be sources effective antimicrobial compounds which can act against planktonic and/or biofilms pathogens. We determined efficacy cytotoxicity some under-investigated plants from Myrtaceae family endemic to South Africa. The ability plant inhibit destroy pre-formed bacterial was also determined.
Influenza infection is a major public health threat. The role of influenza A virus-induced inflammatory response in severe cases this disease widely recognized. Drug resistance and side effects chemical treatments have been observed, resulting increased interest alternative use herbal medications for prophylaxis against infection. South African medicinal plant, Rapanea melanophloeos (RM) (L.) Mez the family Myrsinaceae was selected owing to its traditional treatment several diseases such as...
Endophytes are bacteria or fungi which live inside the host plant and participate in many biological processes without causing disease other adverse effects. recognised as a rich source of secondary metabolites with potentially useful pharmacological properties. Many South African medicinal plants highly under-investigated sources endophytic microbes. In this report six were obtained from leaves, stems roots known for their traditional uses The isolated Cotyledon orbiculata L., Psychotria...
Many plants are used in traditional medicine to treat tuberculosis and other respiratory disorders Africa. The emergence of multiple drug resistance has become a major threat thus calls for an urgent need search new effective safe anti-TB agents. aim was determine the antimycobacterial activity safety acetone leaf extracts 14 plant species southern Africa pulmonary ailments. evaluated by tetrazolium violet based broth microdilution method against three fast-growing mycobacteria...
Diarrhoea, a global economically important disease burden affecting swine and, especially piglets, is commonly caused by infection with entero-toxigenic E. coli (ETEC). Adherence of ETEC to porcine intestinal epithelial cells following infection, necessary for its pathogenesis. While antimicrobials are given as therapy or feed additives prophylaxis against microbial infections, the concern over increased levels antimicrobial resistance necessitate search safe and effective alternatives in...
A series of indole-aminoquinazolines was prepared via amination the 2-aryl-4-chloroquinazolines with 7-amino-2-aryl-5-bromoindoles. It then evaluated for cytotoxicity in vitro against human lung cancer (A549), epithelial colorectal adenocarcinoma (Caco-2), hepatocellular carcinoma (C3A), breast (MCF-7), and cervical (HeLa) cells. combination on quinazoline indole moieties a 2-phenyl 2-(4-fluorophenyl) rings compound 4b; 3-chlorophenyl 4f; or two 4g, resulted significant moderate activity...
Tuberculosis (TB) caused by Mycobacterium tuberculosis remains an ongoing threat to human health. Many plant species contain antimycobacterial compounds, which may serve as template molecules for new anti‐TB drugs. The Rubiaceae family is the largest of trees in southern Africa, and preliminary evidence revealed activity several genus, motivating further studies. Leaf extracts 15 tree from were screened against pathogenic M. non‐pathogenic smegmatis, aurum bovis BCG (Bacillus...
The Rubiaceae family has played a significant role in drug discovery by providing molecules with potential use as templates for the development of therapeutic drugs. This study was designed to vitro synergistic effect six species combination known anti-TB drug. antioxidant and anti-inflammatory activity these were also evaluated investigate additional benefits antimycobacterial treatment.The checkerboard method used determine plant extracts combined rifampicin. determined...
Urinary tract infections (UTIs) caused by opportunistic pathogens are among the leading health challenges globally. Most available treatment options failing as a result of antibiotic resistance and adverse effects. Natural sources such plants may serve promising alternatives.Compounds were isolated from South African weed Chromolaena odorata through column chromatography. Purified compounds tested for antimicrobial activity using p-iodonitrotetrazolium chloride (INT) colorimetric method,...
Hypertension is the most common cardiovascular disease that affects approximately 26% of adult population, worldwide. Rutin one important flavonoids consumed in daily diet, and found many food items, vegetables, beverages. Uninephrectomy (UNX) left kidney was performed, followed by induction hypertension. The rats were randomly divided into four groups 10 rats: group 1—Sham-operated rats; 2—UNX rats, 3—UNX-L-NAME (40 mg/kg) plus rutin (100 mg/kg bwt), 4—UNX-L-NAME lisinopril (10 orally for 3...
Tuberculosis is a deadly disease caused by Mycobacterium species. The use of medicinal plants an ancient global practice for the treatment and prevention diverse ailments including tuberculosis. aim this study was to isolate characterize antimycobacterial compounds bioassay-guided fractionation acetone leaf extract Oxyanthus speciosus. A two-fold serial microdilution method used determine minimum inhibitory concentration (MIC) against mycobacteria. Cytotoxicity nitric oxide activity isolated...
A series of 2-arylbenzo[b]furan–appended 4-aminoquinazoline hybrids were prepared and evaluated for cytotoxicity in vitro against the human lung cancer (A549), colorectal adenocarcinoma (Caco-2), hepatocellular carcinoma (C3A) cervical (HeLa) cell lines. Compounds 10d 10j exhibited significant C3A Caco-2 lines induced apoptosis these Likewise, compounds 10e inhibitory activity towards epidermal growth factor receptor-tyrosine kinase phosphorylation (IC50 values 29.3 nM 31.1 nM, respectively)...
Alien invasive plants pose a huge threat to natural and semi-natural ecosystems in their introduced ranges thereby compromising ecosystem integrity. However, anecdotal empirical evidence suggests that some alien are used traditional medicine due pharmacological activities. Here, we evaluated the antimicrobial activity of 70% ethanol, dichloromethane, acetone hot water extracts four South Africa viz. Dolichandra unguis-cati, Cardiospermum grandiflorum, Chromolaena odorata Gomphrena...
Tuberculosis (TB), a disease caused by microorganisms of the Mycobacterium tuberculosis complex, infects almost one-third world's population. The TB epidemic has been further exacerbated emergence multi, extensively, and totally-drug-resistant (MDR, XDR, TDRTB) strains. An effective immune response plays crucial role in determining establishment infection. Therefore, modulation system considered as vital approach for treatment or control various immune-related diseases such TB. In this...
Tuberculosis, caused by Mycobacterium tuberculosis, is a worldwide disease affecting millions of people. The rise resistant strains, coupled with toxicity current chemotherapy, requires effective alternatives against mycobacterial infections. Some plants from the Menispermaceae family have been used to treat tuberculosis and cough related symptoms. In this study, acetone, methanol:water (4:1), dichloromethane:methanol (1:1) hot water extracts different plant parts Cissampelos owariensis,...
The growing resistance of pathogenic microorganisms to antibiotics has resulted in an increasing need worldwide for new candidate drugs combat antibiotic resistance. It is widely acknowledged that are a prolific source highly potent antibacterial, antifungal and anticancer compounds, owing their capacity producing interesting natural products [1]. Endophytes residing medicinal plants have excellent bioprospecting potential, particularly when combined with the remarkable pharmacological...
Aspergillosis is an opportunistic airborne fungal infection caused by ubiquitous saprophytic moulds of the Aspergillus genus. Infection has been documented in humans and animals, it usually occurs through inhalation unicellular spores known as conidia or, more rarely, after ingestion or wound contamination. Oral candidiasis also important sign for clinical diagnosis indicator evolution immunodeficiency among HIV carriers. Mycotic stomatitis animals Candida spp. most cases. Cryptococcosis a...