A5090336507- Malaria Research and Control
- Blood Pressure and Hypertension Studies
- Natural Antidiabetic Agents Studies
- Drug-Induced Hepatotoxicity and Protection
- Sodium Intake and Health
- Pharmaceutical Practices and Patient Outcomes
- Hormonal Regulation and Hypertension
- Computational Drug Discovery Methods
- Herbal Medicine and Trade Cooperation
- Toxin Mechanisms and Immunotoxins
- Pharmacological Effects of Natural Compounds
- Phytochemicals and Antioxidant Activities
- Mosquito-borne diseases and control
- Pharmacovigilance and Adverse Drug Reactions
- Epilepsy research and treatment
- Peroxisome Proliferator-Activated Receptors
- Pharmaceutical Economics and Policy
- Moringa oleifera research and applications
- Phytochemistry and Biological Activities
- SARS-CoV-2 and COVID-19 Research
- Medicinal Plants and Bioactive Compounds
- Pharmaceutical studies and practices
- Drug Transport and Resistance Mechanisms
- Global Maternal and Child Health
- Ophthalmology and Eye Disorders
University of Ibadan
2014-2023
University College Hospital, Ibadan
2016-2023
Adama (Israel)
2019
University College Hospital
2017
University College London
2017
Pineapple peel is a waste component of pineapple with valuable source metabolites as phytoactive compounds in ameliorating metabolic-related disorders. This study investigated the atheroprotective and neuroprotective effects extract Ananas comosus fruit (PEAC) normal diet (ND) high-fat (HFD) fed rats. Male Wistar rats were ND or HFD for 9 weeks, beginning from 6th week animals also orally treated PEAC (200 mg/kg). Memory performance was assessed using Y-maze test (YMT) novel object...
Abstract Background Malaria is a major public health concern among pregnant women in sub‐Saharan Africa. Within the region, Nigeria has highest malaria cases. This study aimed to determine prevalence and factors associated with parasitaemia at booking clinic Ibadan, Nigeria. Methods A cross‐sectional was conducted between January April 2021 University College Hospital sample of 300 participated, anaemia were diagnosed using packed cell volume Giemsa‐stained blood smears, respectively. Data...
Oxidative stress and inflammation arising from hyperglycaemia have been identified as important targets in mitigating hyperglycaemia-induced organ dysfunction diabetics. Chrysophyllum albidum fruit is commonly consumed snacks because of its beneficial effects diabetes management. This study aim to evaluate the protective mechanisms extract (CAFE) streptozotocin-induced rats involving attenuation oxidative stress, nuclear factor-kappa B (NF-κB) peroxisome proliferator-activated receptor-gamma...
Health-related quality of life (HRQOL) in hypertensive patients may be influenced by the presence and knowledge disease, beliefs associated with blood pressure (BP) control, drug utilization. The impact hypertension on HRQOL compared to normal population has not been assessed Nigeria, most populous country sub-Saharan Africa. This study compares population; effect BP control medication is also assessed.A prospective cross-sectional 713 individuals, 606 were attending University College...
The Liver is one of the organs involved in multiorgan failure that occurs sickle cell disease, pathophsiology liver disease this condition complex because interrelated multifactorial causes. dysfunction was assessed both paediatric and adult patients steady state. transaminases alkaline phosphatase were analysed by automation while coagulation studies done manually. mean (range) Alanine transaminase (ALT), Aspartate (AST) (ALP) 23.0 (2-77) IU, 48.5 (15-120) 227.5 (37-1200) IU respectively....
Abstract Background In Nigeria, declining responsiveness to artemether–lumefantrine (AL), the artemisinin-based combination therapy (ACT) of choice since 2005, has been reported. Pyronaridine–artesunate (PA) is a newer fixed-dose ACT recently prequalified by WHO for treatment uncomplicated falciparum malaria. However, PA data from Nigerian pediatric population scarce. Therefore, efficacy and safety AL using 28-day anti-malarial therapeutic study protocol in Ibadan, southwest were compared....
Hypertension remains one of the leading causes death in Nigeria. Appropriate and cost-effective treatment disease is necessary to reduce mortality. This study evaluates (i) prescription patterns quality (ii) blood pressure control (iii) cost medication among patients with hypertension uncomplicated by co-morbid diseases or compelling indications.
Aims Intensive monitoring of medical patients for adverse drug reactions (ADRs) to assess prevalence, incidence, risk factors and fatality ADRs leading hospital admission or occurring in the hospital. Methods Prospective cohort study on 1280 adult admitted wards a tertiary institution over 12 months. Patients were assessed during throughout admission; causality preventability assessed. Results Sixty‐seven (5.2%) had ADRs, 51 (3.9%) caused hospitalisation while 17(1.3%) occurred...
Background: Developing countries though faced with increasing burden of cardiovascular disease have the least contribution in articles published on research. There is a paucity report trend diseases particularly no available Nigerian female patients. The aim this study to determine and gender effect.Materials Methods: A retrospective analysis medical admission public, secondary health center over 5-year period (1997–2001) was carried out.Results: Of 2474 patients, 37.0% mean age 54.9 (14.6)...
This research work aimed at investigating the management of hypertension from statistics documented in hospital records.Data was sourced patients' case notes and these records, information obtained include blood pressure readings, drugs used, comorbidities, length treatment; parameters were used evaluating prescription pattern recent rate control hypertensive patients as indices current hypertension.The underlying hypothesis for is that a longer period evaluation should be better metric...
Most available reports on the biological activity of Adenanthera pavonina (AP) are bark or leaves and very few seeds. In particular, there no effects chromatographic fractions A. seeds hence present study aimed to evaluate antimicrobial crude extract The methanolic was fractionated all column as well were evaluated against different strains Staphylococcus aureus. (100 mg/ml) produced zones inhibition PHM 002 005 while 50 100 mg/ml hexane only 001. On other hand, ST 10-12 F exhibited at...
Statins reduce cardiovascular risk, especially in patients with hypertension due to their concomitant blood pressure reducing effects. Prescribing generic statins minimizes cost and improves access.Ascertain current prescribing of Nigeria potential savings from the increased use statins.Prospective study involving hypertensive attending University College Hospital (Ibadan, Nigeria).In total, 228 received statins. Atorvastatin was most prescribed statin, followed by simvastatin, rosuvastatin...
Pulmonary tuberculosis (PTB) is global disease affecting about one third of the world’s population with its attendant mortality and morbidity. Acute phase proteins have been used in monitoring progression infections but not relation to PTB this environment. The levels total protein, albumin, α-2- macroglobulin, transferrin, haptoglobulin were determined 23 patients 17- age / sex matched PTB-free controls using spectrophotometric immunodiffusion methods respectively. result showed that...
Hypertension and its complications are now responsible for about a quarter of emergency medical admissions in urban hospitals Nigeria. It is the commonest risk factor stroke, heart failure, chronic kidney disease, dementia. Furthermore, high blood pressure cause sudden unexpected natural death country. Regrettably, rate awareness, treatment, control abysmally low country many parts world. May Measurement Month (MMM) global initiative International Society aimed at raising awareness (BP) to...
Introduction Rational use of antimicrobial agents is necessary to prevent the emergence drug resistance. This study aims assess prescription pattern antibiotics using Anatomic Therapeutic Chemical Classification (ATCC)/Defined Daily Dose (DDD) metrics in real-world practice. Methods A retrospective audit prescribed patients admitted a tertiary hospital over 20 months. The demographics and clinical information were collected. ATCC/DDD system was used classify antibiotics. DDD per 100 bed-days...
Objectives: Malaria and oxidative stress are major health problems in the world general. The goal of study is to investigate antimalarial antioxidant activities methanol seed extract Adenanthera pavonina linn (ADP) Plasmodium berghei infected mice. Methods: Thirty five mice distributed into seven groups animals each were used this study. berghei, was inoculated Swiss albino intraperitoneally with an innoculum size 1x107 on day zero (D0). vehicle (1% DMSO), ADP (100, 200, 400, 600 800 mg/kg...