A5017291556- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Fluorine in Organic Chemistry
- Nuclear Physics and Applications
- Radioactive element chemistry and processing
- Chemical Reactions and Isotopes
- Cancer, Hypoxia, and Metabolism
- Lanthanide and Transition Metal Complexes
- Radioactive Decay and Measurement Techniques
- Boron Compounds in Chemistry
- Particle accelerators and beam dynamics
- Chemical Synthesis and Analysis
- Nuclear physics research studies
- Glioma Diagnosis and Treatment
- Neurotransmitter Receptor Influence on Behavior
- Adenosine and Purinergic Signaling
- Muon and positron interactions and applications
- Amino Acid Enzymes and Metabolism
- Radioactive contamination and transfer
- Oxidative Organic Chemistry Reactions
- Receptor Mechanisms and Signaling
- Chemical Synthesis and Characterization
- Neuroscience and Neuropharmacology Research
- Chemical Synthesis and Reactions
- Radioactivity and Radon Measurements
Hasselt University
2024
Forschungszentrum Jülich
2012-2022
Ernst Ruska Centre
1985-2019
Stadtwerke Jülich (Germany)
1990-2019
University of Cologne
2007-2015
Brain (Germany)
2007
University of Pennsylvania
2004
Essen University Hospital
1994-1996
Max Planck Society
1988
The dopaminergic mechanisms that control reward-motivated behavior are the subject of intense study, but it is yet unclear how, in humans, neural activity mesolimbic reward-circuitry and its functional neuroimaging correlates related to dopamine release. To address this question, we obtained magnetic resonance imaging (fMRI) measures reward-related [(11)C]raclopride positron emission tomography release same human participants, while they performed a delayed monetary incentive task. Across...
Unravelling the factors determining allocation of carbon to various plant organs is one great challenges modern biology. Studying under close natural conditions requires non-invasive methods, which are now becoming available for measuring plants on a par with those developed humans. By combining magnetic resonance imaging (MRI) and positron emission tomography (PET), we investigated three contrasting root/shoot systems growing in sand or soil, respect their structures, transport routes...
Diaryliodonium salts containing the 2-thienyl group as an example of electron-rich heteroaromatic moiety proved to be very potent precursors for nucleophilic, regioselective no-carrier-added (nca) radiofluorination various arenes. It even allowed nucleophilic introduction nca [18F]fluoride into arene compounds in one step. The influences substitution pattern, counteranions, and different reaction conditions were studied. Effects counterions could explained by influence solvent on ion pair...
It is currently hypothesized that adenosine involved in the induction of sleep after prolonged wakefulness. This effect partially reversed by application caffeine, which a nonselective blocker receptors. Here, we report most abundant and highly concentrated A 1 subtype cerebral receptors upregulated 24 h deprivation. We used selective receptor (A AR) radioligand [ 18 F]CPFPX ([ F]8-cyclopentyl-3-(3-fluoropropyl)-1-propylxanthine) quantitative positron emission tomography to assess ARs before...
Iodonium ylide precursors of electron rich arenes, <italic>i.e.</italic> the NET and SERT ligands 4-((3- 4-fluorophenoxy)phenylmethyl)piperidine, served as model compounds for direct substitution with n.c.a. [<sup>18</sup>F]fluoride.
Abstract This systematic study describes the preparation of bifunctional n.c.a. 18 F‐fluoroalkanes using amino‐polyether (APE) supported nucleophilic substitution. With APE (Kryptofix ® 2.2.2.) potassium carbonate complex in acetonitrile F − is introduced into disubstituted alkanes ( X(CH 2 ) n X, = 1–3, X Br, OMes, OTos) high yields within 10–15 min. The substitution yield increases sequence leaving groups Br < OMes OTos and with increasing alkyl chain length. At substrate concentrations...
Summary The metabotrophic subtype 5 glutamate receptor ( mG luR5) plays a critical role in synaptic plasticity besides its involvement numerous neurological disorders, such as depression. As luR5 availability humans is altered sleep deprivation, we hypothesized that underlies circadian variation. To investigate whether potential changes measured density randomized fashion at six different daytimes 11 adult Sprague–Dawley rats. was quantified by positron emission tomography PET ) using the...
The <sup>18</sup>F-labeled aromatic amino acid 6-fluoro-3,4-dihydroxy-l-phenylalanine (6-<sup>18</sup>F-fluoro-l-DOPA) is widely used as a radiopharmaceutical in neurologic and oncologic PET. In this study, novel approach to the preparation of carrier-added (CA) 6-<sup>18</sup>F-fluoro-l-DOPA 3 radiosynthesis steps was developed evaluated; approach, direct nucleophilic <sup>18</sup>F fluorination protected derivative used. method currently for routine by electrophilic labeling limited...
Summary The excitation function of the 68 Zn( p , 2 ) 67 Cu reaction was measured radiochemically up to a proton energy 71 MeV obtain accurate data for production therapy related β − -emitting radioisotope ( T 1/2 = 61.9 h). Investigations were also made on n and 3 reactions Zn. experimental cross sections Cu, Ga 66 compared with published theoretical predictions based hybrid-precompound model ALICE-IPPE. Thick target yields 78.3 h) 9.4 calculated. Production is feasible only at energies...