A5079703139- Peptidase Inhibition and Analysis
- Radiopharmaceutical Chemistry and Applications
- Neuropeptides and Animal Physiology
- Chemical Synthesis and Analysis
- Medical Imaging Techniques and Applications
- Historical Geopolitical and Social Dynamics
- Receptor Mechanisms and Signaling
- Pharmacological Receptor Mechanisms and Effects
- Inflammatory mediators and NSAID effects
- Nanoplatforms for cancer theranostics
- Click Chemistry and Applications
- Chemical Reactions and Isotopes
- Cell Adhesion Molecules Research
- Prostate Cancer Treatment and Research
- Peroxisome Proliferator-Activated Receptors
- Monoclonal and Polyclonal Antibodies Research
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Drug Transport and Resistance Mechanisms
- Glioma Diagnosis and Treatment
- Coffee research and impacts
- Diabetes Treatment and Management
- Aluminum toxicity and tolerance in plants and animals
- European Law and Migration
- Hypothalamic control of reproductive hormones
University of Debrecen
2014-2024
University of Antwerp
2003-2020
Antwerp University Hospital
2019-2020
Corvinus University of Budapest
2011
Hungarian Academy of Sciences
1998-2008
Institute of Biochemistry
1999-2008
Centro de Investigación Biomédica en Red
2008
Medical University of Vienna
2008
Wilhelminen Hospital
2008
Johns Hopkins University
2008
Porcine bone marrow-derived mesenchymal stem cells (MSCs) were stably transfected with a lentiviral vector for transgene expression of the trifusion protein renilla luciferase, red fluorescent and herpes simplex truncated thymidine kinase (LV-RL-RFP-tTK; positron emission tomography [PET] reporter gene) in vivo noninvasive tracking intramyocardially delivered MSC fate.A closed-chest, reperfused myocardial infarction was created farm pigs. Sixteen days after infarction, LV-RL-RFP-tTK-MSCs...
The feasibility of the fluoro-olefin function as a peptidomimetic group in inhibitors for dipeptidyl peptidase IV and II (DPP DPP II) is investigated by evaluation N-substituted Gly-Psi[CF=C]pyrrolidines, Gly-Psi[CF=C]piperidines, Gly-Psi[CF=C](2-cyano)pyrrolidines. Of this later class, (Z)- (E)-fluoro-olefin analogues were prepared chemical stability comparison with parent amide was checked. Most these compounds exhibited strong binding preference toward IC(50) values low micromolar range,...
Synaptic pathology is associated with several brain disorders, thus positron emission tomography (PET) imaging of synaptic vesicle glycoprotein 2A (SV2A) using the radioligand [ 11 C]UCB-J may provide a tool to measure alterations. Given pivotal role mouse models in understanding neuropsychiatric and neurodegenerative this study aims validate characterize mice. We performed blocking verify specificity radiotracer SV2A, examined kinetic an image-derived input function (IDIF) for...
The δ-opioid antagonist H-Tyr-Tic-Phe-Phe-OH (TIPP-OH) or its C-terminal amide analogue was systematically modified topologically by substitution of each amino acid residue all stereoisomers the corresponding β-methyl acid. potency and selectivity (δ- vs μ- κ-opioid receptor) were evaluated radioreceptor binding assays. Agonist assayed in mouse vas deferens guinea pig ileum. In TIPP analogues containing l-β-methyl acids influence on δ-receptor affinity δ-antagonist is limited,...
Owing to the high chemoselectivity between an aminooxy function and a carbonyl group, oxime ligation is one of most preferred procedures for preparation peptide conjugates. However, sensitivity (aminooxy)acetylated peptides ketones aldehydes makes their synthesis storage difficult. In our study, we established efficient (aminooxy)acetylated-somatostatin derivative in presence free (aminooxy)acetic acid, which was used as 'carbonyl capture' reagent final cleavage step. This compound further...
The purpose of this study was to develop a folate receptor-targeted 68Ga-labeled agent for the detection cancer cells in mouse models ovarian by dual positron-emission tomography (PET) and magnetic resonance imaging (MRI). Moreover, we aimed controlled biopolymer-based chemistry that enables linking metal-binding (here Ga-68) chelators.The nanoparticle (NP) created self-assembling folic acid-modified polyglutamic acid chelator-modified chitosan followed radiolabeling with 68Ga (III) ions...
In order to compare the coordination properties of 1,4,7-triazacyclononane (tacn) derivatives bearing varying numbers phosphinic/carboxylic acid pendant groups towards 68Ga, 1,4,7-triazacyclononane-7-acetic-1,4-bis(methylenephosphinic) (NOPA) and 1,4,7- triazacyclononane-4,7-diacetic-1-[methylene(2-carboxyethyl)phosphinic] (NO2AP) were synthesized using Mannich reactions with trivalent or pentavalent forms H-phosphinic acids as phosphorus components. Stepwise protonation constants logK1–3...
Background/Aim: Since the use of anaesthetics has drawback altering radiotracer distribution, preclinical positron emission tomography (PET) imaging findings anaesthetised animals must be carefully handled. This study aimed at assessing cerebral [<sup>18</sup>F]F-FDG uptake pattern in healthy Wistar rats under four different anaesthesia protocols using microPET/magnetic resonance (MRI) examinations. Materials and Methods: Post-injection 15±1.2 MBq [<sup>18</sup>F]F-FDG, either while awake or...
Background: To better understand ischaemia-related molecular alterations, temporal changes in angiogenic Aminopeptidase N (APN/CD13) expression and glucose metabolism were assessed with PET using a rat model of peripheral arterial disease (PAD). Methods: The mechanical occlusion the base left hindlimb triggered tourniquet was applied to establish ischaemia/reperfusion injury Fischer-344 rats. 2-[18F]FDG [68Ga]Ga-NOTA-c(NGR) imaging performed 1, 3, 5, 7, 10 days post-ischaemia induction...
Since acute myeloid leukemias still represent the most aggressive type of adult leukemias, profound understanding disease pathology is paramount importance for diagnostic and therapeutic purposes. Hence, this study aimed to explore real-time fate with establishment an experimental myelomonoblastic leukemia (My1/De) rat model using preclinical positron emission tomography (PET) whole-body autoradiography.
Purpose: The most aggressive form of skin cancer is the malignant melanoma.Because its high metastatic potential early detection primary melanoma tumors and metastases using non-invasive PET imaging determines outcome disease.Previous studies have already shown that benzamide derivatives, such as procainamide (PCA) specifically bind to melanin pigment.The aim this study was synthesize investigate specificity novel 68 Ga-labeled NODAGA-PCA molecule in vitro vivo techniques.Methods:...
The aminopeptidase N (APN/CD13) receptor plays an important role in the neoangiogenic process and metastatic tumor cell invasion. Clinical preclinical studies reported that bestatin actinonin are cytotoxic to APN/CD13-positive tumors metastases due their APN/CD13-specific inhibitor properties. Our previous have already shown 68Ga-labeled NGR peptides bind specifically APN/CD13 expressing cells. specificity of 68Ga-NGR radiopharmaceuticals enables following efficacy antiangiogenic therapy...
We aimed to evaluate [3-(6-methyl-pyridin-2-ylethynyl)-cyclohex-2-enone-0-11C-methyloxime] ([11C]ABP688) small animal positron emission tomography (μPET) as a biomarker visualize possible longitudinal changes in metabotropic glutamate receptor 5 (mGluR5) availability the brain of SAP90/PSD-95 associated protein 3 (Sapap3) knockout (ko) mice, showing obsessive compulsive disorder (OCD)-like behavior.Alongside assessment grooming, we performed [11C]ABP688 μPET/CT imaging wildtype (wt; n=10)...
Recently, morphological impairments have been detected in the brain of a triple-hit rat schizophrenia model (Wisket), and delayed depressive effects caffeine treatment both control Wisket animals also shown. The aims this study were to determine basal caffeine-induced acute (30 min) (24 h) changes cerebral 18fluorodeoxyglucose (18F-FDG) uptake by positron emission tomography (PET) rats. No significant differences identified whole-brain metabolism between two groups, was not modified acutely...
Prostaglandin E2 (PGE2) molecule and its receptors play an important role in the development of malignancies metastases therefore PGE2 may a crucial diagnosis new therapeutic target field radionuclide therapy PGE2-positive tumors. form complexes with RAMEB (randomly-methylated-beta-cyclodextrin) high affinity aim this present study was to synthesize PGE2-specific DOTAGA-RAMEB, which can be labeled diagnostic isotopes also binds DOTAGA-RAMEB 68Ga 205/206Bi radionuclides their radiochemical...