A5026188761- Liver Disease Diagnosis and Treatment
- GDF15 and Related Biomarkers
- Nutrition and Health in Aging
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Lipid metabolism and disorders
- Nuclear Receptors and Signaling
- Macrophage Migration Inhibitory Factor
- Liver Disease and Transplantation
- Diabetes and associated disorders
- Endoplasmic Reticulum Stress and Disease
- COVID-19 Clinical Research Studies
- Adipose Tissue and Metabolism
- Thyroid Disorders and Treatments
- Biomedical Ethics and Regulation
- Pharmaceutical Economics and Policy
- Sexual Differentiation and Disorders
- Thyroid and Parathyroid Surgery
- Ion Transport and Channel Regulation
- Caveolin-1 and cellular processes
- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatitis Pathology and Treatment
- Genetic Syndromes and Imprinting
- Congenital Ear and Nasal Anomalies
- Liver Diseases and Immunity
Harvard University
2022-2024
Beth Israel Deaconess Medical Center
2022-2024
Universidad del Rosario
2020-2023
Institute of Cardiology
2022-2023
Abstract Background and Aims Thyroid axis is currently under investigation as a therapeutic target in metabolic dysfunction‐associated steatotic liver disease (MASLD). function was examined herein the full spectrum of disease. Methods Subjects were recruited had biopsies two Gastroenterology‐Hepatology Clinics (Greece Australia) one Bariatric‐Metabolic Surgery Clinic (Italy). The main working sample n = 677 subjects with MASLD after excluding abnormal free thyroxine levels. Participants...
Abstract Mitochondrial-secreted growth differentiation factor-15 (GDF-15) promotes weight loss in animals. Its effects humans remain unclear, due to limited research and potential measurement interference from the H202D-variant. Our post-hoc analysis investigates total (irrespective of genetic variants) H-specific GDF-15 (detected only H202D-variant absence) under acute chronic energy deprivation, examining interaction with leptin (energy homeostasis regulator) biologic activity modulation...
Abstract Background Growth differentiation factor 15 (GDF15) is a mitokine, the role of which, total or H-specific, in modulating energy metabolism and homeostasis obesity-related diseases, such as metabolic dysfunction associated steatotic liver disease (MASLD), has not been fully elucidated adult humans. We aimed to investigate fasting stimulated levels GDF15, glucose-dependent insulinotropic polypeptide (GIP) C-peptide, two physiology interventional studies: one focusing on obesity, other...
Primary hyperparathyroidism is a disease with multisystemic and heterogeneous manifestations, characterized by underlying high parathormone concentrations. Despite neuropsychiatric involvement being one of the psychosis rare. This case 68-year-old female 10-day clinical course anorexia, mutism, dysphagia, constipation, weight loss. The patient had disorganized speech associated paranoid delusions. Prior to this visit, was recently diagnosed mixed anxiety-depressive disorder. For reason,...
Coronavirus 19 disease (COVID-19) presents a highly variable clinical presentation and course, ranging from asymptomatic patients to rapidly progressive, fatal pneumonia. The known heterogeneous outcomes can affect both previously healthy those with significant comorbidities, who develop courses possibly more multisystemic compromise. Likewise, the development of thrombotic phenomena during acute course is associated complications that worsen patient prognosis. We present case report...
Diabetic ketoacidosis is a life-threatening complication associated with type 1 diabetes (T1D). Recent evidence suggests that SARS-CoV-2 could trigger diabetic in susceptibility and previous insulitis; however, the data on SARS-CoV-2-infected patients as their are still limited. We report 13-year-old Latinamerican male symptoms laboratory tests diagnostic of positive reverse transcription polymerase chain reaction, who required mild COVID-19 care management, fluid resuscitation, insulin...
Familial hyperchylomicronemia syndrome is a monogenic autosomal recessive disorder that causes severe and refractory hypertriglyceridemia. This uncommon condition challenging to diagnose treat can lead comorbidities such as acute pancreatitis. Although treatment options are limited in the pediatric population, strict diets treatments approved for other dyslipidemias may be implemented familial syndrome, given lack of pharmacological interventions available. We report 14-year-old female...
Myxedema coma is an emergency that develops from non-diagnosed or severe hypothyroidism and requires early recognition management. Cardiac manifestations are uncommon pose a challenge in the of myxedema coma. We present case 76-year-old male with history thyroidectomy secondary to follicular carcinoma, who presented dyspnea, generalized edema, drowsiness, disorientation, memory loss, episodic tonic-clonic seizures. Antiepileptic diuretic treatment for seizures heart failure exacerbation did...