A5103005592- Hearing, Cochlea, Tinnitus, Genetics
- Vestibular and auditory disorders
- Cancer-related molecular mechanisms research
- Hearing Loss and Rehabilitation
- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- Olfactory and Sensory Function Studies
- RNA regulation and disease
- Circular RNAs in diseases
- Immune Cell Function and Interaction
- Microplastics and Plastic Pollution
- Aldose Reductase and Taurine
- Toxic Organic Pollutants Impact
- MicroRNA in disease regulation
- Ear Surgery and Otitis Media
- Atherosclerosis and Cardiovascular Diseases
- Membrane Separation Technologies
- Curcumin's Biomedical Applications
- Extracellular vesicles in disease
- Hydrogels: synthesis, properties, applications
- Smoking Behavior and Cessation
- Biological and pharmacological studies of plants
- Flame retardant materials and properties
- Complement system in diseases
- Silicone and Siloxane Chemistry
Pusan National University
2023-2024
Seoul National University Hospital
2022-2023
Jeonbuk National University
2021-2022
CHA University
2020-2022
CHA Bundang Medical Center
2021-2022
Ajou University
2022
Korea Testing Laboratory
2019-2020
Brandeis University
2019
Wonkwang University
2011-2014
Korean Society of Ginseng
2012
Various pollutants of different sizes are directly (e.g., water-borne diseases) and indirectly accumulation via trophic transfer) threatening our water health safety. To cope with this matter, multifaceted approaches required for advanced wastewater treatment more efficiently. Wastewater using mixed matrix membranes (MMMs) could provide an excellent alternative since it play two roles in pollutant removal by covering adsorption size exclusion contaminants simultaneously. This paper provides...
Particulate matter (PM) is a harmful air pollutant associated with respiratory and cardiovascular diseases, but its effects on adaptive immunity are poorly understood. This study investigates the role of NRF2 in T cells mediating immune pulmonary responses to long-term PM exposure, highlighting impact inhalation toxicity. To establish mouse model lung injury induced by C57BL/6 mice were intranasally administered 20 μg/kg PM10 or PM2.5 daily for 16 weeks. Lung parameters analyzed...
We report a gold nanoparticle (AuNP)-based fluorescence quenching system via metal coordination for the simple assay of protease activity. Carboxy AuNPs (5 nm in core diameter) functioned as both quenchers and chelators without requiring further modification with multidentate ligands; therefore, they were strongly associated hexahistidine regions dye-tethered peptides presence Ni(II) ions, leading to notable over varying molar ratios dye AuNP. Upon addition matrix metalloproteinase-7...
Abstract Background Nanotechnology is indispensable to many different applications. Although nanoparticles have been widely used in, for example, cosmetics, sunscreen, food packaging, and medications, they may pose human safety risks associated with nanotoxicity. Thus, toxicity testing of essential assess the relative health consumer exposure. Methods In this study, we identified NOAEL (no observed adverse effect level) agglomerated/aggregated TiO 2 P25 (approximately 180 nm) administered at...
Previous studies have described the effects of zingerone (ZO) on cisplatin (CXP)-induced injury to kidneys, liver, and other organs but not cochlea. This study aimed investigate ZO CXP-induced ototoxicity. Eight-week-old Sprague–Dawley rats were used divided into a control group, CXP + group. Rats in group received 5 mg/kg/day intraperitoneally for five days. days 50 seven Auditory brainstem response thresholds (ABRTs) measured before (day 0) after 10) drug administration. Cochlear histology...
Previous preclinical studies have demonstrated the otoprotective effects of resveratrol (RV) at low doses. This study aimed to investigate dose-dependent RV in rats with cisplatin (CXP)-induced hearing loss. Sprague-Dawley (8-weeks old) were divided into six treatment groups (n = 12/group) and treated as follows: control, 0.5 mg/kg RV, 50 CXP, + CXP), CXP groups. (3 mg/kg) was intraperitoneally injected for 5 days. (0.5 or 10 days from first day administration. Auditory brainstem response...
Hyperactivated airway mucosa cells overproduce mucin and cause severe breathing complications. Here, we aimed to identify the effects of saponins derived from Panax ginseng on inflammation overproduction. NCI–H292 were pre-incubated with 16 P. ginseng, overproduction was induced by treatment phorbol 12-myristate 13-acetate (PMA). Mucin protein MUC5AC quantified enzyme-linked immunosorbent assay, mRNA levels analyzed using quantitative polymerase chain reaction (qPCR). Moreover, performed a...
Wild ginseng is known to contain additional physiologically and pharmacologically active substances than common ginseng. The utilization of this herb can be maximized by altering its composition via tissue culture generating adventitious roots. We enriched the content specific ginsenosides investigated their role in ameliorating memory impairment. Cultured wild root was subjected extraction, steaming, fermentation using Pediococcus pentosaceus HLJG0702 enhance levels Rg5 /Rk1. analysis...
Exposure to particulate emissions from printer and cigarette smoke affects the structure function of mitochondria, which may account for pathogenesis respiratory diseases. The addition charge pollutant aerosols increase toxicity by their deposition in lower tract. mitochondrial damage lung asthmatic mice was assessed examining levels reactive oxygen species (ROS), lipid peroxides, reduced glutathione, activities isocitrate dehydrogenase, α-ketoglutarate succinate malate complexes I IV,...
Edema is a symptom that results from the abnormal accumulation of fluid in body. The cause edema related to level aquaporin (AQP)2 protein expression, which regulates reabsorption water kidney. caused by overexpression AQP2 when concentration Na(+) blood increases. rhizome Atractylodes macrocephala has been used traditional oriental medicine as diuretic drug; however, mechanism responsible for effect aqueous extract A. rhizomes (AAMs) not yet identified. We examined AAM on regulation...
Sensorineural hearing loss is one of the most common inherited sensory disorders. Functional classifications deafness genes have shed light on genotype- and mechanism-based pharmacological approaches gene therapy strategies. In this study, we characterized clinical phenotypes genotypes non-syndromic caused by transcription factor (TF) variants, functional genetic loss. Of 1280 probands whose genomic DNA was subjected to molecular testing, TF were responsible for in 2.6%. Thirty-three...
Cytotoxic T lymphocytes (CTLs) play a crucial role in cancer rejection. However, CTLs encounter dysfunction and exhaustion the immunosuppressive tumor microenvironment (TME). Although reactive oxygen species (ROS)-rich TME attenuates CTL function, underlying molecular mechanism remains poorly understood. The nuclear factor erythroid 2-related 2 (Nrf2) is ROS-responsible implicated increasing susceptibility to progression. Therefore, we examined how Nrf2 involved anti-tumor responses of CD8
The effect of statins on aminoglycoside-induced ototoxicity is controversial. This study aimed to explore the role pravastatin (PV) in kanamycin-induced hearing loss rats. Adult rats were intraperitoneally treated with 20 mg/kg/day kanamycin (KM) for 10 days. In PV- and PV + KM-treated rats, 25 was administered 5 auditory brainstem response (ABR) thresholds measured before after drug treatment using a smartEP system at 4, 8, 16, 32 kHz. Cochlear changes poly ADP-ribose (PAR) polymerase...
Abstract Background This study aimed to investigate the changes in molecules related perineuronal nets (PNNs) and synaptic transporters primary auditory cortices of rats with noise-induced hearing loss. Female Sprague–Dawley at postnatal day 7 were divided into noise control groups. Four hours 115 dB SPL white was delivered for 10 days group. Thirty after exposure, cortex inferior colliculus harvested. The expression levels vesicular glutamatergic transporter (VGLUT)1, VGLUT2, GABA (VGAT),...
ABSTRACT Neuronal extracellular vesicles (EVs) play important roles in intercellular communication and pathogenic protein propagation neurological disease. However, it remains unclear how cargoes are selectively packaged into neuronal EVs. Here, we show that loss of the endosomal retromer complex leads to accumulation EV Amyloid Precursor Protein (APP) Synaptotagmin-4 (Syt4) at Drosophila motor neuron presynaptic terminals, resulting increased release these By systematically exploring known...
Several recent preclinical studies have reported that dynamic changes in miRNA expression contribute to hearing function. This study aims investigate the cochlear nuclei (CN) of rats following chronic noise exposure. Eight-week-old (n = 14) were exposed for 4 weeks. The control raised under identical conditions without noise. Two months after exposure, auditory brainstem response (ABR) was examined, and cochlea CN harvested. In CN, levels arc, neurocan, brevican measured 6 per group)....