Karīna Goluba

ORCID: 0000-0002-3863-7934
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About
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Research Areas
  • 3D Printing in Biomedical Research
  • Malaria Research and Control
  • Hereditary Neurological Disorders
  • Microfluidic and Capillary Electrophoresis Applications
  • Natural product bioactivities and synthesis
  • Phytochemistry and Biological Activities
  • Pediatric Pain Management Techniques
  • Ubiquitin and proteasome pathways
  • thermodynamics and calorimetric analyses
  • Diet and metabolism studies
  • Cancer, Hypoxia, and Metabolism
  • Cancer Cells and Metastasis
  • Calpain Protease Function and Regulation
  • Innovative Microfluidic and Catalytic Techniques Innovation
  • Computational Drug Discovery Methods
  • Essential Oils and Antimicrobial Activity
  • Gastrointestinal motility and disorders

University of Latvia
2022-2024

The aim of the study was to obtain untreated and treated betulin colloidal particles assess their effect on viability, morphology, proliferation cytokine secretion human dermal fibroblasts. To improve bioavailability, treatment performed by an antisolvent precipitation technique. average particle size after in aqueous dispersion decreased from 552.9 ± 11.3 278.2 1.6 nm. Treated showed no cytotoxicity up a concentration 400 µg·mL-1 colorimetric tetrazolium salt viability test (CCK-8)....

10.3390/plants12173088 article EN cc-by Plants 2023-08-28

Creating a physiologically relevant shear stress in organ-on-a-chip (OOC) devices requires careful tailoring of microfluidic flow parameters. It is currently fairly common to use simple approximation assuming constant viscosity, even for serum-based media. Here, we show that popular nutrient solution (Dulbecco's Modified Eagle Medium supplemented with Fetal Bovine Serum) more complex treatment (i.e., non-Newtonian fluid), observed values significantly greater than reported literature. We...

10.48550/arxiv.2409.13650 preprint EN arXiv (Cornell University) 2024-09-20
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