A5072757772- Animal Disease Management and Epidemiology
- Viral Infections and Immunology Research
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- interferon and immune responses
- Viral Infections and Vectors
- Immune Response and Inflammation
- Vector-Borne Animal Diseases
- Parasitic Infections and Diagnostics
- Inflammasome and immune disorders
- Drilling and Well Engineering
- Parasitic infections in humans and animals
- Virology and Viral Diseases
- T-cell and Retrovirus Studies
- Viral Infections and Outbreaks Research
- Lipid metabolism and biosynthesis
- Bacteriophages and microbial interactions
- Toxin Mechanisms and Immunotoxins
- Hydraulic Fracturing and Reservoir Analysis
- RNA and protein synthesis mechanisms
- Parvovirus B19 Infection Studies
- Veterinary medicine and infectious diseases
- Kawasaki Disease and Coronary Complications
- Endoplasmic Reticulum Stress and Disease
- Metaheuristic Optimization Algorithms Research
Lanzhou Veterinary Research Institute
2014-2025
Chinese Academy of Agricultural Sciences
2014-2025
Lanzhou University
2023-2025
China University of Petroleum, Beijing
2021-2022
Xinjiang Medical University
2020
Xi'an Jiaotong University
2011
Peste des petits ruminants virus (PPRV) is the etiological agent of peste ruminants, causing acute immunosuppression in its natural hosts. However, molecular mechanisms by which PPRV antagonizes host immune responses have not been fully characterized. In particular, how suppresses activation RIG-I-like receptor (RLR) pathway has yet to be clarified. this study, we demonstrated that infection significantly RLR and type I interferon (IFN) production identified N protein as an extremely...
Adjuvants are crucial agents that enhance the immunogenicity of vaccines, with QS-21 being particularly noteworthy for its potent immunostimulatory properties. QS-21, a saponin-based vaccine adjuvant isolated from bark Quillaja saponaria, has garnered significant attention. However, application as is limited due to scarcity, complex chemical synthesis, and inherent toxicity. This study aims develop analogues simplified structures, enhanced immunogenicity, reduced Our research findings...
Senecavirus A (SVA) infection induces inflammation in animals, such as fever, diarrhea, vesicles and erosions, even death. The inflammatory cytokine interleukin-1β (IL-1β) plays a pivotal role responses to combat microbes. Although SVA can produce clinical symptoms, the modulation of IL-1β production by remains unknown at present. Here, both vitro vivo, robustly induced macrophages pigs. Infection performed NOD-, LRR-, pyrin domain-containing three (NLRP3) knockdown cells indicated that...
Peste des petits ruminants virus (PPRV) is a Morbillivirus that causes highly contagious and severe disease in various ruminants. PPRV infection leads to inhibition of host antiviral immune response. Our previous study demonstrated V protein blocks IFN response by targeting STAT proteins. In the current study, we identified phosphoprotein (P) as novel antagonistic factor counteract innate P significantly suppressed RIG-I-like receptor pathway signaling impaired IFN-β ISGs expression...
The tapeworm Taenia solium is an important human zoonotic parasite that causes great economic loss and also endangers public health. At present, effective vaccine will prevent infection chemotherapy without any side effect remains to be developed. In this study, codon usage patterns in the T. genome were examined through 8,484 protein-coding genes. Neutrality analysis showed had a narrow GC distribution, significant correlation was observed between GC12 GC3. Examination of NC (ENC vs...
FMDV is a pathogen that causes one of the world’s most destructive and highly contagious animal diseases. The 3A protein plays critical role in viral replication host range.
Abstract Foot-and-mouth disease virus (FMDV) is the causative agent of foot-and-mouth disease, one most highly infectious animal viruses throughout world. The JAK-STAT signaling pathway a conserved for IFN-β–induced antiviral gene expression. Previous studies have shown that FMDV can strongly suppress innate immune response. Moreover, although STAT1 and STAT2 (STAT1/2) been well established in signaling–induced expression, whether proteins inhibit remains poorly understood. In this study, we...
The adjuvant effects of Lactobacillus acidophilus on DNA vaccination are not fully understood. It has been hypothesized that swine-derived SW1 (LASW1) could function as an immune to enhance antigen-specific responses after foot-and-mouth disease (FMD) in mice. To evaluate the effect oral LASW1 response a vaccine (pRC/CMV-vp1) harboring FMD VP1 gene, anti-FMDV antibody and its isotypes, T-cell proliferation, cytokine detection were investigated. results showed was able FMDV-specific levels...
Abstract LIMA1 is a LIM domain and Actin binding 1 protein that acts as skeleton to promote cholesterol absorption, which makes it an ideal target for interfering with lipid metabolism. However, the detailed regulation of remains unclear. Here, we identified ring finger 40 (RNF40), E3 ubiquitin ligase previously known epigenetic modifier increase H2B ubiquitination, mediated ubiquitination thereby promoted its degradation in proteasome-dependent manner. Fraction studies revealed 1–166aa...
African swine fever (ASF) is a highly contagious and hemorrhagic disease caused by infection with the virus (ASFV), resulting in mortality rate of up to 100%. Currently, there are no effective treatments commercially available vaccines for ASF. Therefore, it crucial identify biochemicals derived from host cells that can impede ASFV replication, aim preventing controlling The an acellular organism promotes self-replication hijacking metabolic machinery biochemical resources cells....
ABSTRACT African swine fever (ASF) is a devastating disease caused by the virus (ASFV) that adversely affects pig industry. The spleen main target organ of ASFV; however, function metabolites in during ASFV infection yet to be investigated. To define metabolic changes after infection, untargeted and targeted metabolomics analyses spleens from ASFV-infected pigs were conducted. Untargeted analysis revealed 540 with significant differential levels. Kyoto Encyclopedia Genes Genomes pathway...
Abstract In the progression of diabetes, sustained glucagon secretion facilitates glucose production. Despite its significance, no treatments currently target this vital parameter. We employed promoter sequence thioredoxin-interacting protein (TXNIP) as a screening target, evaluated our in-house chemical library, and subsequently undertook high-throughput optimization via various medicinal chemistry techniques. Our efforts led to identification SKL-1223, an orally administered, non-toxic...
Southern Africa Territories 2 (SAT2) foot-and-mouth disease (FMD) has crossed long-standing regional boundaries in recent years and entered the Middle East. However, existing vaccines offer poor cross-protection against circulating strains field. Therefore, there is an urgent need for alternative design approach anticipation of a pandemic SAT2 Foot-and-mouth virus (FMDV). The porcine parvovirus (PPV) VP2 protein can embed exogenous epitopes into four loops on its surface, assemble virus-like...
Bovine viral diarrhea virus (BVDV) is a pathogen that affects ruminants worldwide and one of the most economically important diseases cattle.Although BVDV infections have been increasingly reported in China, pathogenesis genetic characteristics these isolates not thoroughly investigated.Here, we report identification characterization novel isolate, designated LC, which was isolated from feces cattle with diarrhea.The complete genome isolate LC 12.271 nucleotides contained 5'-UTR 389...
Foot-and-mouth disease virus (FMDV) infection causes inflammatory clinical symptoms, such as high fever and vesicular lesions, even death of animals. Interleukin-1β (IL-1β) is an cytokine that plays essential role in responses against viral infection. The viruses have developed multiple strategies to induce the responses, including regulation IL-1β production. However, molecular mechanism underlying induction by FMDV remains not fully understood. Here, we found robustly induced production...
Almost all Echinococcus multilocularis ( Em ) infections occur in the liver of intermediate host, causing a lethal zoonotic helminthic disease, alveolar echinococcosis (AE). However, long non-coding RNAs (lncRNAs) expression profiles host and potential regulatory function lncRNA during infection are poorly understood. In this study, lncRNAs mRNAs mice at different time points after were explored by microarray. Thirty-one differentially expressed (DEMs) 68 (DELs) found continuously...
Wellbore instability is a frequent problem of shale drilling. Accurate calculation surge-swab pressures in tripping processes essential for wellbore pressure management to maintain stability. However, cutting plugs formed horizontal wells have not been considered previous models. In this paper, model considering the effect established both open pipe string and closed conditions; model, osmotic plug analyzed. The reduction porosity due hydration expansion dispersion considered, ultimately...
Porcine reproductive and respitatory syndrome virus (PRRSV) is a recently emerged pathogen severely affects swine populations worldwide. The replication of PRRSV tightly controlled by viral gene expression the codon usage translation initiation region within each could potentially regulate rate. Therefore, better understanding pattern would shed light on regulation expression.In this study, in whole coding sequence was compared ORF1a ORFs2-7. To investigate potential role affecting rate, we...
Abstract Background: Monocytes are significant players in the detection of invading pathogens, particularly pathogen defense. Bovine Viral Diarrhea Virus (BVDV) can cause a persistent infection and immune suppression if animals infected with an non-cytopathic (ncp) biotype. However, its exact role ncp BVDV1-infected bovine monocytes remains poorly understood. Results: RNA sequencing (RNA-seq) was used to investigate effect BVDV1 on transcriptional profile monocytes. Compared non-infected...