A5100620047- Lung Cancer Research Studies
- Advanced Breast Cancer Therapies
- Lung Cancer Treatments and Mutations
- Gastrointestinal Tumor Research and Treatment
- Lung Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Gastric Cancer Management and Outcomes
- Sarcoma Diagnosis and Treatment
- Endometriosis Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Neuroendocrine Tumor Research Advances
- Ovarian cancer diagnosis and treatment
- Chemokine receptors and signaling
- interferon and immune responses
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Lymphoma Diagnosis and Treatment
- Autoimmune Bullous Skin Diseases
- Reproductive System and Pregnancy
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Ferroptosis and cancer prognosis
- Natural Antidiabetic Agents Studies
- Toxin Mechanisms and Immunotoxins
Xinjiang Academy of Agricultural and Reclamation Science
2020-2025
Lanzhou Veterinary Research Institute
2024
Chinese Academy of Agricultural Sciences
2024
Lanzhou University
2024
National Clinical Research Center for Digestive Diseases
2024
Xiamen Medical College
2022-2024
Chengdu Fifth People's Hospital
2024
First Affiliated Hospital of Hebei Medical University
2023-2024
Hebei Medical University
2023-2024
Sichuan University
2022-2023
Purpose A randomized, phase III trial demonstrated superiority of sunitinib over interferon alfa (IFN-α) in progression-free survival (primary end point) as first-line treatment for metastatic renal cell carcinoma (RCC). Final analyses and updated results are reported. Patients Methods Seven hundred fifty treatment-naïve patients with clear RCC were randomly assigned to 50 mg orally once daily on a 4 weeks on, 2 off dosing schedule or IFN-α 9 MU subcutaneously thrice weekly. Overall was...
To analyze final long-term survival and clinical outcomes from the randomized phase III study of sunitinib in gastrointestinal stromal tumor patients after imatinib failure; to assess correlative angiogenesis biomarkers with patient outcomes.Blinded or placebo was given daily on a 4-week-on/2-week-off treatment schedule. Placebo-assigned could cross over at disease progression/study unblinding. Overall (OS) analyzed using conventional statistical methods rank-preserving structural failure...
The development of diffuse large B-cell lymphoma (DLBCL), a prevalent subgroup non-Hodgkin (NHL), potentially involves various cytokines. We aimed to determine the correlation between deregulated serum levels cytokines and clinical features investigate their impact on prognosis patients with DLBCL.We conducted retrospective study 77 newly diagnosed DLBCL explore relationships different cytokines, adverse features, poor outcomes. Mann-Whitney U test was used compare cytokine profiles healthy...
Transurethral enucleation and resection of prostate (TUERP), as one the conventional surgical methods for patients with benign prostatic hyperplasia (BPH), usually resulted in pseudo urinary incontinence after surgery. The present study was thereby conducted to evaluate feasibility anterior lobe-preserving transurethral (ALP-TUERP) on reducing incidence rate surgery BPH. Patients diagnosed BPH underwent treatment were enrolled within inclusion criteria. Characteristics including age, volume...
Abstract Background Propofol combined with opioids can reduce the dosage of propofol and improve safety endoscopy. However, there are few studies on S-ketamine in children undergoing gastro-duodenoscopy. We aim to determine sedative effect different doses combination school-aged Methods This is a prospective, randomized trial. Totally, 120 who underwent gastro-duodenoscopy were randomly allocated into Group P, S 0.3 , 0.5 0.7 . During induction, received 0, mg.kg −1 S-ketamine, respectively,...
To investigate the clinical features, risk factors, and prognosis of intraocular recurrence in primary vitreoretinal lymphoma (PVRL). Retrospective case-control study. 97 eyes 51 patients diagnosed with PVRL between 2011/12 2021/1 were enrolled this 14 among them had experienced recurrence. Date on demographic ophthalmic characteristics, results diagnostic tests, treatments, non-recurrence collected compared. Multivariate logistic regression was used to identify independent factors. And...
Summary To reducing chemotherapy‐related toxicity, the chemo‐free regimens become a new trend of Ph + ALL treatment. Therefore, we conducted phase 2 trial dasatinib plus prednisone, as induction (Course I) and early consolidation (Courses II III) treating newly diagnosed ALL. The was registered at www.chictr.org.cn , ChiCTR2000038053. Forty‐one patients were enrolled from 15 hospitals. complete remission (CR) 95% (39/41), including two elderly deaths. By end Course III, 25.6% (10/39)...
Introduction Diabetes mellitus (DM) is a common endocrine disease resulting from interactions between genetic and environmental factors. Type II DM (T2DM) accounts for approximately 90% of all cases. Current medicines used in the treatment have some adverse or undesirable effects on patients, necessitating use alternative medications. Methods To overcome low bioavailability plant metabolites, entities were first screened through pharmacokinetic, network pharmacology, molecular docking...
To describe the breast milk intake of infants aged 0-5 months in China and its trends, to analyze effects feeding mode, gender regions on intake.
Abstract BACKGROUND: Resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) is a major challenge in non-small cell lung cancer (NSCLC) treatment. EGFR activating mutations, such as exon 19 deletions (Del19) and L858R substitution, have been reported 10-50% of patients with NSCLC. Although these respond well early generations TKIs, acquired resistance by mechanisms T790M mutation compromises their efficacy. Recently, the C797S combination Del19 or L858R,...
Acute ST-segment elevation myocardial infarction (STEMI) has a high morbidity and mortality rate. The congestive heart failure, hypertension, age, diabetes, previous stroke/transient ischemic attack (2 points) (CHADS2) CHADS2 score with 2 points assigned for age >75 years-vascular disease (CHA2DS2-VASc) scores are widely used risk stratification management of non-valvular atrial fibrillation stroke have prognostic value in cardiovascular disease. This study aims to investigate the predictive...
Numerous studies have confirmed the effects of low carbohydrate diet (LChD) on metabolism and chronic diseases. However, there were no bibliometric LChD. This study was conducted through a analysis to investigate current status, hotspots frontiers trends.We searched all research publications related LChD from 2002 2021 Web Scientific Core Collection (WoSCC). CiteSpace VOSviewer software used analyze countries/regions, institutions, journals, authors, references, keywords.A total 6938 papers...
As the development of various imaging techniques, incidental detection renal masses is increasing. Laparoscopic partial nephrectomy (LPN) current standard treatment for carcinoma. Though retroperitoneal laparoscopic (RLPN) become prior choice, edge lateroconal fascia blocks sight and make operation more challenging.Between October 2018 December 2020, clinical data 28 cases diagnosed with cell carcinoma (RCC) in our hospital was collected analyzed retrospectively. All patients underwent RLPN...
Abstract Respiratory coronaviruses (RCoVs) significantly threaten human health, necessitating the development of an ex vivo respiratory culture system for investigating RCoVs infection. Here, we successfully generated a porcine precision-cut lung slices (PCLSs) system, containing all resident cell types in their natural arrangement. Next, this was inoculated with coronavirus (PRCV), exhibiting clinical features akin to humans who were infected by SARS-CoV-2. The results demonstrated that...