A5080507158- Nuclear Physics and Applications
- Boron Compounds in Chemistry
- Radiation Detection and Scintillator Technologies
- Radiation Therapy and Dosimetry
- Nuclear Materials and Properties
- Boron and Carbon Nanomaterials Research
- Advanced Radiotherapy Techniques
- Advanced Semiconductor Detectors and Materials
- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Graphite, nuclear technology, radiation studies
- Machine Learning in Materials Science
- Nuclear reactor physics and engineering
- Radiation Effects and Dosimetry
- Magnetic confinement fusion research
- Atomic and Subatomic Physics Research
- Particle Detector Development and Performance
- Fusion materials and technologies
- Radiomics and Machine Learning in Medical Imaging
- Infrared Target Detection Methodologies
- Carcinogens and Genotoxicity Assessment
Istituto Nazionale di Fisica Nucleare, Sezione di Pavia
2017-2025
University of Pavia
2017-2018
Institute for Physics
2017-2018
Istituto Nazionale di Fisica Nucleare
2017-2018
Boron Neutron Capture Therapy (BNCT) is a form of radiotherapy based on the irradiation tumour with low energy neutron beam, after administration selective drug enriched in boron-10. The therapy exploits high cross section thermal capture boron, generating two low-range charged particles. availability accelerators able to generate high-intensity beams via proton nuclear interaction boosting construction new clinical centres. One these under development Italy, using 5 MeV, 30 mA...
Abstract Background Boron Neutron Capture Therapy (BNCT) is a binary radiotherapy based on the intravenous administration of borated drug to patient and subsequent irradiation with low‐energy neutron beam. The formulation accumulates in tumor cells, when neutrons interact boron, nuclear capture reaction occurs, releasing high‐linear energy transfer, short‐range particles that cause lethal damage cancer cells. Due its selectivity, BNCT has potential treat aggressive brain tumors such as...
(1) Background:The quality of neutron beams for Boron Neutron Capture Therapy (BNCT) is currently defined by its physical characteristics in air. Recommendations exist to define whether a designed beam useful clinical treatment. This work presents new way evaluate based on their performance and safety, employing radiobiological quantities. (2) Methods: The case study deep-seated tumors from 5 MeV proton coupled beryllium target. Physical Figures Merit were used design five beams; however,...
Abstract Boron Neutron Capture Therapy (BNCT) is a radiotherapy technique based on the enrichment of tumour cells with suitable 10-boron concentration and subsequent neutron irradiation. Low-energy irradiation produces localized deposition radiation dose caused by boron capture reactions. vehiculated into via proper borated formulations, able to accumulate in malignancy more than normal tissues. The releases two high-LET charged particles (i.e., an alpha particle lithium ion), losing their...
This work presents a preliminary evaluation of the use convolutional neural network nnU-NET to automatically contour volume Glioblastoma Multiforme in medical images patients. The goal is assist preparation Treatment Planning patients who undergo Boron Neutron Capture Therapy (BNCT). BNCT binary form radiotherapy based on selective loading suitable 10-boron concentration into tumour and subsequent low-energy neutron irradiation. selectivity therapeutic effect capacity boron drug target...
CdZnTe is nowadays a reference semiconductor for detection of X and γ-radiation. The electrical properties CdZnTe-based (CZT) detectors are strongly affected by the surface subsurface defects, which can cause an excessive leakage current (SLC). This issue degrades sensor performance becomes critical multi-stripes detectors, where stripes kept at different voltage potentials in order to shape electric field inside material.In this work, we propose passivation method based on deposition thin...
The National Institute of Nuclear Physics (INFN) is supporting the 3CaTS project with aim developing a new Single Photon Emission Computed Tomography (SPECT) system for real time <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">10</sup> B therapeutic dose monitoring in binary experimental hadron therapy called Boron Neutron Capture Therapy (BNCT). BNCT highly selective tumour treatment based on neutron capture reaction B(n,α)...
Boron Neutron Capture Therapy (BNCT) is a binary radiation therapy which able to selectively destroy malignant cells while sparing the normal tissue. A <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">10</sup> B containing drug target neoplastic administered patient then irradiated with thermal neutrons that induce B(n,alpha) xmlns:xlink="http://www.w3.org/1999/xlink">7</sup> Li capture reaction. Therefore BNCT effectiveness strongly dependent on...
Boron Neutron Capture Therapy (BNCT) effectiveness depends on the therapeutic dose delivered in tumour when targeted by a sufficient amount of 10B atoms and exposed to proper flux thermal neutrons. Presently these quantities are measured indirectly. The availability an vivo real time monitoring tool would be tremendous achievement fully exploit BNCT. To this end, Single-Photon Emission Computed Tomography (SPECT) can measure 478keV γ-ray emitted after 94% capture reactions. Presently, Italian...