A5029216972- Sports Performance and Training
- High Altitude and Hypoxia
- Exercise and Physiological Responses
- Muscle Physiology and Disorders
- Genetics and Physical Performance
- Adipose Tissue and Metabolism
- Muscle metabolism and nutrition
- Neurogenetic and Muscular Disorders Research
- Cardiovascular and Diving-Related Complications
- Cardiac electrophysiology and arrhythmias
- Neuroscience of respiration and sleep
- Cardiovascular and exercise physiology
- Cardiovascular Effects of Exercise
- Cardiomyopathy and Myosin Studies
- Amyotrophic Lateral Sclerosis Research
- Hip and Femur Fractures
- Heart Rate Variability and Autonomic Control
- Sports injuries and prevention
- Cardiac pacing and defibrillation studies
- Dietary Effects on Health
- Cardiac Fibrosis and Remodeling
- Spine and Intervertebral Disc Pathology
- Bone fractures and treatments
- Tryptophan and brain disorders
- Hemoglobinopathies and Related Disorders
AO Foundation
2013-2025
Institute for Biomedicine
2022-2023
Eurac Research
2020-2023
Karolinska Institutet
2015-2022
Institute of Mountain Emergency Medicine
2020-2022
Lithuanian Sports University
2016-2019
ETH Zurich
2009
Physical exercise has emerged as an alternative treatment for patients with depressive disorder. Recent animal studies show that protects from depression by increased skeletal muscle kynurenine aminotransferase (KAT) expression which shifts the metabolism away neurotoxic (KYN) to production of kynurenic acid (KYNA). In present study, we investigated effect on in humans. KAT gene and protein was muscles endurance-trained subjects compared untrained subjects. Endurance caused increase plasma...
The protein α-actinin-3 expressed in fast-twitch skeletal muscle fiber is absent 1.5 billion people worldwide due to homozygosity for a nonsense polymorphism ACTN3 (R577X). prevalence of the 577X allele increased as modern humans moved colder climates, suggesting link between deficiency and improved cold tolerance. Here, we show that lacking (XX) are superior maintaining core body temperature during cold-water immersion changes thermogenesis. Muscles XX individuals displayed shift toward...
Acclimatization to hypoxia leads a reduction in plasma volume (PV) that restores arterial O2 content. Findings from studies investigating the mechanisms underlying this PV contraction have been controversial, possibly as experimental conditions were inadequately controlled. We examined evoked by 4 days of exposure hypobaric (HH) 11 healthy lowlanders, while strictly controlling water intake, diet, temperature and physical activity. Exposure HH-induced an ∼10% was accompanied total...
There is a risk of hip injury in dives to the side by soccer goalkeepers. In this study, we assessed loading goalkeepers when performing such dives. The experiments were conducted laboratory setting using an in-ground force plate as well on grass surface athletes equipped with sensors. forces acting measured and high-speed video analysis was performed, allowing investigation dive characteristics techniques. peak values recorded ranged from 3 8 kN, which corresponded 4.2-8.6 times body...
Using a normoxic crossover study design, we examined the impact of hypobaric hypoxia (4 days; altitude equivalent, 3,500 m) and hemoconcentration on blood viscosity, shear stress, endothelial function. Blood viscosity increased during hypoxic exposure was accompanied by elevated resting exercising arterial stress. Flow-mediated dilation stimulated reactive hyperemia handgrip exercise preserved throughout exposure. Plasma volume expansion reversed hypoxia-associated selectively flow-mediated dilation.
Key points How defects in muscle contractile function contribute to weakness amyotrophic lateral sclerosis (ALS) were systematically investigated. Weakness whole muscles from late stage SOD1 G93A mice was explained by atrophy as seen reduced mass and maximal force. On the other hand, surviving single fibres have preserved intracellular Ca 2+ handling, normal force‐generating capacity increased fatigue resistance. These intriguing findings provide a substrate for therapeutic interventions...
Altitude exposure may suppress appetite and hence provide a viable weight-loss strategy. While changes in food intake availability as well physical activity contribute to altered at altitude, herein we aimed investigate the isolated effects of hypobaric hypoxia on regulation sensation. Twelve healthy women (age: 24.0 ± 4.2 years, body mass: 60.6 7.0 kg) completed two 4-day sojourns chamber, one normoxia [PB = 761 mmHg, 262 m (NX)] 493 mmHg (HH)] equivalent 3,500-m altitude. Energy was...
We investigated whether low arterial oxygen tension ([Formula: see text]) or hypoxia-induced plasma volume (PV) contraction, which reduces central blood (BV) and atrial distension, explain reduction in circulating natriuretic peptide (ANP) after prolonged hypoxic exposure. Ten healthy males were exposed for 4 days to hypobaric hypoxia corresponding an altitude of 3,500 m. PV changes determined by carbon monoxide rebreathing. Venous concentrations midregional proANP (MR-proANP) measured...
Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) are commonly used to model arrhythmogenic cardiomyopathy (ACM), a heritable cardiac disease characterized by severe ventricular arrhythmias, fibrofatty myocardial replacement and progressive dysfunction. Although ACM is inherited as an autosomal dominant disease, incomplete penetrance variable expressivity extremely common, resulting in different clinical manifestations. Here, we propose hiPSC-CMs powerful vitro study...
ABSTRACT The fast skeletal muscle protein α-actinin-3 is absent in 1.5 billion people worldwide due to homozygosity for a nonsense polymorphism the ACTN3 gene (R577X) 1 . prevalence of 577X allele increased as modern humans moved colder climates, suggesting link between deficiency and improved cold tolerance 1,2 Here, we show that lacking (XX) are superior maintaining core body temperature during cold-water immersion changes thermogenesis. Muscles XX individuals displayed shift towards more...
Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – EU funding. Main source(s): European Regional Development Fund and Interreg V-A Italy-Austria 2014-2020 Department Innovation, Research University the Autonomous Province Bolzano-South Tyrol (Italy). Background Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) were previously used to model several inherited heart diseases (1). Among these, arrhythmogenic cardiomyopathy (ACM) is characterized by...