A5085874543- Osteoarthritis Treatment and Mechanisms
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Spine and Intervertebral Disc Pathology
- Tissue Engineering and Regenerative Medicine
- Musculoskeletal pain and rehabilitation
- Additive Manufacturing and 3D Printing Technologies
- Proteoglycans and glycosaminoglycans research
- Medical Imaging and Analysis
- Collagen: Extraction and Characterization
- Knee injuries and reconstruction techniques
- Reconstructive Surgery and Microvascular Techniques
- Photopolymerization techniques and applications
AO Foundation
2023-2025
ETH Zurich
2023-2025
Institute for Biomedical Engineering
2023-2024
Imperial College London
2023
Cartilage Decellularized ExtraCellular Matrix (dECM) materials have shown promising cartilage regeneration capacity due to their chondrogenic bioactivity. However, the limited retention of ECM components and reduced integrity functional molecules during traditional decellularization processes impair biomimicry these materials. The current study aims fabricate biomimetic containing decellularized particles that an intact molecular structure native composition as biomaterial inks hydrogels for...
The role of poroelasticity on the functional performance articular cartilage has been established in scientific literature since 1960s. Despite extensive knowledge this topic there remain few attempts to design for and our no demonstration an engineered poroelastic material that approaches physiological performance. In paper, we report development begins approach poroelasticity. We quantify using fluid load fraction, apply mixture theory model system, determine cytocompatibility primary...
Collagen/hyaluronan hydrogels with physical properties well suited for biomedical applications are challenging to synthesize due the formation of polyionic complexes (PICs). A systematic physicochemical study was thus performed determine novel conditions inhibit collagen/hyaluronan PICs and obtain composite high properties. Using a range pH from 1 5.5 addition NaCl, type I collagen tyramine-substituted hyaluronic acid (THA) solutions were mixed analyzed by cryo-scanning electron microscopy...
INTRODUCTION Intervertebral disc (IVD) degeneration is not completely understood because of the lack relevant models. In vivo models are inappropriate animals quadrupeds. IVD composed Nucleus Pulposus (NP) and Annulus Fibrosus (AF), an elastic tissue that surrounds NP. AF consists concentric lamellae made collagen I glycosaminoglycans with fibroblast-like cells located between layers. this study, we aimed to develop a novel 3D in vitro model study its degeneration. For purpose, reproduced...