A5071141773- Mast cells and histamine
- Genomics, phytochemicals, and oxidative stress
- Asthma and respiratory diseases
- Polyamine Metabolism and Applications
- Gut microbiota and health
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Ion channel regulation and function
- Medical and Biological Ozone Research
- PI3K/AKT/mTOR signaling in cancer
- Barrier Structure and Function Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Phagocytosis and Immune Regulation
- Genetics, Aging, and Longevity in Model Organisms
- Cardiac electrophysiology and arrhythmias
- Bladder and Urothelial Cancer Treatments
- Parasites and Host Interactions
- Urticaria and Related Conditions
- Biochemical effects in animals
- S100 Proteins and Annexins
- Telomeres, Telomerase, and Senescence
- Redox biology and oxidative stress
- Vitamin C and Antioxidants Research
- Receptor Mechanisms and Signaling
- Immune Cell Function and Interaction
- Hernia repair and management
Lomonosov Moscow State University
2014-2024
Moscow State University
2014-2024
Pirogov Russian National Research Medical University
2022-2023
Ministry of Health of the Russian Federation
2022-2023
Hospital at Smolensk Station
2016
Institute of Experimental Cardiology
2014
There is accumulating evidence that mitochondria and mitochondrial STAT3 are involved in the activation of mast cells. The mitochondria-targeted curcuminoids Mitocur-1 Mitocur-3 have been suggested to reduce antigen-dependent cell by inhibiting STAT3. aim current work was investigate mechanisms action these mitocurcuminoids on cells functions. pretreatment rat basophilic leukemia RBL-2H3 with decreased degranulation but did not affect spontaneous degranulation. Both compounds caused...
Mitochondria-targeted antioxidants have become promising candidates for the therapy of various pathologies. The mitochondria-targeted antioxidant SkQ1, which is a derivative plastoquinone, has been successfully used in preclinical studies treatment cardiovascular and renal diseases, demonstrated anti-inflammatory activity number inflammatory disease models. present work aimed to investigate therapeutic potential SkQ1 C12TPP, analog lacking quinone moiety, prevention sodium dextran sulfate...
Abstract Inflammatory bowel disease (IBD) is widespread in industrial countries with every 20th citizen being affected. Dysregulation of the epithelial barrier function considered to play a key role IBD. Permeability intestinal epithelium depends mostly on its self-renewal potential and condition intercellular junctions. Mitochondria are involved regulating various intracellular processes addition their energy function. Recent data implicate mitochondria regulation Mitochondrial dysfunction...
To assess an incidence rate of surgical site infections (SSI) after open appendectomy and effectiveness combined preventive measures (CPM).This study was performed at three departments Smolensk hospitals. A total 150 consecutive patients (50 each department) hospitalized since January 2012 were included into the retrospective observation (period I). In order to perform prospective evaluation CPM, a 66 (randomized 1:1) December II) followed up departments. Antibiotic prophylaxis (AP) with IV...
The peripheral blood monocytes of atherosclerotic patients are pre-activated and have some the features tissue macrophages. Their adhesion to endothelium is 1.5 times higher than that from healthy subjects, they express a number receptors antigens typical Additionally, earlier we showed biosynthesis gangliosides, whose main function formation membrane rafts, significantly activated in patients, as well during vitro differentiation normal into In this study, investigated expression rafts on...
Inflammatory bowel disease (IBD) is widespread in industrial countries with every 20th citizen being affected. Dysregulation of the epithelial barrier function considered to play a key role IBD. Permeability intestinal epithelium depends mostly on its self-renewal potential and condition intercellular junctions. Mitochondria are involved regulating various intracellular processes addition their energy function. Recent data implicate mitochondria regulation Mitochondrial dysfunction possibly...
Urban dust particles are a major pathogenic factor in respiratory diseases such as asthma and chronic obstructive pulmonary disease, also increase the risk of cardiovascular disease lung cancer. Nanoparticles (NPs) various origins an important component urban dust, but their effects on human body barely studied. In present work, effect NPs innate immune cells, neutrophils macrophages was investigated vitro. nanoparticles were isolated from samples using coiled tube field-flow fractionation...
Background. The field of gerontology is actively seeking senolytics and senomorphs that can influence the quantity activity senescent cells in body. Previous studies have demonstrated geroprotective properties mitochondrial- directed compounds based on plastoquinone berberine various vitro vivo models. Thus, it plausible SkQBerb, a mitochondrialtargeted compound combining plastoquinone, may exhibit higher potential compared to previously studied compounds.Objective. aim this study...