A5081912348- Gut microbiota and health
- Muscle Physiology and Disorders
- Mitochondrial Function and Pathology
- Barrier Structure and Function Studies
- Autophagy in Disease and Therapy
- Vitamin C and Antioxidants Research
- Drug Transport and Resistance Mechanisms
- Trace Elements in Health
- Genomics, phytochemicals, and oxidative stress
Lomonosov Moscow State University
2022-2023
Many muscular pathologies are associated with oxidative stress and elevated levels of the tumor necrosis factor (TNF) that cause muscle protein catabolism impair myogenesis. Myogenesis defects caused by TNF mediated in part reactive oxygen species (ROS), including those produced mitochondria (mitoROS), but mechanism their pathological action is not fully understood. We hypothesized mitoROS act triggering enhancing mitophagy, an important tool for remodelling mitochondrial reticulum during...
Mitochondria-targeted antioxidants have become promising candidates for the therapy of various pathologies. The mitochondria-targeted antioxidant SkQ1, which is a derivative plastoquinone, has been successfully used in preclinical studies treatment cardiovascular and renal diseases, demonstrated anti-inflammatory activity number inflammatory disease models. present work aimed to investigate therapeutic potential SkQ1 C12TPP, analog lacking quinone moiety, prevention sodium dextran sulfate...
Abstract Inflammatory bowel disease (IBD) is widespread in industrial countries with every 20th citizen being affected. Dysregulation of the epithelial barrier function considered to play a key role IBD. Permeability intestinal epithelium depends mostly on its self-renewal potential and condition intercellular junctions. Mitochondria are involved regulating various intracellular processes addition their energy function. Recent data implicate mitochondria regulation Mitochondrial dysfunction...
Inflammatory bowel disease (IBD) is widespread in industrial countries with every 20th citizen being affected. Dysregulation of the epithelial barrier function considered to play a key role IBD. Permeability intestinal epithelium depends mostly on its self-renewal potential and condition intercellular junctions. Mitochondria are involved regulating various intracellular processes addition their energy function. Recent data implicate mitochondria regulation Mitochondrial dysfunction possibly...