A5019040835- Advanced Sensor and Energy Harvesting Materials
- Neuroscience and Neural Engineering
- EEG and Brain-Computer Interfaces
- Vagus Nerve Stimulation Research
- Cholesterol and Lipid Metabolism
- Heart Rate Variability and Autonomic Control
- Stress Responses and Cortisol
- Muscle activation and electromyography studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Memory and Neural Mechanisms
- Peroxisome Proliferator-Activated Receptors
- Photoreceptor and optogenetics research
- Force Microscopy Techniques and Applications
- Wireless Body Area Networks
- Biosensors and Analytical Detection
- Neuroendocrine regulation and behavior
- Analytical Chemistry and Sensors
- Tactile and Sensory Interactions
- Urinary Bladder and Prostate Research
- Wireless Power Transfer Systems
- Lipid metabolism and biosynthesis
- Barrier Structure and Function Studies
- Single-cell and spatial transcriptomics
- Advanced Chemical Sensor Technologies
- Neuroscience and Neuropharmacology Research
Stanford University
2020-2024
Neurosciences Institute
2023-2024
University of California, San Diego
2017-2023
University of California System
2018
Despite tremendous recent efforts, noninvasive sweat monitoring is still far from delivering its early analytical promise. Here, we describe a flexible epidermal microfluidic detection platform fabricated through hybridization of lithographic and screen-printed technologies, for efficient fast sampling continuous, real-time electrochemical glucose lactate levels. This soft, skin-mounted device judiciously merges lab-on-a-chip integrated with miniaturized electronic board wireless data...
Abstract Several genetic risk factors for Alzheimer’s disease implicate genes involved in lipid metabolism and many of these are highly expressed glial cells 1 . However, the relationship between glia pathology remains poorly understood. Through single-nucleus RNA sequencing brain tissue disease, we have identified a microglial state defined by expression droplet-associated enzyme ACSL1 with ACSL1-positive microglia being most abundant patients having APOE4/4 genotype. In human induced...
Abstract A flexible skin‐mounted microfluidic potentiometric device for simultaneous electrochemical monitoring of sodium and potassium in sweat is presented. The wearable allows efficient natural pumping to the detection chamber, containing solid‐contact ion‐selective Na + K electrodes, during exercise activity. fabricated microchip electrolyte‐sensing displays good analytical performance addresses mixing carry‐over issues early epidermal sensors. Such soft skin‐worn platform integrates...
Pavlovian fear conditioning, which offers the advantage of simplicity in both control conditional and unconditional stimuli (CS, US) presentation analysis specific responses (CR, UR) a controlled laboratory setting, has been standard model basic translational research. Despite 100 years experiments, utility conditioning not trans-situationally validated real-life contexts. We thus investigated whether readily occurs guides animal's future behavior an ecologically-relevant environment. To do...
Abstract Several genetic risk factors for Alzheimer’s Disease (AD) implicate genes involved in lipid metabolism and many of these are highly expressed glial cells. However, the relationship between glia AD pathology remains poorly understood. Through single-nucleus RNA-sequencing brain tissue, we have identified a microglial state defined by expression droplet (LD) associated enzyme ACSL1 with ACSL1-positive microglia most abundant patients APOE4/4 genotype. In human iPSC-derived (iMG)...
Abstract Here, an unobtrusive, adhesive‐integrated electrode array for continuous monitoring of stomach electric activity is introduced. This patient‐friendly, disposable peel‐and‐stick adhesive device represents important advancement over existing arrays that require placement each individually and are thus also labor intensive in general more rigid cumbersome. In comparison to other silver–silver chloride electrodes, this skin conformal does not gel can withstand low impedance the duration...
Fingerprint-inspired relief structures increase differences in friction when sliding across hydrophobic and hydrophilic surfaces.
Abstract Flexible and stretchable electronics are a logical choice for the recording of biopotentials, due to their improved patient comfort customizability. There is, however, significant variance in signal quality received from these electrodes based on material, size, target frequency. Here we develop methodology Electrochemical Impedance Spectroscopy (EIS) circuit modeling optimizing specific application. We use EIS measure frequency dependent impedance characteristics gold (Au)...
Abstract This study introduces a flexible, adhesive-integrated electrode array that was developed to enable non-invasive monitoring of cervical nerve activity. The device uses silver-silver chloride as the material choice and combines it with an consisting customized biopotential data acquisition unit integrated graphical user interface (GUI) for visualization real-time monitoring. Preliminary testing demonstrated this design can achieve high signal noise ratio during neural recordings. To...
Abstract Neural modulation techniques with electricity, light and other forms of energy have enabled the deconstruction neural circuitry. One major challenge existing is invasive brain implants permanent skull attachment an optical fiber for modulating activity in deep brain. Here we report implant-free tether-free neuromodulation technique deep-brain regions through intact scalp brain-penetrant second near-infrared (NIR-II) illumination. Macromolecular infrared nanotransducers stimulation...
Abstract Pavlovian fear conditioning, which offers the advantage of simplicity in both control conditioned and unconditioned stimuli (CS, US) presentation analysis specific responses (CR, UR) a controlled laboratory setting, has been standard model basic translational research. Despite 100 years experiments, utility conditioning not trans-situationally validated real-life contexts. We thus investigated whether readily occurs guides animal’s future behavior an ecologically-relevant...
Abstract We developed a high‐resolution and noninvasive multichannel urodynamic system combined with novel signal‐processing algorithm tailored to extract electromyographic (EMG) activity from the urinary bladder. utilized flexible biopotential recording collect an array of EMG signals bladder human subjects. This study also presents use existing artifact rejection methodology autonomously signal environment prone motion artifacts.
Abstract This study introduces a flexible, adhesive-integrated electrode array that was developed to enable non-invasive monitoring of cervical nerve activity. The device uses silver-silver chloride as the material choice and combines it with novel consisting customized biopotential data acquisition unit integrated graphical user interface (GUI) for visualization real-time monitoring. Preliminary testing demonstrated this design can achieve high signal noise ratio during neural recordings....
Abstract This study introduces a flexible, adhesive-integrated electrode array that was developed to enable non-invasive monitoring of cervical nerve activity. The device uses silver-silver chloride as the material choice and combines it with novel consisting customized biopotential data acquisition unit integrated graphical user interface (GUI) for visualization real-time monitoring. Preliminary testing demonstrated this design can achieve high signal noise ratio during neural recordings....