A5048123004- Protein Structure and Dynamics
- CO2 Reduction Techniques and Catalysts
- Neuroscience and Neural Engineering
- Ionic liquids properties and applications
- Electrocatalysts for Energy Conversion
- Photoreceptor and optogenetics research
- Advanced Fluorescence Microscopy Techniques
- RNA Research and Splicing
- Advanced Photocatalysis Techniques
- Health, Environment, Cognitive Aging
- Spectroscopy and Quantum Chemical Studies
- Endoplasmic Reticulum Stress and Disease
- Molecular Communication and Nanonetworks
- Microbial Inactivation Methods
- Connexins and lens biology
- Innovative Microfluidic and Catalytic Techniques Innovation
- Diet and metabolism studies
- Carbon dioxide utilization in catalysis
- Metabolism and Genetic Disorders
- Coenzyme Q10 studies and effects
- Advanced battery technologies research
- Lipid metabolism and biosynthesis
- Vagus Nerve Stimulation Research
- Heat shock proteins research
Harvard University
2022-2024
Stanford University
2019-2022
Fudan University
2017-2021
Neurosciences Institute
2019-2020
Collaborative Innovation Center of Chemistry for Energy Materials
2017-2018
Optogenetics, which uses visible light to control the cells genetically modified with light-gated ion channels, is a powerful tool for precise deconstruction of neural circuitry neuron-subtype specificity. However, due limited tissue penetration light, invasive craniotomy and intracranial implantation tethered optical fibers are usually required in vivo optogenetic modulation. Here we report mechanoluminescent nanoparticles that can act as local sources brain when triggered by...
Solar-driven electrochemical carbon dioxide (CO2) reduction is capable of producing value-added chemicals and represents a potential route to alleviate footprint in the global environment. However, ever-changing sunlight illumination presents substantial impediment maintaining high electrocatalytic efficiency stability for practical applications. Inspired by green plant photosynthesis with separate light reaction (dark) fixation steps, herein, we developed redox-medium-assisted system that...
Abstract Neural modulation techniques with electricity, light and other forms of energy have enabled the deconstruction neural circuitry. One major challenge existing is invasive brain implants permanent skull attachment an optical fiber for modulating activity in deep brain. Here we report implant-free tether-free neuromodulation technique deep-brain regions through intact scalp brain-penetrant second near-infrared (NIR-II) illumination. Macromolecular infrared nanotransducers stimulation...
Electrolytes are essential parts of the environment for all life forms, where proteins, water, and solutes interplay to support vital activities. However, a fundamental understanding effect ionic on proteins remains elusive more than century. Here we show how some can serve as potent denaturants despite absence direct protein-ion interactions. We demonstrate dramatic differences between denaturation potency different with lithium bromide (LiBr) being strongest denaturant sodium (NaBr) least...
Abstract In this work we investigate how spatial proximity of enzymes belonging to the same pathway (metabolon) affects metabolic flux. Using off-lattice Langevin Dynamics (LD) simulations in tandem with a stochastic reaction-diffusion protocol and semi-analytical model, systematically explored strength protein-protein interactions, catalytic efficiency protein-ligand interactions affect flux through metabolon. Formation metabolon leads greater speed up for longer pathways especially...