A5013727305- Organometallic Complex Synthesis and Catalysis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Metal complexes synthesis and properties
- Ferrocene Chemistry and Applications
- Electrochemical Analysis and Applications
- Synthesis and Biological Evaluation
- Asymmetric Hydrogenation and Catalysis
- Molecular Sensors and Ion Detection
- Carbon dioxide utilization in catalysis
- Synthesis and characterization of novel inorganic/organometallic compounds
- Electrochemical sensors and biosensors
- Fluorine in Organic Chemistry
- Analytical Chemistry and Sensors
- Photochemistry and Electron Transfer Studies
- Inorganic Chemistry and Materials
- Organoboron and organosilicon chemistry
- Synthetic Organic Chemistry Methods
- Synthesis and biological activity
- Catalytic Alkyne Reactions
- Crystallography and molecular interactions
- CO2 Reduction Techniques and Catalysts
- Radiopharmaceutical Chemistry and Applications
- Catalytic Cross-Coupling Reactions
- Machine Learning in Materials Science
Universidad de Santiago de Chile
2015-2025
Instituto de Química y Fisicoquímica Biológicas
2020
State Key Laboratory of Organometallic Chemistry
2017-2018
Faculty (United Kingdom)
2017-2018
Tenaris (United States)
2018
Valparaiso University
1997-2009
Pontificia Universidad Católica de Valparaíso
1998-2008
Universidad de Zaragoza
2003
Simon Fraser University
1998
University of Chile
1998
Four new Pd(II) complexes containing sulfonate-functionalized N-heterocyclic carbene ligands have been synthesized. All are palladium bis-NHCs, in which the adopt a monodentate, bis-chelating, and pincer coordination form, so that good comparison between their catalytic activities can be performed. The used Suzuki−Miyaura cross-coupling reaction aryl halides phenylboronic acid water iPrOH/water. bis-NHC-palladium complex 1, two NHC relative cis configuration, affords best outcomes, with high...
The formation of oligomeric soluble aggregates is related to the toxicity amyloid peptides and proteins. In this manuscript, we report use a ruthenium polypyridyl complex ([Ru(bpy)2(dpqp)]2+) track oligomers at different times using photoluminescence anisotropy. This technique sensitive rotational correlation time molecule under study, which consequently size molecule. [Ru(bpy)2(dpqp)]2+ presents anisotropy values zero when free in solution (due its rapid rotation long lifetime) but larger...
Zileuton is the only FDA-approved 5-lipoxygenase (5-LOX) inhibitor for asthma treatment, but it produces hepatotoxicity associated with benzothiophene fragment. Using concept of organometallic derivatization pioneered by Jaouen and Brocard, we synthesized five new derivatives, maintaining urea fragment incorporating ferrocenyl ruthenocenyl moiety (3a-e). Their biological activity was evaluated against 5-LOX, 15-LOX, COX-1, COX-2 enzymes. The N-hydroxyurea complexes coined Ferroleuton (3a)...
Substituted amino-piperazine derivatives were synthesized and used as precursors for the preparation of a series new organometallic Re(i) imine complexes with general formula [(η5-C5H4CH[double bond, length m-dash]N-(CH2)5-Pz-R)Re(CO)3] (Pz-R: -alkyl or aryl piperazine). The piperazine-based ligands designed to be potential inhibitors GSK-3β kinase. All fully characterized evaluated against HT-29 PT-45 cancer cell lines, in which plays crucial role. In this context, we carried out biological...
The UV irradiation of [Re(η5-C5Me5)(CO)3] in the presence C6F6 effected intermolecular C–F and intramolecular C–H activation generating [Re(η6-C5Me4CH2)(CO)2(C6F5)] 1a two isomeric forms. In major isomer CH2 group lies trans to C6F5 both solution crystal. minor cis group. A similar reaction with C6F5CF3 generates [Re(η6-C5Me4CH2)(CO)2(C6F4CF3)] 1b four form CF3 is 4 position C6F4CF3 other three isomers are formed by rotation η6-C5Me4CH2 ligand as above, placing at 3 position, a combination...
This article reports the synthesis and characterisation of two lower rim calix[4]arene derivatives with thiourea as spacer pyrene or methylene-pyrene fluorophore.
UV Irradiation of [Re(η5-C5R5)(CO)3] (R = Me or H) in the presence C6F5H 1,2,4,5-C6F4H2 effected intramolecular C–H activation, generating hydrido complexes trans-[Re(η5-C5R5)(CO)2(Ar)FH] [(Ar)F C6F5 2,3,5,6-C6F4H] as principal photochemical products. The identities were confirmed by independent thermal syntheses. photoreaction [Re(η5-C5Me5)(CO)3] with also generated fulvene complex [Re(η6-C5Me4CH2)(CO)2(C6F5)] 2a and two bis(aryl) derivatives: cis-[Re(η5-C5Me5)(CO)2(C6F5)2] 3a...
Cyrhetrenyl aldehyde derivatives [(η5-C5H4CHO)Re(CO)2PR3] with R = methyl (Me, 2a), phenyl (Ph, 2b), and cyclohexyl (Cy, 2c) were synthesized by a photochemical reaction from the starting material [(η5-C5H4CHO)Re(CO)3] (1) corresponding phosphines. The complexes fully characterized FT-IR, 1H, 13C 31P NMR spectroscopy, elemental analysis mass spectrometry. molecular structures of 2a-c have also been determined. Electronic structure calculations TD-DFT electrochemical studies are in sound...
The synthesis, characterization, X-ray crystal structure, and study of the reactivity novel cyretrenyl ligand [{(η5-C5H4-2-C5H4N)}Re(CO)3 (1) with Pd(OAc)2 or [MCl2(DMSO)2] (M = Pd, Pt) are reported. These studies have allowed us to obtain bis-μ-ligand cyclopalladated complexes [Pd{[κ2-C,N-(η5-C5H3)-2(C5H4N)]Re(CO)3)}(μ-X)]2 (X OAc (2a), Cl (4a)) monomeric pallada- platinacycles general formula [M{[κ2-C,N-(η5-C5H3)-2(C5H4N)]Re(CO)3}(X)(L)] L PPh3, X (3a), (5a); M DMSO, (6a); Pt, Cl, PPh3...
The fulvene complexes (η6-C5Me4CH2)Re(CO)2R (1, R = C6F5; 2, I) react at the exocyclic methylene carbon with allylmagnesium chloride or 2-thienyllithium to yield anionic species [(η5-C5Me4CH2L)Re(CO)2R]- (L −CH2CHCH2, −2-C4H3S). Further reaction CH3I room temperature affords methyl (η5-C5Me4CH2L)Re(CO)2(R)(Me) (3, 4, I). Protonation of HCl low gives hydride trans-(η5-C5Me4CH2L)Re(CO)2(R)(H) (5, 6, Thermolysis hexane solutions under CO atmosphere, produces tricarbonyl (η5-C5Me4CH2L)Re(CO)3...
Abstract The photoinduced isomerization ( E to Z ) processes of a new series organometallic chalcones derived from cyrhetrene, ferrocene and cymantrene functionalized with benzo or 4′‐benzo‐15‐crown‐5 moiety were studied in acetonitrile. influence near‐UV steady‐state irradiation on the properties was followed by means UV/Vis absorption 1 H NMR spectroscopy. Time‐resolved ultrafast transient nanosecond flash photolysis spectroscopic studies revealed that ‐cyrhetrenyl , b led formation an...
In the search for new human 5-lipoxygenase (5-hLOX) inhibitors that could be used treatment of a variety inflammation-related diseases, three ferrocenyl complexes derived from 2,4-thiazole and thiazolo[5,4-d]thiazole ((η5-C5H4-2,4-thiazol-3,4-dihydroxyphenyl)Fe(η5-C5H5) (3), (η5-C5H4-2,4-thiazol-phenyl)Fe(η5-C5H5) (4), (η5-C5H4-thiazolo[5,4-d]thiazole-3,4-dihydroxybenzene)Fe(η5-C5H5) (5)) were synthesized evaluated. A cooperative effect among ferrocenyl, thiazole, catechol fragments was...
The fulvene complex (η6-C5Me4CH2)Re(C6F5)(CO)2 reacts at the exocyclic methylene carbon with potassium diphenylphosphide to yield anionic species [(η5-C5Me4CH2PPh2)Re(C6F5)(CO)2]− (1). Protonation of 1 HCl 0 °C produces hydride trans-(η5-C5Me4CH2PPh2)Re(C6F5)(H)(CO)2 (2). Thermolysis a hexanes solution 2, under nitrogen atmosphere, chelated (η5:η1-C5Me4CH2PPh2)Re(CO)2 (3) in good yield. thermolysis CO atmosphere affords mixture complexes and (η5-C5Me4CH2PPh2)Re(CO)3 (4a). reaction 3 two...