A5086659002- Metal-Catalyzed Oxygenation Mechanisms
- Microbial metabolism and enzyme function
- Microbial bioremediation and biosurfactants
- Quantum Dots Synthesis And Properties
- Reconstructive Surgery and Microvascular Techniques
- Molecular Junctions and Nanostructures
- Surgical Sutures and Adhesives
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Clinical Laboratory Practices and Quality Control
- Real-time simulation and control systems
- Radioactive element chemistry and processing
- Vascular Procedures and Complications
- Adipose Tissue and Metabolism
- Heme Oxygenase-1 and Carbon Monoxide
- Water Treatment and Disinfection
- Dental materials and restorations
- Antimicrobial Resistance in Staphylococcus
- Diverticular Disease and Complications
- Photosynthetic Processes and Mechanisms
- solar cell performance optimization
- Renal function and acid-base balance
- Cardiac Ischemia and Reperfusion
- Advanced Data Processing Techniques
- Renal cell carcinoma treatment
- Antibiotic Resistance in Bacteria
Duke University
2004-2025
University of Toledo
2024
University of Minnesota
1971-2021
Cardiff University
2011-2012
Sandia National Laboratories
2008-2009
Center for Integrated Nanotechnologies
2009
Washington University in St. Louis
2009
Simon Fraser University
2008
Bulgarian Academy of Sciences
2008
Soluble methane monooxygenase (sMMO) is a multicomponent metalloenzyme that catalyzes the conversion of to methanol at ambient temperature using nonheme, oxygen-bridged dinuclear iron cluster in active site. Structural changes hydroxylase component (sMMOH) containing diiron caused by complex formation with regulatory (MMOB) and reduction are important for regulation O
Background: The increased hospital morbidity and mortality associated with hyponatremia is well recognized in the critically ill pediatric population. Neonates infants exposed to vasopressin following cardiopulmonary bypass (CPB) may be at risk for hyponatremia. We aimed determine effect potential factors leading sodium variability immediate postoperative period neonates up 90 days of age surgery congenital heart disease. Methods: This was a retrospective review 75 consecutive patients...
The metalloenzyme soluble methane monooxygenase (sMMO) consists of hydroxylase (sMMOH), regulatory (MMOB), and reductase components. When sMMOH forms a complex with MMOB, the rate constants are greatly increased for sequential access O
Infrared spectroscopic ellipsometry was used for determination of molecular orientation and lateral homogeneity studies organic monolayers on GaAs Au, the layer being either octanedithiol or hexadecanethiol (HDT). The laterally resolved measurements were performed with infrared mapping ellipsometer at synchrotron storage ring BESSY II. within determined by optical model simulations measured ellipsometric spectra. Different tilt angles obtained HDT GaAs: 19° >30°, respectively. angle...
We have investigated the reaction pathways involved in electron-beam-induced damage of −CH3, −OH, and −COOH terminated alkanethiolate self-assembled monolayers (SAMs) adsorbed on GaAs (001) using time-of-flight secondary ion mass spectrometry. Upon electron beam exposure, dehydrogenate, leading to formation C═C bonds, cross-links, polycyclic aromatic hydrocarbons (PAHs). also observe C−S bond scission. The data suggest that is not uniform along alkanethiol backbone. we loss CO2 H2O from −OH...
Soluble methane monooxygenase (sMMO) is a multicomponent metalloenzyme capable of catalyzing the fissure C-H bond and insertion one atom oxygen from O
Heart surgery is associated with impairment of the myocardial beta-adrenoceptor (betaAR) system. Effective therapies for post-operative ventricular dysfunction are limited. Prolonged inotrope exposure further betaAR down-regulation. Left (LV) and were assessed following cardiopulmonary bypass (CPB) cardioplegic arrest in a pig model. Transfer human beta2-adrenoceptor transgene (Adeno-beta2AR) during was then tested as potential therapy.Five groups six neonatal piglets studied. One group did...
This is a general guideline aimed at providing laboratories with practical framework for validation and change control which required under the regulatory framework. should be applied when introducing new or changing to relocation of: established, critical process equipment, facilities systems in transfusion laboratory. The following areas are covered detail: Change – formal system managing change. Validation documented evidence that process, systems, operating within established parameters,...
Abstract Outbursts from young Class 0 protostars are now being detected using 3–5 μ m light curves assembled Spitzer and WISE/NEOWISE photometry. For comparison, we present a 4–8 curve of the erupting, more evolved protostar V1647 Ori (HOPS 388), photometry obtained with ISOCAM camera on ISO, IRAC Spitzer, WISE NEOWISE. Covering 26 yr, this spans longest available time interval infrared space-based telescopes capable separating individual stellar objects in nearby molecular clouds. This does...
Full activity of soluble methane monooxygenase (sMMO) depends upon the formation a 1:1 complex regulatory protein MMOB with each alpha subunit (αβγ)2 hydroxylase, sMMOH. Previous studies have shown that mutations in core region and N- C-termini cause dramatic changes rate constants for steps sMMOH reaction cycle. Here, X-ray crystal structures are reported two double variants within MMOB, DBL1 (N107G/S110A), DBL2 (S109A/T111A), as well N-terminal region, H33A H5A. causes 150-fold decrease...