About
Contact & Profiles
A5091418844
Research Areas
- Memory and Neural Mechanisms
- Cholinesterase and Neurodegenerative Diseases
- Alzheimer's disease research and treatments
Huazhong University of Science and Technology
2022
Abstract Abnormal tau accumulation and spatial memory loss constitute characteristic pathology symptoms of Alzheimer disease (AD). Yet, the intrinsic connections mechanism between them are not fully understood. In current study, we observed a prominent AD‐like hyperphosphorylated truncated (hTau N368) proteins in hippocampal dentate gyrus (DG) mossy cells 3xTg‐AD mice. Further investigation demonstrated that ventral DG (vDG) cell‐specific overexpressing hTau for 3 months induced cognitive...
10.1111/acel.13600
article
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Aging Cell
2022-03-31
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