Bone morphogenetic proteins (BMPs) are multifunctional structurally related to transforming growth factor-beta (TGF beta) and activin that can induce cartilage bone in vivo. Members of the TGF beta superfamily exert their biological effects via heteromeric serine/threonine kinase complexes type I II receptors. We previously obtained six different receptors, termed receptor-like kinase-1 (ALK-1) -6. ALK-5 is a receptor, ALK-2 ALK-4 ALK-3 ALK-6 receptors for osteogenic protein-1 (OP-1)/bone...

CD40 belongs to the tumor necrosis factor (TNF) receptor family. signaling involves recruitment of TNF receptor-associated factors (TRAFs) its cytoplasmic domain. We have identified a novel intracellular CD40-binding protein termed TRAF and (TTRAP) that also interacts with TNF-R75 CD30. The region domain is required for TTRAP association overlaps TRAF6 recognition motif. Association increases profoundly in response treatment cells CD40L. Interestingly, associates TRAFs, highest affinity...

Bone morphogenetic proteins (BMPs) are multifunctional structurally related to transforming growth factor-beta (TGF beta) and activin that can induce cartilage bone in vivo. Members of the TGF beta superfamily exert their biological effects via heteromeric serine/threonine kinase complexes type I II receptors. We previously obtained six different receptors, termed receptor-like kinase-1 (ALK-1) -6. ALK-5 is a receptor, ALK-2 ALK-4 ALK-3 ALK-6 receptors for osteogenic protein-1 (OP-1)/bone...

Medication adherence is essential for the control of symptoms and progression rheumatoid arthritis (RA) systemic lupus erythematosus (SLE). The aim study was to investigate medication in outpatients treatment RA SLE a university hospital Brazil. This quantitative, cross-sectional analytical study. A total 92 patients (55 37 patients) were included structured questionnaire patients' interview form collecting data from medical records used collection. Adherence drug assessed by Morisky scale...

Global agriculture loses over $100 billion of produce annually to crop pests such as insects. Many these either are not currently controlled by artificial means or have developed resistance against chemical pesticides. Long dsRNAs capable inducing RNAi in insects and emerging novel, highly selective alternatives for sustainable insect management strategies. However, there significant challenges associated with efficacy In this study, we synthesized a range chemically modified long an...

Este trabalho trata-se de estudo analítico, transversal, com abordagem quantitativa, que verificou a presença depressão e adesão ao tratamento quimioterápicos em pacientes oncológicos atendidos na Farmácia Central Quimioterapia um hospital universitário. A amostra constou 102 coleta dos dados foi realizada no período outubro 2010 maio 2011. Utilizou-se entrevista estruturada, norteada por roteiro contendo sociodemográficos, clínicos terapêuticos; o Teste Morisky Inventário Depressão Beck. Os...

This cross-sectional study was carried out with 1000 elderly outpatients assisted by a Basic Health District Unit (UBDS) from the Brazilian Public System (SUS) in municipality of Ribeirão Preto. We analyzed clinical, socioeconomic and pharmacoepidemiological profile patients order to identify factors associated polypharmacy amongst this population. used truncated negative binomial model examine association independent variables study. The software SAS for statistical analysis significance...

Autosomal dominant polycystic kidney disease (ADPKD) is a very common inherited caused by mutations in <i>PKD1 </i>or <i>PKD2</i> genes characterized progressive enlargement of fluid-filled cysts and loss renal function [<citeref rid="ref001">1</citeref>]. Previous studies proposed role for human polycystin-1 morphogenesis acting as matrix receptor focal adhesions polycystin-2 putative calcium channel rid="ref002">2</citeref>, <citeref...

A adesão ao tratamento medicamentoso nas doenças crônicas é um fator de importância clínica e social. Porém, são escassos os estudos deste tema em gastrintestinais crônicas. Assim, investigou-se a prescrito possíveis fatores que influenciam pacientes acompanhamento no ambulatório Gastroenterologia hospital universitário ligado Sistema Único Saúde (SUS) brasileiro. Um estudo transversal, com métodos indiretos para avaliar adesão, incluiu 110 pacientes, dos quais 72,6% tinham o medicamento...

RACIONAL: A adesão ao tratamento medicamentoso nas doenças inflamatórias intestinais apresenta grande importância clínica e social. Porém, são escassos os estudos sobre este tema em nosso meio. OBJETIVO: Investigou-se a prescrito, bem como influência de alguns fatores adesão, pacientes com acompanhamento ambulatório Gastroenterologia um hospital universitário ligado Sistema Único Saúde (SUS). MÉTODO: Realizou-se estudo transversal, métodos indiretos, para avaliar 26 casos da doença Crohn,...

The aim of Pharmaceutical Care programs is to improve patients' quality life, and such are particularly effective in the case chronic diseases as hypertension. objective this longitudinal study was analyze a model for hypertensive patients receiving care within Family Health Strategy (FHS). All were being seen by an FHS team affiliated primary healthcare unit Goiânia, Goiás, Brazil. Fourteen participated study, with each patient six home visits during Care. Overall, 142 drug-related problems...

ABSTRACT The objective was to describe and evaluate a model of drug dispensing developed implemented in community pharmacy Brazil. This descriptive, observational, quasi-experimental study performed the period between 21 January 2013 20 April 2013. evaluated described terms three parameters: structure, process outcome. description assessment each parameter as follows: (I) Structure: profile patients, pharmacist's professional profile, physical facility, informational material; (II) Process:...

Introduction: Pre-Exposure Prophylaxis (PrEP) for HIV involves the combined use of antiretrovirals individuals frequently exposed to HIV. Initially implemented in Brazil 2018 with a daily dosing regimen one pill, on-demand usage was recently (2022) incorporated into routine practice. Aim: To report experience providing pharmaceutical care an PrEP patient outpatient pharmacy within Brazil's Unified Health System. Outlining: This details that included reception patient, conducting anamnesis,...

An alternative form of nutrition therapy for patients with short bowel syndrome (SBS) who do not have home parenteral (PN) available is the administration PN cycle during regular hospital admissions and oral vitamin supplement at home. The aim this study was to evaluate serum levels folic acid vitamins A, B(12), C, E before after in SBS.This research conducted 10 SBS (less than 15 minutes total barium transit time) were receiving Patients evaluated regarding food ingestion intake. Serum...

SMAD proteins are downstream targets of serine/threonine kinase receptors the transforming growth factor β (TGFβ) superfamily. Ligands activating these regulate cell growth, differentiation and development in many tissues various organisms. In mammals eight different Smad genes known, each with roles mediating signalling between plasma membrane nucleus. Smad6 Smad7 inhibitors TGFβ family signalling. They both expressed human adult vascular endothelial cells, particularly after cells have...

ABSTRACT Global agriculture loses over $100 billion of produce annually to crop pests such as insects. Many these either have no current means control or developed resistance against chemical pesticides. Long dsRNAs are capable inducing RNA interference (RNAi) in insects and emerging novel highly selective alternatives for sustainable insect management strategies. However, there significant challenges associated with RNAi efficacy In this study, we synthesised a range chemically modified...

Although dispensing of medication has been addressed by theoretical models, studies that confirm the impact this service are still needed. The objective was to evaluate a new model medicine system on patients’ knowledge, adherence treatment and satisfaction. One hundred four patients attending community pharmacy between 21 January 2013 20 April were included in intervention study. satisfaction assessed using validated questionnaires at two time points: moment 30 days thereafter telephone...

Veterinary oncology is constituted mainly by human-use drugs with hazardous agents. Occupational risks are present in all stages of handling. Many studies highlighted that veterinarians and pharmacists staff a lack knowledge insufficient structure for promoting safety practices. This study investigated the professional profile veterinary antineoplastic chemotherapy Brazilian services.