A5054345347- Tendon Structure and Treatment
- Cyclopropane Reaction Mechanisms
- Osteoarthritis Treatment and Mechanisms
- Shoulder Injury and Treatment
- Knee injuries and reconstruction techniques
- NF-κB Signaling Pathways
- Organic Chemistry Cycloaddition Reactions
- Signaling Pathways in Disease
- Molecular Junctions and Nanostructures
- Bone Metabolism and Diseases
- Sports injuries and prevention
Peking University
2023-2024
Peking University Third Hospital
2023-2024
Beijing Sport University
2023
Meniscus is a complex and crucial fibrocartilaginous tissue within the knee joint. Meniscal regeneration remains to be scientific translational challenge. We clarified that mesenchymal stem cells (MSCs) participated in meniscal maturation using MSC-tracing transgenic mice model. Here, inspired by natural maturational regenerative process, we developed an effective strategy facilitate three-dimensionally printing biomimetic scaffold combining autologous synovium transplant, which contained...
Rotator cuff tear (RCT) is a prevalent shoulder injury that poses challenges for achieving continuous and functional regeneration of the tendon-to-bone interface (TBI). In this study, we controlled delivery growth factors (GFs) from liposomal nanohybrid cerasomes by ultrasound implanted three-dimensional printed polycaprolactone (PCL) scaffolds modified with polydopamine loaded bone marrow mesenchymal stem cells (BMSCs) to repair tears infraspinatus tendon in lapine model. Direct suturing...
Osteoarthritis (OA) is a debilitating joint disorder characterized by progressive cartilage degeneration. During OA, subchondral bone undergoes microstructural and molecular changes that precede degradation. However, specific mechanisms underlying metabolic dysregulation of the bone-cartilage unit remain unclear. This study aims to investigate role receptor-interacting protein kinase-3 (RIP3) in OA progression, focusing on homeostasis. RIP3-mediated pathological alterations chondrocytes,...