A5045226832- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Nerve injury and regeneration
- Neuroinflammation and Neurodegeneration Mechanisms
- Musculoskeletal pain and rehabilitation
- Anesthesia and Pain Management
- Inflammasome and immune disorders
- Bone Metabolism and Diseases
- Lung Cancer Research Studies
- Peptidase Inhibition and Analysis
- Cancer-related molecular mechanisms research
- Neurogenesis and neuroplasticity mechanisms
- Teleoperation and Haptic Systems
- Cervical and Thoracic Myelopathy
- Surgical Simulation and Training
- Multiple Sclerosis Research Studies
- Pelvic and Acetabular Injuries
- Osteoarthritis Treatment and Mechanisms
- Spinal Hematomas and Complications
- Molten salt chemistry and electrochemical processes
- Lymphatic System and Diseases
- Gout, Hyperuricemia, Uric Acid
- Axon Guidance and Neuronal Signaling
- NF-κB Signaling Pathways
- Mental Health Research Topics
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
Jilin University
2015-2024
First Hospital of Jilin University
2015-2024
Guiyang Medical University
2021-2024
Changjiang Water Resources Commission
2024
Ministry of Water Resources of the People's Republic of China
2024
Chinese Research Academy of Environmental Sciences
2023
Chengdu Medical College
2022-2023
First Affiliated Hospital of Chengdu Medical College
2023
Tencent (China)
2023
The formation of vascular niche is pivotal during the early stage peripheral nerve regeneration. Nevertheless, mechanisms in regulation repair remain unclear. Netrin-1 (NTN1) was found up-regulated stump after injury (PNI). Herein, we demonstrated that NTN1-high endothelial cells (NTN1+ECs) were critical component niche, fostering angiogenesis, axon regeneration, and repair-related phenotypes. We also NTN1+EC–derived exosomes (NTN1 EC-EXO) involved as a role. Multi-omics analysis further...
Breast cancer is the second most prevalent malignant tumor worldwide and highly heterogeneous. Cuproptosis, a newly identified form of cell death, intimately connected to lipid metabolism. This study investigated breast heterogeneity through lens cuproptosis-related metabolism genes (CLMGs), with goal predicting patient prognosis, immunotherapy efficacy, sensitivity anticancer drugs. By utilizing transcriptomic data from The Cancer Genome Atlas (TCGA) for cancer, we 682 CLMGs applied...
The present study aimed to identify novel intervertebral disc degeneration (IDD)‑associated long noncoding (lnc)RNAs and genes. lncRNA mRNA microarray dataset GSE56081 was downloaded from the Gene Expression Omnibus database included 5 samples patients with degenerative lumbar nucleus pulposus normal controls. Differentially expressed lncRNAs or differentially genes (DEGs) were identified co‑expression network analysis performed followed by functional for in network. Additionally, a microRNA...
Background Although PIWI-interacting RNAs (piRNAs) have recently been associated with germline development and many human diseases, their expression pattern relationship in autoimmune diseases remain indistinct. This study aimed to investigate the presence correlation of piRNAs rheumatoid arthritis (RA). Methods We first analyzed profile using small RNA sequencing peripheral leukocytes three new-onset untreated RA patients healthy controls (HCs). then selected related immunoregulation by...
Neuroanatomical tract tracers are important for studying axoplasmic transport and the complex interconnections of nervous system. Though traditional fluorescent widely used, they have several prominent drawbacks when imaging, including low resolutions tissue penetrations inability to be supervised dynamically within a long peripheral nerve during term. Here, we explored potential ICG as neural tracer first time demonstrated that could used detect function by near-infrared region II (NIR-II)...
The close spatial and temporal connection between osteogenesis angiogenesis around type H vasculature is referred as "osteogenesis-angiogenesis coupling", which one of the basic mechanisms osteogenesis. Endothelial cells (ECs), bone marrow mesenchymal stem (BMSCs), their specific lineage constitute important cluster that participate in regulation microenvironment. However, regulatory mechanism osteogenesis-angiogenesis coupling under condition healing has not been unveiled. In this study, we...
Abstract Background Quality of life (QoL) older adults has become a pivotal concern the public and health system. Previous studies found that both cognitive decline neuropsychiatric symptoms (NPS) can affect QoL in adults. However, it remains unclear how these are related to each other impact on QoL. Our aim is investigate complex network relationship between NPS adults, further explore their association with Methods A cross-sectional study was conducted sample 389 individuals complaints...
Background Postoperative discal pseudocyst (PDP) is a rare condition that presents after surgery for lumbar disc herniation. Due to the lack of information, diagnosis and treatment PDP remain controversial. Herein, we report case occurred following percutaneous endoscopic discectomy received conservative treatment. Additionally, review all published literature regarding propose our hypothesis pathology. Case summary A 23-year-old man presented with relapse low back pain numbness in his left...
Osteoarthritis (OA) is a debilitating joint disorder characterized by progressive cartilage degeneration. During OA, subchondral bone undergoes microstructural and molecular changes that precede degradation. However, specific mechanisms underlying metabolic dysregulation of the bone-cartilage unit remain unclear. This study aims to investigate role receptor-interacting protein kinase-3 (RIP3) in OA progression, focusing on homeostasis. RIP3-mediated pathological alterations chondrocytes,...
Abstract Rationale: Lumbar degeneration-related May-Thurner syndrome (dMTS) is characterized by venous compression induced degenerated lower lumbar structures. Treatment strategies for (MTS) include clearing the thrombus and correcting compression. Despite having different etiological factors from other MTS types, treatments dMTS are similar, including endovascular angioplasty continuous anticoagulation therapies. Thus, a particular treatment was designed herein to focus on compressive...
Microsurgery involves the dexterous manipulation of delicate tissue or fragile structures, such as small blood vessels and nerves, under a microscope.To address limitations imprecise human hands, robotic systems have been developed to assist surgeons in performing complex microsurgical tasks with greater precision safety.However, steep learning curve for robot-assisted microsurgery (RAMS) shortage well-trained pose significant challenges widespread adoption RAMS.Therefore, development...
Abstract Background Aspergillus fumigatus infection is difficult to diagnose clinically and can develop into invasive pulmonary aspergillosis, which has a high fatality rate. The incidence of increased die widespread application radiotherapy technology. However, knowledge regarding A. following radiation exposure limited, the underlying mechanism remains unclear. In this study, we established mouse model explore effect on associated mechanisms. Methods after was by irradiating with 5 Gy...
Abstract Rationale: Minimally invasive surgeries for thoracic disc herniation (TDH) evolved rapidly in recent years, and multiple approaches have been put forward. Thoracic discectomy via percutaneous spine endoscopy (PSE) is inadequately documented because of the low prevalence TDH high difficulty techniques. Herein, we present a case who underwent endoscopic discectomy. Patient concerns: A 28-year-old male suffered backpain partial paralysis lower extremities. Diagnoses: Magnet resonance...