Summary Background and objectives Prior studies have examined long-term outcomes of a single acute kidney injury (AKI) event in hospitalized patients. We the effects AKI episodes during multiple hospitalizations on risk chronic disease (CKD) cohort with diabetes mellitus (DM). Design, setting, participants, & measurements A total 4082 diabetics were followed from January 1999 until December 2008. The primary outcome was reaching stage 4 CKD (GFR <30 ml/min per 1.73 m 2 )....

: To examine the effect of severity acute kidney injury or renal recovery on risk-adjusted mortality across different intensive care unit settings. Acute in patients is associated with significant mortality.: Retrospective observational study.: There were 325,395 617,927 consecutive admissions to all 191 Veterans Affairs ICUs country.: Large national cohort admitted and who developed during their stay.: Outcome measures hospital mortality, length stay. was defined as a 0.3-mg/dL increase...

Bisphenol A (BPA) toxicity and exposure risk to humans has been the subject of considerable scientific debate; however, published occupational data for BPA are limited.In 2013-2014, 77 workers at six US companies making BPA, BPA-based resins, or BPA-filled wax provided seven urine samples over two consecutive work days (151 worker-days, 525 samples). Participant information included industry, job, tasks, personal protective equipment used, hygiene behaviors, canned food/beverage consumption....

Background and objectives AKI requiring dialysis is a contributor to the growing burden of kidney failure, yet little known about frequency patterns recovery its effect on outcomes in patients incident dialysis. Design, setting, participants, & measurements Using US Renal Data System, we evaluated cohort 1,045,540 from January 1, 2005 December 31, 2014, retrospectively. We examined association failure due with outcome all-cause mortality associations sex race recovery. Results Mean age...

Key Points Home hemodialysis is associated with decreased risk of stroke and acute coronary syndrome relative to peritoneal dialysis. cardiovascular death all-cause Background Cardiovascular disease the leading cause morbidity mortality in patients ESKD. Little known about differences outcomes between home (HHD) dialysis (PD). Methods We evaluated 68,645 who initiated January 1, 2005, December 31, 2018, using United States Renal Data System linked Medicare claims. Rates for incident events...

Significance Statement Pregnancy is not common in women on dialysis due to impaired fertility. Literature scarce about pregnancy the United States. In this retrospective study, authors examined rates and associated factors 47,555 US from 2005 2013. They identified 2352 pregnancies, for a rate of 17.8 per thousand person years, higher than seen previous studies. were highest Native American followed by Hispanics, blacks, Asians, whites. Younger age, hemodialysis as modality, ESKD caused GN,...

Cardiovascular disease is the leading cause of mortality in patients with kidney failure, and their risk cardiovascular events 10 to 20 times higher as compared general population.

Aim: This ambispective observational study assessed the impact of Noona, an electronic patient-reported outcomes (ePRO) platform, for patients with non-small cell lung cancer (NSCLC) treated in a community oncology setting. Methods: Adults advanced NSCLC, ECOG performance status 0–2, who received first-line (1L) pembrolizumab (monotherapy or chemotherapy) were eligible. Those initiating from 1 July 2017 to 30 June 2019, identified retrospectively (historical cohort), compared those October...

<b><i>Background:</i></b> Arteriovenous (AV) access confers survival benefits over central venous catheters (CVC) in hemodialysis patients. Although chronic kidney disease disproportionately affects women and racial minorities, disparities the ­utilization of across Asians, Native Americans, Hispanics, blacks, whites among males females after accounting for pre-dialysis health are not well studied. <b><i>Methods:</i></b> We evaluated 885,699...

<b><i>Background:</i></b> Acute kidney injury (AKI) during pregnancy is a public health problem and associated with maternal fetal morbidity mortality. Clinical outcomes care utilization in pregnancy-related AKI, especially women diabetes, are not well studied. <b><i>Methods:</i></b> Using data from the 2006 to 2015 Nationwide Inpatient Sample, we identified 42,190,790 hospitalizations aged 15–49 years. We determined factors including...

Exposure to bisphenol A (BPA) can be assessed using external and internal exposure measures. We examined the relationship between two measures of BPA (air hand-wipe samples) one (total in urine) for a group US manufacturing workers.During 2013-2014, we recruited 78 workers from six companies that made or products with BPA. quantified seven urine samples, full-shift air samples pre- end-shift collected over 2 consecutive days. correlations creatinine-corrected urinary concentrations total...

For decades, bisphenol A (BPA) has been used in making polycarbonate, epoxy, and phenolic resins certain investment casting waxes, yet published exposure data are lacking for U.S. manufacturing workers.In 2013–2014, BPA air hand exposures were quantified 78 workers at six companies or BPA-based products. Exposure measures included an inhalable-fraction personal sample on each of two consecutive work days (n = 146), pre- end-shift wipe samples the second day 74 each), surface 88). Potential...

Racial minorities and women constitute substantial portions of the incident prevalent end-stage renal disease (ESRD) population in United States. Although ESRD is characterized by high mortality, temporal trends, race sex differences mortality have not been studied.We evaluated 944,650 adult patients who initiated dialysis between January 1, 2005 December 31, 2014, using States Renal Data System, for sex-related race-related trends mortality. Logistic regression models adjusted pre-dialysis...

Background Flight attendants may have an increased risk of some cancers from occupational exposure to cosmic radiation and circadian disruption. Methods The incidence thyroid, ovarian, uterine cancer among ∼6000 female flight compared the US population was evaluated via life table analyses. Associations these cancers, melanoma, cervical with cumulative dose metrics disruption were using Cox regression. Results Incidence not elevated. No significant, positive exposure‐response relations...

Tris(1-chloro-2-propyl) phosphate (TCPP, also referenced as TCIPP), a flame retardant used in spray polyurethane foam insulation, increases cell toxicity and affects fetal development. Spray workers have the potential to be exposed TCPP during application. In this study, we determined exposure concentrations of urinary biomarker bis(1-chloro-2-propyl) (BCPP) among 29 over 2 work days. Work was conducted at residential or commercial facilities using both open-cell (low density) closed-cell...

Although end-stage kidney disease (ESKD) adversely affects fertility, pregnancies can occur among women receiving dialysis. ESKD increases the risk for adverse pregnancy outcomes and little is known about contraceptive use in undergoing dialysis.Retrospective cohort study.Using US Renal Data System covering January 1, 2005, through December 31, 2014, we evaluated each calendar year who entire were aged 15 to 44 years, dialysis, with Medicare as primary payer.Age, race/ethnicity, of prevalent...

Abstract Background Kidney transplant improves reproductive function in women with end-stage kidney disease. Little is known about contraceptive use history of transplants. Methods Using data from the United States Renal Data System, we evaluated for each calendar year transplantation between 1/1/2005 and 12/31/2013 who were aged 15–44 years Medicare as primary payer linked Network Organ Sharing, up to three entire after date transplantation. We determined rates used multivariable logistic...

This prospective study assessed the risk of developing rotator cuff syndrome (RCS) with separate or specific combinations biomechanical exposures measures, controlling for individual confounders.

BackgroundWomen with kidney failure have impaired fertility and are at a higher risk of maternal fetal morbidity mortality. Little is known about pregnancies in women receiving maintenance home dialysis the United States.MethodsUsing data from States Renal Data System, cohort 26,387 aged 15-49 years 2005-2018 was examined. We calculated pregnancy rates identified factors including modality associated dialysis.ResultsOverall, 437 were 26,837 on dialysis.Unadjusted rate 8.6 per 1000...

Acute kidney injury (AKI) is a major contributor to end-stage disease (ESKD). About one-third of patients with ESKD due AKI recover function. However, the inability accurately predict recovery leads improper triage clinical monitoring and impacts quality care in ESKD. Using data from United States Renal Data System 2005 2014 (n = 22 922), we developed score within 90 days 12 months after dialysis initiation AKI. Multivariable logistic regressions were used examine effect various covariates...

In a multicenter observational cohort of patients-admitted to intensive care units (ICU), we assessed whether creatinine elevation prior dialysis initiation in acute kidney injury (AKI-D) further discriminates risk-adjusted mortality. AKI-D was categorized into four groups (Grp) based on after ICU admission but before initiation: Grp I > 0.3 mg/dL <2-fold increase, II ≥2 times <3 III ≥3-fold increase creatinine, and IV none or <0.3 mg/dl increase. Standardized mortality rates (SMR) were...

Background Although kidney transplant improves reproductive function in women with end-stage disease (ESKD), pregnancy recipients' remains challenging due to the risk of adverse maternal and fetal outcomes. Methods We evaluated a retrospective cohort 7,966 who were aged 15–45 years received between January 1, 2005 December 31, 2011 from United States Renal Data System Medicare as primary payer for entire three after date transplantation. Unadjusted adjusted rates first post-transplant...

Background Patients with chronic kidney disease (CKD), a precursor of end stage renal (ESRD), face an increasing burden hospitalizations. Although mortality on dialysis is highest during the first year, impact pre-dialysis acute hospitalizations clinical outcomes in patients remains unknown. Methods We evaluated 170,897 adult who initiated between 1/1/2010 and 12/31/2014 linked Medicare claims from United States Renal Data System. Using logistic regression models, we examined association...

Reliance on administrative data sources and a cohort with restricted age range (Medicare 65 y above) may limit conclusions drawn from public reporting of 30-day mortality rates in 3 diagnoses [acute myocardial infarction (AMI), congestive heart failure (CHF), pneumonia (PNA)] Center for Medicaid Medicare Services.We categorized patients diagnostic codes AMI, CHF, PNA admitted to 138 Veterans Administration hospitals (2006-2009) into 2 groups (less than or ALL), then applied different models...