A5086715295- Neuroscience and Neuropharmacology Research
- S100 Proteins and Annexins
- Biochemical effects in animals
- Neurogenesis and neuroplasticity mechanisms
- Neurobiology and Insect Physiology Research
- Memory and Neural Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Neurological Disorders and Treatments
- Neuroendocrine regulation and behavior
- Human Health and Disease
- Chemical Reactions and Isotopes
- Neuropeptides and Animal Physiology
- Mitochondrial Function and Pathology
- Axon Guidance and Neuronal Signaling
- Receptor Mechanisms and Signaling
- Computational Drug Discovery Methods
- Pain Mechanisms and Treatments
- Stress Responses and Cortisol
- Nerve injury and regeneration
- Protein Hydrolysis and Bioactive Peptides
- Blood Pressure and Hypertension Studies
- Ion channel regulation and function
- Nuclear Receptors and Signaling
- Sodium Intake and Health
Institute of Normal Physiology named after P.K. Anokhin
2013-2023
Russian Academy of Sciences
2000-2017
Academy of Medical Sciences
2003-2015
Federal Agency for Scientific Organizations
2015
The effects of the novel proline-containing nootropic and neuroprotective dipeptide, noopept (GVS-111, N-phenylacetyl-L-prolylglycine ethyl ester) were investigated in NMRI mice following olfactory bulbectomy. We have shown previously that these animals developed Alzheimer's disease (AD)-like behaviour, morphology biochemistry including impairment spatial memory, regional neuronal degeneration elevated Aβ peptide brain levels. In current investigation, memory was assessed using Morris water...
Objective: Protein aggregation leading to central amyloid deposition is implicated in Parkinson’s disease (PD). During progression, inflammation and oxidative stress may well invoke humoral immunity against pathological aggregates of PD-associated α-synuclein. The aim was investigate any possible concurrence between autoimmune responses α-synuclein monomers, oligomers or fibrils with inflammation. Methods: formation species assessed by thioflavin-T assay atomic force microscopy employed...
Abstract Background Accumulated evidence suggests that insulin resistance and impairments in cerebral receptor signaling may contribute to age-related cognitive deficits Alzheimer's disease. The enhancement of is, therefore, a promising strategy for the treatment disorders. mitochondrial respiratory chain, being involved insulin-stimulated H 2 O production, has been identified recently as potential target signaling. aim present study is examine: (1) whether specific substrate, dicholine salt...
The novel human differentiating factor peptide fragment HLDF6 (Thr-Gly-Glu-Asn-His-Arg) was synthesized and purified. (0.1mg/kg i.p. but not 1mg/kg i.p.) improved only long-term (24h) memory in adult rats the water maze behavioural paradigm also performance delayed matching-to-position (DMTP) task (0.3 1.0 0.1mg/kg i.p). Hence, enhanced allocentric spatial learning reference (water maze) temporal, working processes DMTP paradigm. Immunoreactivity blotting analysis of HLDF (the protein...
NR2B-containing NMDA (NR2B/NMDA) receptors are important in controlling neurogenesis and involved generating spatial memory. Ro25-6981 is a selective antagonist at these actuates Inter-structural neuroanatomical profiles of gene expression regulating adult neuroapoptosis require examination the context memory retrieval reversal learning. The aim was to investigate learning relation expression-linked neurogenetic processes following blockade NR2B/NMDA by Ro25-6981. Rats were trained Morris...