A5075292756- Alzheimer's disease research and treatments
- S100 Proteins and Annexins
- Parkinson's Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Prion Diseases and Protein Misfolding
- Neurological diseases and metabolism
- Dementia and Cognitive Impairment Research
- Neurological Disease Mechanisms and Treatments
- Ocular Surface and Contact Lens
- Trace Elements in Health
- Botulinum Toxin and Related Neurological Disorders
- MicroRNA in disease regulation
- Nerve injury and regeneration
- Cell Adhesion Molecules Research
- Protease and Inhibitor Mechanisms
- Nuclear Receptors and Signaling
- Retinal Diseases and Treatments
- Corneal surgery and disorders
- Neuroscience and Neuropharmacology Research
- Ferroptosis and cancer prognosis
- Advanced Glycation End Products research
- Extracellular vesicles in disease
- Neuroscience and Neural Engineering
- Machine Learning in Bioinformatics
- Pluripotent Stem Cells Research
AbbVie (United States)
2017-2024
Hope Center for Neurological Disorders
2013-2017
Washington University in St. Louis
2013-2015
Umeå University
2006-2014
Recent experimental evidence suggests that transcellular propagation of fibrillar protein aggregates drives the progression neurodegenerative diseases in a prion-like manner. This phenomenon is now well described cell and animal models involves release into extracellular space. Free then enter neighboring cells to seed further fibrillization. The mechanism by which aggregated proteins such as tau α-synuclein bind trigger intracellular fibril formation unknown. Prior work indicates prion...
We previously found a strong reduction in tau pathology and insoluble P301S transgenic mice following intracerebroventricular infusion of the anti-tau antibody HJ8.5. sought to determine effects HJ8.5 same model peripheral administration.The primary objective was if administered at dose 50 mg kg(-1) week(-1) by intraperitoneal (IP) injection 6-month-old for 3 months would influence phospho-tau (p-tau) accumulation, insolubility, neurodegeneration.Treatment with mg/kg showed very decrease...
Auto-antibodies with specificity to self-antigens have been implicated in a wide variety of neurological diseases, including Parkinson's (PD) and Alzheimer's being sensitive indicators neurodegeneration focus for disease prevention. Of particular interest are the studies focused on auto-immune responses amyloidogenic proteins associated diseases their applications therapeutic treatments such as vaccination amyloid antigens antibodies PD, potentially other ailments.Generated auto-antibodies...
Pathological hallmarks of Alzheimer’s disease (AD) are deposits amyloid beta (Aβ) and hyper-phosphorylated tau aggregates in brain plaques. Recent studies have highlighted the importance Aβ tau-containing extracellular vesicles (EVs) AD. We therefore examined EVs separated from cerebrospinal fluid (CSF) AD, mild cognitive impairment (MCI), control (CTRL) patient samples to profile protein composition CSF EV. EV fractions were AD (n = 13), MCI 10), CTRL 10) using MagCapture Exosome Isolation...
Administration of an anti-tau antibody to transgenic mice expressing human tau and patients with tauopathy increased the concentration in plasma.
Background The conversion of soluble peptides and proteins into polymeric amyloid structures is a hallmark many age-related degenerative disorders, including Alzheimer's disease, type II diabetes variety systemic amyloidoses. We report here that formation linked to another major phenomenon − prostate tissue remodelling in middle-aged elderly men. Methodology/Principal Findings By using multidisciplinary analysis corpora amylacea inclusions glands patients diagnosed with cancer we have...
Peripheral immune responses can be sensitive indicators of disease pathology. We evaluated the autoimmune reactions to endocrine (insulin) and astrocytical (S100B) biomarkers in blood sera 26 Parkinson's (PD) patients compared with controls by using ELISA. found a statistically significant increase both antigens PD mean 70% 50% towards insulin S100B, respectively. Heterogeneity observed may reflect modulating effect multiple variables associated neurodegeneration also changes basic...
Abstract Human microglia are critically involved in Alzheimer’s disease (AD) progression, as shown by genetic and molecular studies. However, their role tau pathology progression human brain has not been well described. Here, we characterized 32 donors along of AD pathology, both time—from early to late pathology—and space—from entorhinal cortex (EC), inferior temporal gyrus (ITG), prefrontal (PFC) visual (V2 V1)—with biochemistry, immunohistochemistry, single nuclei-RNA-sequencing,...
Objective: Protein aggregation leading to central amyloid deposition is implicated in Parkinson’s disease (PD). During progression, inflammation and oxidative stress may well invoke humoral immunity against pathological aggregates of PD-associated α-synuclein. The aim was investigate any possible concurrence between autoimmune responses α-synuclein monomers, oligomers or fibrils with inflammation. Methods: formation species assessed by thioflavin-T assay atomic force microscopy employed...
Tau pathobiology has emerged as a key component underlying Alzheimer's disease (AD) progression; however, human neuronal in vitro models have struggled to recapitulate tau phenomena observed vivo. Here, we aimed define the minimal requirements achieve endogenous aggregation functional neurons utilizing induced pluripotent stem cell (hiPSC) technology. Optimized hiPSC-derived cortical seeded with AD brain-derived competent species or recombinant fibrils displayed increases insoluble,...
Abstract Background In Alzheimer’s disease (AD) progression, amyloid beta load uniformly increases across the brain cortex, while neurofibrillary tangles progressively spread in a stereotypical pattern from entorhinal to visual cortex. AD is known have strong genetic link microglia and recently, expression profiling at single cell resolution has identified disease‐associated populations with differential amyloid‐beta vs. tau pathology association human brain. However, prior studies focusing...